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Doctor insights on: Deplin Medication

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Tell me about the drug deplin?

Tell me about the drug deplin?

Deplin: Deplin is l-methylfolate, which is the form of Folic Acid that crosses the blood-brain-barrier, where it is a cofactor in the formation of serotonin, norepinephrine and dopamine. There is literature to support that individuals with mood disorders are more likely to be deficient in the enzyme that methylates Folic Acid and so may be deficient in this vitamin. It is used to augment antidepressants. ...Read more

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How long before the positive affects of deplin are noticed? Typically that is.

3 to 6 weeks: Should give deplin at least 3 to 6 week trial, if you think you notice a difference at that point, stay on it longer. I'd say if nothing if any different whatsoever by 6 weeks, there is no reason to continue it. Best of luck! ...Read more

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How long do you usually take deplin? I am wanting to know b/c it's 66 bucks for generic.

A month or two: In theory low levels of folate (folic acid) could cause neurotransmitter deficiencies, which could be corrected by l-methylfolate (folic acid) supplementation. Deplin is a brand name for a that metabolite. Studies to date are not convincing it works and we don't know how to predict who should take it. After a month or two, i'd talk to your doc about something else. ...Read more

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What is the biggest difference in dose between 7.5 mg of deplin and 15mg. I feel better on 15 yet in someways feel very blah! What does this mean?

What is the biggest difference in dose between 7.5 mg of deplin and 15mg. I feel better on 15 yet in someways feel very blah! What does this mean?

Twice as much!: Deplin is a form of folic acid (one of the B vitamins). 15 mg has twice as much as 7.5 mg. Get your blood level of folic acid checked so you only take as much as you need: no more & no less. If is always better to get folic acid from foods, unless you have a problem absorbing it, or are pregnant or other diseases or on other meds where additional folate is important. Too much/ may affect mood. ...Read more

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Is there any risk to taking deplin supplement to homocystenene levels?

Is there any risk to taking deplin supplement to homocystenene levels?

No: Over the counter Folic Acid will work just as well. It would be good to consult your doctor to find out the cause and treat any effects of elevated homocystene levels. ...Read more

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Can you mix saphris (asenapine) and deplin?

Can you mix saphris (asenapine) and deplin?

Yes: No significant interactions were found when Deplin (l-methylfolate) & Saprhis (asenapine) are used together (using the Drugs. Com drug interaction checker.) ...Read more

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Should I take deplin supplement to lower homocystene levels?

Should I take deplin supplement to lower homocystene levels?

May help: Folic acid helps in reducing homocystene levels. Any over the counter preparation will do, you do not need to pay for proprietary preparation. It would be prudent to consult your doctor for an evaluation of your health and any other conditions that may be causing high homocystene levels for be causes by it. ...Read more

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Is deplin more likely to help gad and pa's or more likely to accentuate?

Is deplin more likely to help gad and pa's or more likely to accentuate?

No data available: I have looked into this and cannot find anything but anecdotal reports from people who said that it made their anxiety better or that it made their anxiety worse. I can't find any scientific literature on this. The approval is so far only for treatment of depression, with anxiety left out. I have given it to about 15 people and have not heard any complaints re: anxiety. Colleagues, chime in please. ...Read more

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Is it safe for an 18 year old male like me to take 15 mg of deplin every day?

Is it safe for an 18 year old male like me to take 15 mg of deplin every day?

Deplin: Agree w dr. Pappas ; dr. Cribari. It can be used by people with schizophrenia or major depression who have low folate (folic acid) levels. People w low folate (folic acid) related to Methotrexate use ; women with some high risk pregnancies (hyperhomocysteinemia). I have yet to use it and I do not know the optimum dosage. Please d/w your prescribing physician. ...Read more

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Understanding Deplin and Lexapro (escitalopram) somewhat compliment each other, Should they be taken together at the same time or spaced out?

Together: Psychiatry experts here at HealthTap have previously answered this question that it is safe to take Deplin (which contains methylfolate, an active form of folic acid/vitamin B6) at the same time as Lexapro (escitalopram). The bigger question is whether it is effective or adds benefit to the response to Lexapro (escitalopram). This seems to be variable and unpredictable. Good luck! ...Read more

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Does deplin work for ADHD in kids?

Does deplin work for ADHD in kids?

No studies yet: Deplin has not yet been studied in children with adhd, so we don't know the answer to this question. A clinical trial at nih is planned for adults with adhd, though. They plan to use deplin along with oros-methylphenidate -- but results will be some time in coming since they're only at the recruitment phase now. Sorry! ...Read more

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Can deplin upset your stomach?

Can deplin upset your stomach?

Deplin: Sure, for some with sensitive stomach. Recommend taking with food. ...Read more

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What is deplin? Would this work better than 5htp for anxiety and digestive issues?

What is deplin? Would this work better than 5htp for anxiety and digestive issues?

Not by itself: Deplin is l-methylfolate (folic acid) -- the active form of folate (folic acid) (methyltetrahydrofolate (folic acid), or mthf). This form can cross the blood-brain barrier, without having to be metabolized from the folate (folic acid) in your multivitamin or in food. It can be used to augment antidepressant effect, and in this way can help treatment-resistant depression. This can help depressed people who have mthf deficiencies. ...Read more

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Can a doc tell me the risks of me (18 year old male) taking 15 mg of deplin every day?

Can a doc tell me the risks of me (18 year old male) taking 15 mg of deplin every day?

Deplin: Deplin is l-methylfolate (folic acid) -- which bypasses possible mutations of genes coding for enzymes which naturally synthesize this active form of folate (folic acid). L-methylfolate (folic acid) is essential for many neurological functions. You haven't provided enough history to show whether you have this genetic mthfr mutation or need this supplement, but a holistic physician could help you. Http://www. Abihm. Org/. ...Read more

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Taking deplin with cymbalta (duloxetine) and on vicodin is this a bad mix?

Taking deplin with cymbalta (duloxetine) and on vicodin is this a bad mix?

If prescribed, okay: There are no interactions noted between Cymbalta (duloxetine) and vicodin. Deplin is l-methylfolate, a medical food meant to augment your antidepressant (cymbalta) by increasing folate to your nervous system. It is safe to use with these other meds also. ...Read more

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Is it possible deplin (l-methylfolate) to cause weight gain?

Is it possible deplin (l-methylfolate) to cause weight gain?

No: No. Are you taking other medication that helps with mood or sleep? other antidepressant medications can cause weight gain as can being depressed. Certainly talk about weight and appetite concerns with your prescribing doc. Try and eat high quality low quantity foods and get some exercise. Be well and good luck. ...Read more

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Are there any significant risks with taking deplin and developing colon cancer?

Are there any significant risks with taking deplin and developing colon cancer?

Complicated question: There are no specific studies of deplin and colon cancer. However, deficiencies of folate (folic acid) may be associated with an increased risk of colon cancer: http://tinyurl. Com/p28h8m6. On the other hand, if people have certain polymorphisms of mthfr, supplementation with Folic Acid (not necessarily deplin) may increase risk: http://tinyurl. Com/pdsulcn the company recommends caution w/existing tumors. ...Read more

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Are there any interactions by taking deplin, acetyl L-carnitine and lexapro (escitalopram)?

Are there any interactions by taking deplin, acetyl L-carnitine and lexapro (escitalopram)?

Drug interactions: Deplin and Lexapro (escitalopram) are safe. There are some reports of negative interactions on ehealthme. Com, and I would encourage you to type in Lexapro (escitalopram) and acetyl L-carnitine on that web site. This lists reported side effects among all the people who ever took the combo and bothered reporting, so statistical significance and scientific validity are lacking, but worth taking into consideration. Talk to your md. ...Read more

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What are the benefits (what is it used for?) of deplin? Doc put me on it. Low folate (folic acid) I am assuming?

L-methylfolate: Deplin is l-methylfolate (folic acid). Many chronically depressed people have small genetic mutations leading to inability to convert Folic Acid and folate (folic acid) to l-methylfolate (folic acid) -- the "active" form that crosses the blood-brain barrier to be used in making neurotransmitters. Deplin bypasses this problem, and can augment antidepressant response. Http://tinyurl. Com/lk938o3. ...Read more

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Is it possible to overdose on Deplin? If a doctor prescribes >40 or >60MG per day, ok? I know it's water soluble.

Is it possible to overdose on Deplin? If a doctor prescribes >40 or >60MG per day, ok? I know it's water soluble.

Great Question: Talk to your doctor about the appropriate dose of Deplin for you. I did find a study where the dose used in the study went up to 90mg per day. I am NOT recommending this for you or suggesting that you try this. Please discuss your treatment dose with your doctor. Sometimes a higher daily dose is needed to achieve therapeutic benefit. There is no dose adjustment needed for renal or liver disease. ...Read more

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I am 18 and take a multi vitamin, 5000 iu, and my therapist put me on deplin 15 mg, is deplin safe? He just recommended it to me and I have samples.

I am 18 and take a multi vitamin, 5000 iu, and my therapist put me on deplin 15 mg, is deplin safe? He just recommended it to me and I have samples.

Yes: Deplin or methylated folice acid is very safe. We use it in pregnant women to ensure normal development of the fetal nervous tissue. It is indicated for depression, dysthymia and neuropathy. ...Read more

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My gp is recom. Deplin to help with anxiety & digestive issues. I d/c remeron (mirtazapine) due bad side eff. & currently not on an ad. Is this better than 5htp?

My gp is recom. Deplin to help with anxiety & digestive issues. I d/c remeron (mirtazapine) due bad side eff. & currently not on an ad. Is this better than 5htp?

No: Deplin is Folic Acid which has been shown to help antidepressants work better. There are no data to support its use alone for depression. 5 htp is a serotonin precursor which may help with mild depression. ...Read more

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I am currently taking viibryd (vilazodone hydrochloride) 20mg daily and hydroxyzine 10mg prn for anxiety disorder. Symptoms are better but still anxious. MD added deplin. Good?

I am currently taking viibryd (vilazodone hydrochloride) 20mg daily and hydroxyzine 10mg prn for anxiety disorder. Symptoms are better but still anxious. MD added deplin. Good?

A study said "yes": There is evidence that methylfolate (Deplin) can help reduce symptoms of depression.

(Papakostas GI, et al. L-methylfolate as
adjunctive therapy for SSRI-resistant major depression: results of two
randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012 Dec
1;169 (12):1267-74.) ...Read more

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Deplin, acetyl l carnitine, magnesium and alpha lipoic acid. Interactions? Concerns?

Deplin, acetyl l carnitine, magnesium and alpha lipoic acid. Interactions? Concerns?

Your review is wise: There are no noted interactions between these substances and each other but each may have interactions with other substances. If you are on or plan to be on other substances or medications, advise doctor and pharmacist so interactions may be reviewed. Best regards for your health and well-being. ...Read more

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Understanding that deplin is the methyl folate (folic acid) needed to cross blood brain barrier, why is the dose so high 7.5 or 15mg? Non script mf is a lot lower

Understanding that deplin is the methyl folate (folic acid) needed to cross blood brain barrier, why is the dose so high 7.5 or 15mg? Non script mf is a lot lower

Biological activity: The l-methyl folate (folic acid) is the biologically active form and will directly affect receptors. You need to know that as we age, fully 52% of adults start to lose the ability to chemically convert folate (folic acid) properly. Therefore, over the counter folate (folic acid) is not identical, and the "methyl folate (folic acid)" sold in health food stores is often the reverse optical isomer and would be fully inactive. ...Read more

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