Doctor insights on:
Deplin: Deplin is l-methylfolate, which is the form of Folic Acid that crosses the blood-brain-barrier, where it is a cofactor in the formation of serotonin, norepinephrine and dopamine. There is literature to support that individuals with mood disorders are more likely to be deficient in the enzyme that methylates Folic Acid and so may be deficient in this vitamin. It is used to augment antidepressants. ...Read moreSee 1 more doctor answer
3 to 6 weeks: Should give deplin at least 3 to 6 week trial, if you think you notice a difference at that point, stay on it longer. I'd say if nothing if any different whatsoever by 6 weeks, there is no reason to continue it. Best of luck! ...Read more
A month or two: In theory low levels of folate (folic acid) could cause neurotransmitter deficiencies, which could be corrected by l-methylfolate (folic acid) supplementation. Deplin is a brand name for a that metabolite. Studies to date are not convincing it works and we don't know how to predict who should take it. After a month or two, i'd talk to your doc about something else. ...Read more
What is the biggest difference in dose between 7.5 mg of deplin and 15mg. I feel better on 15 yet in someways feel very blah! what does this mean?
Twice as much!: Deplin is a form of folic acid (one of the B vitamins). 15 mg has twice as much as 7.5 mg. Get your blood level of folic acid checked so you only take as much as you need: no more & no less. If is always better to get folic acid from foods, unless you have a problem absorbing it, or are pregnant or other diseases or on other meds where additional folate is important. Too much/ may affect mood. ...Read moreSee 1 more doctor answer
May help: Folic acid helps in reducing homocystene levels. Any over the counter preparation will do, you do not need to pay for proprietary preparation. It would be prudent to consult your doctor for an evaluation of your health and any other conditions that may be causing high homocystene levels for be causes by it. ...Read more
No data available : I have looked into this and cannot find anything but anecdotal reports from people who said that it made their anxiety better or that it made their anxiety worse. I can't find any scientific literature on this. The approval is so far only for treatment of depression, with anxiety left out. I have given it to about 15 people and have not heard any complaints re: anxiety. Colleagues, chime in please. ...Read more
Deplin: Agree w dr. Pappas ; dr. Cribari. It can be used by people with schizophrenia or major depression who have low folate (folic acid) levels. People w low folate (folic acid) related to Methotrexate use ; women with some high risk pregnancies (hyperhomocysteinemia). I have yet to use it and I do not know the optimum dosage. Please d/w your prescribing physician. ...Read moreSee 3 more doctor answers
Should deplin be taken at the same time as taking lexapro (escitalopram)? Or should the two meds be spaced out?
Both: Can be taken together.Get a more detailed answer ›
Understanding Deplin and Lexapro (escitalopram) somewhat compliment each other, Should they be taken together at the same time or spaced out?
Together: Psychiatry experts here at HealthTap have previously answered this question that it is safe to take Deplin (which contains methylfolate, an active form of folic acid/vitamin B6) at the same time as Lexapro (escitalopram). The bigger question is whether it is effective or adds benefit to the response to Lexapro (escitalopram). This seems to be variable and unpredictable. Good luck! ...Read more
Does Deplin ehance ssri's. If so should you take a lower does of the ssri if you are starting one? Would Deplin increase the side effects of the ssri
No studies yet: Deplin has not yet been studied in children with adhd, so we don't know the answer to this question. A clinical trial at nih is planned for adults with adhd, though. They plan to use deplin along with oros-methylphenidate -- but results will be some time in coming since they're only at the recruitment phase now. Sorry! ...Read moreSee 1 more doctor answer
Not by itself: Deplin is l-methylfolate (folic acid) -- the active form of folate (folic acid) (methyltetrahydrofolate (folic acid), or mthf). This form can cross the blood-brain barrier, without having to be metabolized from the folate (folic acid) in your multivitamin or in food. It can be used to augment antidepressant effect, and in this way can help treatment-resistant depression. This can help depressed people who have mthf deficiencies. ...Read more
Deplin: Deplin is l-methylfolate (folic acid) -- which bypasses possible mutations of genes coding for enzymes which naturally synthesize this active form of folate (folic acid). L-methylfolate (folic acid) is essential for many neurological functions. You haven't provided enough history to show whether you have this genetic mthfr mutation or need this supplement, but a holistic physician could help you. http://www.abihm.org/. ...Read moreSee 1 more doctor answer
No: no. are you taking other medication that helps with mood or sleep? other antidepressant medications can cause weight gain as can being depressed. certainly talk about weight and appetite concerns with your prescribing doc. try and eat high quality low quantity foods and get some exercise. be well and good luck. ...Read more
Complicated question: There are no specific studies of deplin and colon cancer. However, deficiencies of folate (folic acid) may be associated with an increased risk of colon cancer: http://tinyurl.Com/p28h8m6 . On the other hand, if people have certain polymorphisms of mthfr, supplementation with Folic Acid (not necessarily deplin) may increase risk: http://tinyurl.Com/pdsulcn the company recommends caution w/existing tumors. ...Read more