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Doctor insights on: Diabeta Second Generation Sulfonylurea

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Dr. Luis Curet
131 doctors shared insights

Glyburide (Definition)

Used with diet and exercise to help control blood sugar in patients with type 2 diabetes. It is an antidiabetic drug in a class of medications known as sulfonylureas, closely ...Read more


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Using amaryl (glimepiride) 3 before breakfast. Glocophage500+ glocovans 500?

Using amaryl (glimepiride) 3 before breakfast. Glocophage500+ glocovans 500?

Sulfonylurea.: That seems like a lot of sulfonylurea type medication - Glimepiride and Glyburide. The reason why that's important is that they can cause hypoglycemia (low blood sugar) which can be dangerous. I'd like to see you on more Metformin and less sulfonylurea to reduce your risk of hypoglycemia. ...Read more

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Type II diabetic, blood insulin last test (NOT glucose)=29.5 On lantus (insulin glargine) 62 units, humalog 17 units. Am I still producing endogenous insulin?

Type II diabetic, blood insulin last test (NOT glucose)=29.5 On lantus (insulin glargine) 62 units, humalog 17 units. Am I still producing endogenous insulin?

Need C-peptide test: Since exogenous (injected) insulin will show on a blood test, C-peptide should be measured to assess for endogenous insulin. Proinsulin is made by the pancreas, then cleaved into C-peptide & insulin. Exogenous insulin has no C-peptide. ...Read more

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Difference between first and second generation antihistamines? Why are 1st generation considered nonsedating?

Difference between first and second generation antihistamines? Why are 1st generation considered nonsedating?

Sedation: 1st generation are sedating because many people, up to 40%, get sleepy when taking them. 2nd generation antihistamines are chemically modified and are less likely to cause sedation. The generics of the less sedating are cetirizine, fexafenadine, and loratidine. They cause sedation in some people, up to 11%, but much less than the older drugs. ...Read more

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Are Glimepiride & glipizide the same drug?

Are Glimepiride & glipizide the same drug?

No, but same class: Both are 2nd generation sulfonylurea drugs for treatment of Type 2 Diabetes. According to a review by the Utah gov't, they conclude: "Overall ranges of HbA1c reduction seen w/glimepiride, glipizide & glyburide treatment in current literature are similar & choice of antidiabetes therapy should be based on individual patient characteristics, including: efficacy, cost, (see below) ...Read more

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Is the glipizide more effective than glyburide and januvia (sitagliptin)?

Is the glipizide more effective than glyburide and januvia (sitagliptin)?

No: Depending on how high your initial sugar levels are all 3 will lower the a1c about 0.3-1.0%. Glyburide is a poor choice for people with kidney problems and januvia (sitagliptin) is expensive. Most guidelines suggest beginning with metformin. Talk to your doctor. ...Read more

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Iam diabetic since 2003 and stoped ameryl in 2007 to start lantus (insulin glargine) insulin then novo mix 30 in 2009 with metforal 850 what new pills now more effective?

Iam diabetic since 2003 and stoped ameryl in 2007 to start lantus (insulin glargine) insulin then novo mix 30 in 2009 with metforal 850 what new pills now more effective?

There are a: variety of different medication regimens that can be effective, but you need to couple them to diet, exercise and weight loss. The most effective metformin dose is 1000 mg twice/day. Multiple doses of rapid acting Insulin before meals and a basal Insulin such as glargine at bedtime is better than mixed insulin. Other oral therapies and injectable glp-1 agonists need to be discussed with your docto ...Read more

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Diabetes insulin.Any alternative for the needles insulin?

Diabetes insulin.Any alternative for the needles insulin?

Insulin: If you have type 1 diabetes, you need insulin, which can be from injections or the pump that is placed inside you. Type 2 diabetes is from Insulin resistance and can be treated with oral medication and as that fails, you will need diabetes. The pump is an option, pancreatic transplants in certain candidates is another option. ...Read more

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Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good medicn?

Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good  medicn?

Not fertility meds: The medications you are describing are several antibiotics, vitamins and enzymes. None of these are infertility medications. If you are not sure why he/she prescribed them, you should ask your doctor what they are for. ...Read more

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What about actos (pioglitazone) as oral anti diabetic ?

What about actos (pioglitazone) as oral anti diabetic ?

I'm not a fan: Hi. The TZD era came and went for me. They're not bad drugs in most cases, but they can cause serious weight gain and fluid retention, and we have such better drugs now. I haven't prescribed pioglitazone in years. So, yes, it helps treat diabetes, but other drug choices may have better overall profiles. ...Read more

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Will i ever have a natural erection again? Taking androgen 4 pumps/d. Have dm ii, ex opioid addict, taking suboxone, Effexor 150mg/d, glucovance (glyburide and metformin)

Will i ever have a natural erection again?  Taking androgen 4 pumps/d.  Have dm ii,  ex opioid addict, taking suboxone, Effexor 150mg/d, glucovance (glyburide and metformin)

ED: Very difficult to say , it depends on how well your diabetes is controlled , how long you been on the androgen and it may or may not help. I hope you can to speak with your doctor at length about this. Good luck. ...Read more

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Took two, 3 hour glucose tolerance /insulin tests, one test had low blood sugar AND second test had high insulin both in the 3rd hour. How to treat?

Took  two, 3 hour glucose tolerance /insulin tests, one test had low blood sugar AND second test had high insulin both in the 3rd hour. How to treat?

Ignore it: and don't do the testing again. The GTT is NOT a valid test for hypoglycemia, and insulin levels are generally unreliable and meaningless. You are probably overweight with insulin resistance. Eat less, exercise more, and lose weight. ...Read more

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Insulin doses needed for type 2 diabetes > type 1?

Insulin doses needed for type 2 diabetes > type 1?

Insulin resistance: Patients with type 2 diabetes still make insulin, but they're resistant to it. Therefore, if someone with type 2 becomes Insulin dependent, very commonly the doses may be higher than those used in patients with type 1 diabetes. ...Read more

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Type2 DM women can have second child.probability of second child getting diabetes?

Type2 DM women can have second child.probability of second child getting diabetes?

Diabetes: If you have good control of your type 2 diabetes you should have no issues with a second child. To make sure this is the way it will be please do what you can to keep your blood sugar under control. PS: My mom had diabetes after she had 3 children and her youngest son, now age 65, has never had diabetes, Neither have I. ...Read more

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Blood insulin=29.5 On lantus (insulin glargine) 62 units, humalog 17 units. Am I still producing endogenous insulin?

Blood insulin=29.5 On lantus (insulin glargine) 62 units, humalog 17 units.  Am I still producing endogenous insulin?

Need more info: Most people diagnosed with type 2 diabetes continue to make insulin for many years. The way to tell this is by measuring a blood level of c-peptide. Also- Since you are only 45, if you are not obese, would check with your doctor to see if you might have later onset type 1. ...Read more

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Hi, diabetic, hypertens, on lantus (insulin glargine) and amaryl 2x3 glucophage5oox4, novonorm2x3 , A1c 9.7 cannot do more excercise due to arthralgia and oa chages ?

Hi, diabetic, hypertens, on lantus (insulin glargine) and amaryl 2x3 glucophage5oox4, novonorm2x3      , A1c 9.7    cannot do more excercise due to arthralgia and oa chages ?

WEIGHT LOSS CRUCIAL: WEIGHT LOSS IS CRUCIAL : I recommend a gluten free diet &WHOLEAPPROACH.COM/GUTBLISS.COM. If you have any sleep issues I would recommend as sleep study, there is a high overlap of sleep apnea and diabetes. Also I use Topamax (topiramate) in the evening for my diabetic patients it help with sleep/weight loss & improves insulin receptor sensitivity. ...Read more

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We think we just put novolog in the levemir (insulin detemir) bottle we have no more levemir (insulin detemir).... Is the levemir (insulin detemir) ruined it was 10 units..

We think we just put novolog in the levemir (insulin detemir) bottle we have no more levemir (insulin detemir).... Is the levemir (insulin detemir) ruined it was 10 units..

Novolog is rapid: Acting ; is used to cover sugars that are elevated pre meals, when you mix the two you could get reaction- do not use the mixture you now have. ...Read more

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Gave birth 6wks ago.am insulin resistant(high c peptide).got gestational diabetes @24 weeks.perfectly controled with diet.is it likely that its gone?

Gave birth 6wks ago.am insulin resistant(high c peptide).got gestational diabetes @24 weeks.perfectly controled with diet.is it likely that its gone?

Gestational diabetes: most gestational diabetes resolve postpartum. You need glucose challenge test 6 wks postpartum to determine if you now have real diabetes ...Read more

Dr. Saloni Khatri
29 doctors shared insights

Diabeta (Definition)

DiaBeta is a second generation sulfonylurea which is a kind of diabetes-related drug ...Read more