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Doctor insights on: Depakote Withdrawal

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Since Depakote and benzodiazepines affect gaba, would someone discontinuing Depakote experience symptoms similar to benzo withdrawal. If not, why not?

Since Depakote and benzodiazepines affect gaba, would someone discontinuing Depakote experience symptoms similar to benzo withdrawal. If not, why not?

A little different: It depends on the variables you are examining. From the standpoint of seizure prevention, stopping either medicine suddenly can result in in a seizure threshold that is lower than before the medicine was initiated. However, the half life of Depakote is much longer than most benzodiazepines so the effects of stopping it are more subtle than sudden discontinuation of benzodiazepines. Stay safe! ...Read more

Dr. Jeffrey Cohen
237 doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, ..Etc.It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more


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After 20+ yrs (simple-partial) seizure free, going off Depakote (250mg, 4x/day), drop. 250 every 2 wks. At 500 mg, feeling anxious.Withdrawal symptom?

After 20+ yrs (simple-partial) seizure free, going off Depakote (250mg, 4x/day), drop. 250 every 2 wks. At 500 mg, feeling anxious.Withdrawal symptom?

Depakote taper: Depakote is used in psychiatry for anxiety and anxious depression. In patients seizure free who I have tapered slowly off depakote, many have experienced the symptoms you are describing, but you should check with the practitioner monitoring your taper. ...Read more

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Seizure-free for 20 yrs; discontinued 1000 mg Depakote over 2 months. No seizures, but new anxiety. Lower gaba? Withdrawal syndrome? How long? Treat?

Medication: If Depakote has helped you for seizures for 20 years, it can also help with mood changes and anxiety. If something has been working that long without side effects not advisable to stop it. ...Read more

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How long do the withdrawal symptoms from depacote last?

How long do the withdrawal symptoms from depacote last?

Depak ore: Typically there is not a withdrawal syndrome associated with the discontinuation of depakote. As the medication is used to treat such conditions as bipolar disorder, seizures, and headaches, and these conditions may recur or intensify with abrupt stopping of the drug, it is recommended to gradually lower the dose and stop in consultation with the prescribing physician. ...Read more

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Is Depakote stored in fat?

Is Depakote stored in fat?

No: Depakote is metabolized almost exclusively by the liver via glucuronide conjugation and mitochondrial beta oxidation. It is excreted in the urine. Further information: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ded64147-7a43-4055-accc-2c011828079d ...Read more

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Please describe the medication: depakote?

Seizure medication: Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, weight gain and tremors. ...Read more

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Is Depakote a mood stabalizer?

Is Depakote a mood stabalizer?

Can be...: Depakote is in the class of anticonvulsants medications however in psychiatry it is also considered a mood stabilizer. Uses include the treatment mania, epilepsy, and migraine prophylaxis, . ...Read more

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Does Depakote have any street value?

Does Depakote have any street value?

No: It does not cause a high and has some pretty serious potential side effects if not carefully monitored. It also does not enhance thinking. Depakote has been studied as a treatment for behavioral problems in dementia and autism (among other disorders) but was not found to have benefits for either disorder. Therefore i cannot see how it could be used as a street drug. ...Read more

Depakote (Definition)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more