Doctor insights on:
Deplin: Deplin is l-methylfolate, which is the form of Folic Acid that crosses the blood-brain-barrier, where it is a cofactor in the formation of serotonin, norepinephrine and dopamine. There is literature to support that individuals with mood disorders are more likely to be deficient in the enzyme that methylates Folic Acid and so may be deficient in this vitamin. It is used to augment antidepressants. ...Read more
3 to 6 weeks: Should give deplin at least 3 to 6 week trial, if you think you notice a difference at that point, stay on it longer. I'd say if nothing if any different whatsoever by 6 weeks, there is no reason to continue it. Best of luck! ...Read more
A month or two: In theory low levels of folate (folic acid) could cause neurotransmitter deficiencies, which could be corrected by l-methylfolate (folic acid) supplementation. Deplin is a brand name for a that metabolite. Studies to date are not convincing it works and we don't know how to predict who should take it. After a month or two, i'd talk to your doc about something else. ...Read more
What is the biggest difference in dose between 7.5 mg of deplin and 15mg. I feel better on 15 yet in someways feel very blah! What does this mean?
Twice as much!: Deplin is a form of folic acid (one of the B vitamins). 15 mg has twice as much as 7.5 mg. Get your blood level of folic acid checked so you only take as much as you need: no more & no less. If is always better to get folic acid from foods, unless you have a problem absorbing it, or are pregnant or other diseases or on other meds where additional folate is important. Too much/ may affect mood. ...Read more
May help: Folic acid helps in reducing homocystene levels. Any over the counter preparation will do, you do not need to pay for proprietary preparation. It would be prudent to consult your doctor for an evaluation of your health and any other conditions that may be causing high homocystene levels for be causes by it. ...Read more
No data available: I have looked into this and cannot find anything but anecdotal reports from people who said that it made their anxiety better or that it made their anxiety worse. I can't find any scientific literature on this. The approval is so far only for treatment of depression, with anxiety left out. I have given it to about 15 people and have not heard any complaints re: anxiety. Colleagues, chime in please. ...Read more
Deplin: Agree w dr. Pappas ; dr. Cribari. It can be used by people with schizophrenia or major depression who have low folate (folic acid) levels. People w low folate (folic acid) related to Methotrexate use ; women with some high risk pregnancies (hyperhomocysteinemia). I have yet to use it and I do not know the optimum dosage. Please d/w your prescribing physician. ...Read more
Should deplin be taken at the same time as taking lexapro (escitalopram)? Or should the two meds be spaced out?
Both: Can be taken together.Get a more detailed answer ›
Understanding Deplin and Lexapro (escitalopram) somewhat compliment each other, Should they be taken together at the same time or spaced out?
Together: Psychiatry experts here at HealthTap have previously answered this question that it is safe to take Deplin (which contains methylfolate, an active form of folic acid/vitamin B6) at the same time as Lexapro (escitalopram). The bigger question is whether it is effective or adds benefit to the response to Lexapro (escitalopram). This seems to be variable and unpredictable. Good luck! ...Read more
Does Deplin ehance ssri's. If so should you take a lower does of the ssri if you are starting one? Would Deplin increase the side effects of the ssri
No studies yet: Deplin has not yet been studied in children with adhd, so we don't know the answer to this question. A clinical trial at nih is planned for adults with adhd, though. They plan to use deplin along with oros-methylphenidate -- but results will be some time in coming since they're only at the recruitment phase now. Sorry! ...Read more
Not by itself: Deplin is l-methylfolate (folic acid) -- the active form of folate (folic acid) (methyltetrahydrofolate (folic acid), or mthf). This form can cross the blood-brain barrier, without having to be metabolized from the folate (folic acid) in your multivitamin or in food. It can be used to augment antidepressant effect, and in this way can help treatment-resistant depression. This can help depressed people who have mthf deficiencies. ...Read more
Deplin: Deplin is l-methylfolate (folic acid) -- which bypasses possible mutations of genes coding for enzymes which naturally synthesize this active form of folate (folic acid). L-methylfolate (folic acid) is essential for many neurological functions. You haven't provided enough history to show whether you have this genetic mthfr mutation or need this supplement, but a holistic physician could help you. Http://www. Abihm. Org/. ...Read more
No: No. Are you taking other medication that helps with mood or sleep? other antidepressant medications can cause weight gain as can being depressed. Certainly talk about weight and appetite concerns with your prescribing doc. Try and eat high quality low quantity foods and get some exercise. Be well and good luck. ...Read more
Complicated question: There are no specific studies of deplin and colon cancer. However, deficiencies of folate (folic acid) may be associated with an increased risk of colon cancer: http://tinyurl. Com/p28h8m6. On the other hand, if people have certain polymorphisms of mthfr, supplementation with Folic Acid (not necessarily deplin) may increase risk: http://tinyurl. Com/pdsulcn the company recommends caution w/existing tumors. ...Read more
Drug interactions: Deplin and Lexapro (escitalopram) are safe. There are some reports of negative interactions on ehealthme. Com, and I would encourage you to type in Lexapro (escitalopram) and acetyl L-carnitine on that web site. This lists reported side effects among all the people who ever took the combo and bothered reporting, so statistical significance and scientific validity are lacking, but worth taking into consideration. Talk to your md. ...Read more
What are the benefits (what is it used for?) of deplin? Doc put me on it. Low folate (folic acid) I am assuming?
L-methylfolate: Deplin is l-methylfolate (folic acid). Many chronically depressed people have small genetic mutations leading to inability to convert Folic Acid and folate (folic acid) to l-methylfolate (folic acid) -- the "active" form that crosses the blood-brain barrier to be used in making neurotransmitters. Deplin bypasses this problem, and can augment antidepressant response. Http://tinyurl. Com/lk938o3. ...Read more
Is it possible to overdose on Deplin? If a doctor prescribes >40 or >60MG per day, ok? I know it's water soluble.
Great Question: Talk to your doctor about the appropriate dose of Deplin for you. I did find a study where the dose used in the study went up to 90mg per day. I am NOT recommending this for you or suggesting that you try this. Please discuss your treatment dose with your doctor. Sometimes a higher daily dose is needed to achieve therapeutic benefit. There is no dose adjustment needed for renal or liver disease. ...Read more
I am 18 and take a multi vitamin, 5000 iu, and my therapist put me on deplin 15 mg, is deplin safe? He just recommended it to me and I have samples.
My gp is recom. Deplin to help with anxiety & digestive issues. I d/c remeron (mirtazapine) due bad side eff. & currently not on an ad. Is this better than 5htp?
I am currently taking viibryd (vilazodone hydrochloride) 20mg daily and hydroxyzine 10mg prn for anxiety disorder. Symptoms are better but still anxious. MD added deplin. Good?
A study said "yes":
There is evidence that methylfolate (Deplin) can help reduce symptoms of depression.
(Papakostas GI, et al. L-methylfolate as
adjunctive therapy for SSRI-resistant major depression: results of two
randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012 Dec
1;169 (12):1267-74.) ...Read more
Your review is wise: There are no noted interactions between these substances and each other but each may have interactions with other substances. If you are on or plan to be on other substances or medications, advise doctor and pharmacist so interactions may be reviewed. Best regards for your health and well-being. ...Read more
I'm a 18 y/o male and I take deplin, multi-vitamin, and vitamin d3. I was just prescribed Norvasc (amlodipine) 5 mg for high bp. Any bad interactions with those?
None: You may safely take them together.Get a more detailed answer ›
Understanding that deplin is the methyl folate (folic acid) needed to cross blood brain barrier, why is the dose so high 7.5 or 15mg? Non script mf is a lot lower
Biological activity: The l-methyl folate (folic acid) is the biologically active form and will directly affect receptors. You need to know that as we age, fully 52% of adults start to lose the ability to chemically convert folate (folic acid) properly. Therefore, over the counter folate (folic acid) is not identical, and the "methyl folate (folic acid)" sold in health food stores is often the reverse optical isomer and would be fully inactive. ...Read more