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Doctor insights on: Dhea Vs Cortisol

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What does testing cortisol and dhea tell us!?

What does testing cortisol and dhea tell us!?

Not much: These hormone levels naturally vary throughout the day, and are affected by stress, illness, medications. As is true for most hormones, the clinical setting, history, physical findings, are essential for determining if there is an abnormality or not. A random level is practically useless. ...Read more

Dhea (Definition)

Dhea= dihydroepiandrosterone ...Read more


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What would cause normal levels of cortisol but "undetectable" levels of DHEA?

What would cause normal levels of cortisol but "undetectable" levels of DHEA?

Steroidogenesis: Hi. Cortisol is a tightly regulated end product steroid hormone produced in the adrenals, whereas DHEA is an intermediate in the steroidogenic pathways in steroidogenic tissues (adrenal cortex, ovaries, testes), and not a regulated end product steroid. As long as you have enough cortisol, you're good. By your age (53), you're menopausal, and your ovarian DHEA is very low (~zero). ...Read more

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I have to do a 24 hour cortisol/dhea test but decided to suspend it because i had a poor night's sleep. Was i right to suspend the test?

I have to do a 24 hour cortisol/dhea test but decided to suspend it because i had a poor night's sleep. Was i right to suspend the test?

Yes: A poor night's sleep can disrupt the appropriate diurnal rhythms associated with cortisol production and give a "false positive" with regard to cortisol overproduction. ...Read more

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I am being tested for Cushings Disease. High DHEA-S, Hydroxyprogesterone and Cortisol levels, anything else I should be concerned about?

I am being tested for  Cushings Disease. High DHEA-S, Hydroxyprogesterone and Cortisol levels, anything else I should be concerned about?

Concerned: Yes you should be concerned but relax - your doctor will carefully go through the conditions you listed and probably see if you have additional issues. If you can, try and let the doctor know when you began to realize that something was a bit wrong. Please keep me posted. ...Read more

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Does DHEA-s have different levels throughout the day like testosterone or cortisol? How/where is it made in the body? When is it made?

Does DHEA-s have different levels throughout the day like testosterone or cortisol? How/where is it made in the body? When is it made?

Yes--highest in AM: DHEA is produced in the adrenals. It is the most abundant steroid hormone in the body. The levels are highest from 4-8 AM. DHEA levels are highest in the early 20s, and drop progressively thereafter. ...Read more

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What if the DHEA-S is high and you are not taking supplements? Mine has been flagged high twice in 7 months, so has my hydroxyprogesterone + cortisol

What if the DHEA-S is high and you are not taking supplements? Mine has been flagged high twice in 7 months, so has my hydroxyprogesterone + cortisol

See endocrinologist: nonspecific for high hormones, unsure why except unless you take supplements , should not go above normal lab values if so , see gland specialist [endocrinologist] ...Read more

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I have elevated morning cortisol, dhea-s and testosterone. My acth is normal. Is this common in women and are there any ways to fix it?

I have elevated morning cortisol, dhea-s and testosterone. My acth is normal. Is this common in women and are there any ways to fix it?

Hormone issue: Everyone's cortisol is higher in the AM, and almost all hormones have some kind of daily circadian rhythm. Whether or not you have a "disorder", or whether your hormones are normal, cannot be answered here. You need to see an endocrinologist. If menstrual irregularity is the main problem, a gyn endocrinologist may be a good choice. ...Read more

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Have low secretory IgA levels 79 mcg/ml, high dhea 0.61-0.91 ng/ml and total daily cortisol of 1.45 mcg/dl. I'm not taking any supplements. Feel tired?

Have low secretory IgA levels 79 mcg/ml, high dhea 0.61-0.91 ng/ml and total daily cortisol of 1.45 mcg/dl. I'm not taking any supplements. Feel tired?

Your IgA level is..: Your IgA level is normal. I high dhea level is usually associated with good health and longevity. Your fatigue has another cause! ...Read more

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My Testosterone, Thyriod, DHEA-s, 17- OHP, Cortisol, Prolactin & BP are normal level. But my Androstenedione is very high. What could this indicate?

Hard to tell: One would expect the T levels to be elevated as well. I am not sure what very high means. Sometimes in polycystic ovarian syndrome androstenedione is elevated. The fact that DHEAS, T are normal is reassuring. I would suggest talking with your ordering physician about this so that they can determine how significant this result really is. ...Read more

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39yr old female, why is testosterone 390ng/dl sohigh? Dhea-s low under 15ug/dl, period & cortisol normal. 2 years on 0.025 estrogen patch. No hairines

39yr old female, why is testosterone 390ng/dl sohigh? Dhea-s low under 15ug/dl, period & cortisol normal. 2 years on 0.025 estrogen patch. No hairines

Recheck promptly!: Testosterone 390 ng/dl (are you absolutely sure of units?) is extremely high for a female. Please have it checked again sooner not later; if still elevated you need prompt evaluation of the pelvis with imaging studies. With no hairiness (hirsutism) and regular periods I am suspicious the test is either in error or there's a confusion with units. ...Read more

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What does "feminizing" hormones mean? Male with high dhea, e1, e3 , progesterone and low cortisol. Testosterone lower limits

What does "feminizing" hormones mean?  Male with high dhea, e1, e3 , progesterone and low cortisol. Testosterone lower limits

Feminizing hormones: 38 M from PA asks" what does feminizing hormones mean". Have you ever heard of Google? Give this a try. In short they make a man into a woman-but mostly makes boobs get bigger and hurt and Increase risk of blood clots.. Need more information including picture and what you are taking. Happy to consult. ...Read more

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I have very high levels of DHEA (480) but borderline low cortisol (3.7). Endocrinologist says PCOS. I worry about adrenal fatigue. Should I worry?

Not normal: First of all there is no such thing as "adrenal fatigue" (not a real disease or condition). With high DHEA, you could have a steroidogenic enzyme deficiency causing congenital adrenal hyperplasia. Do you have any male-pattern hair growth? Irregular or absent periods? Other steroids & steroid intermediates I would check are: 17(OH)progesterone, Androstenedione, and testosterone; others to check too ...Read more

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Tiny adrenal tumor, h cortisol, h testosterone, h creatinine, h dheas, fast gluc 106. Hysterectomy, thyromegaly Will metformin reduce testosterone?

Tiny adrenal tumor, h cortisol, h testosterone, h creatinine, h dheas, fast gluc 106.   Hysterectomy, thyromegaly
Will metformin reduce testosterone?

Hormones: Metformin medicine that keeps your blood sugar under control should not have an effect on testosterone. That said, too much metformin will likely lower your testosterone. Are you checking your blood sugar regularly? Please let me know how things are going. ...Read more

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I have normal cortisol, progesterone, and estradiol but high testosterone and very high DHEAS (double normal range). I am also a type 1 diabetic and seem to be insulin resistant (hbA1C is 8.2). Could insulin resistance be the cause of elevated DHEAS?

I have normal cortisol, progesterone, and estradiol but high testosterone and very high DHEAS (double normal range). I am also a type 1 diabetic and seem to be insulin resistant (hbA1C is 8.2). Could insulin resistance be the cause of elevated DHEAS?

Yes...but: This day in age we are seeing some people with type 1 diabetes and features of insulin resistance, polycystic ovarian syndrome, metabolic syndrome and type 2 diabetes features. This sounds like PCOS, believed to usually be caused concern by insulin resistance. I am also concerned over a high prolactin, thyroid disease, or congenital adrenal hyperplasia and these should be completely checked too. ...Read more