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Doctor insights on: Depakote Withdrawal

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Since Depakote and benzodiazepines affect gaba, would someone discontinuing Depakote experience symptoms similar to benzo withdrawal. If not, why not?

Since Depakote and benzodiazepines affect gaba, would someone discontinuing Depakote experience symptoms similar to benzo withdrawal. If not, why not?

A little different: It depends on the variables you are examining. From the standpoint of seizure prevention, stopping either medicine suddenly can result in in a seizure threshold that is lower than before the medicine was initiated. However, the half life of Depakote is much longer than most benzodiazepines so the effects of stopping it are more subtle than sudden discontinuation of benzodiazepines. Stay safe! ...Read more

Dr. Jeffrey Cohen
243 doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, ..Etc.It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more


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After 20+ yrs (simple-partial) seizure free, going off Depakote (250mg, 4x/day), drop. 250 every 2 wks. At 500 mg, feeling anxious.Withdrawal symptom?

After 20+ yrs (simple-partial) seizure free, going off Depakote (250mg, 4x/day), drop. 250 every 2 wks. At 500 mg, feeling anxious.Withdrawal symptom?

Depakote taper: Depakote is used in psychiatry for anxiety and anxious depression. In patients seizure free who I have tapered slowly off depakote, many have experienced the symptoms you are describing, but you should check with the practitioner monitoring your taper. ...Read more

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Seizure-free for 20 yrs; discontinued 1000 mg Depakote over 2 months. No seizures, but new anxiety. Lower gaba? Withdrawal syndrome? How long? Treat?

Medication: If Depakote has helped you for seizures for 20 years, it can also help with mood changes and anxiety. If something has been working that long without side effects not advisable to stop it. ...Read more

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How long do the withdrawal symptoms from depacote last?

How long do the withdrawal symptoms from depacote last?

Depak ore: Typically there is not a withdrawal syndrome associated with the discontinuation of depakote. As the medication is used to treat such conditions as bipolar disorder, seizures, and headaches, and these conditions may recur or intensify with abrupt stopping of the drug, it is recommended to gradually lower the dose and stop in consultation with the prescribing physician. ...Read more

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Is Depakote stored in fat?

Is Depakote stored in fat?

No: Depakote is metabolized almost exclusively by the liver via glucuronide conjugation and mitochondrial beta oxidation. It is excreted in the urine. Further information: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ded64147-7a43-4055-accc-2c011828079d ...Read more

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Please describe the medication: depakote?

Seizure medication: Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, weight gain and tremors. ...Read more

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Is Depakote a mood stabalizer?

Is Depakote a mood stabalizer?

Can be...: Depakote is in the class of anticonvulsants medications however in psychiatry it is also considered a mood stabilizer. Uses include the treatment mania, epilepsy, and migraine prophylaxis, . ...Read more

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Does Depakote have any street value?

Does Depakote have any street value?

No: It does not cause a high and has some pretty serious potential side effects if not carefully monitored. It also does not enhance thinking. Depakote has been studied as a treatment for behavioral problems in dementia and autism (among other disorders) but was not found to have benefits for either disorder. Therefore i cannot see how it could be used as a street drug. ...Read more

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Can you take cholest-off with depakote?

Can you take cholest-off with depakote?

Yes, no problem: Cholest-off is an otc prep that really does reduce cholesterol levels by blocking fat absorption, but will not affect Depakote levels or effects on your condition. If you have any doubt, easy to check your Depakote blood level. ...Read more

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What causes Depakote blood to fluctuate?

What causes Depakote blood to fluctuate?

Depends: Depakote levels can vary based on when your last dose was in relation to your blood being drawn for your test. They vary by person. Other medications can affect the metabolism of Depakote and intern cause the levels to fluctuate. Various medical conditions also can affect the levels. ...Read more

Dr. Alan Ali Dr. Ali
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What would a Depakote overdose feel like?

Dr. Alan Ali Dr. Ali
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What would a Depakote overdose feel like?

Depakote: Depending on dose taken, dizziness, upset stomach, tremors, headaches, etc. ...Read more

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What are the tests for Depakote overdose?

What are the tests for Depakote overdose?

Exam & blood test: Sedation plus history suggestive of overdose are usual first signs, confirmed by blood test. Any significant concerns of overdose should be considered an emergency with immediate contact with your doctor or trip to an emergency room. ...Read more

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Side effects of depakote, do they go away?

Side effects of depakote, do they go away?

Sometimes: Some side effects go away, or at least get better, over time, and some do not. It sounds like you really need to discuss the situation in more detail with the person prescribing the depakote. ...Read more

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Does Depakote slow down your metaboliam a lot?

Does Depakote slow down your metaboliam a lot?

No: Depakote frequently causes sleepiness and appetite increase. The combination of the two often results in weight gain and a feeling of having little energy. This is the medication, not a change in metabolism. ...Read more

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Why would Depakote be prescribed for a patient?

Why would Depakote be prescribed for a patient?

Mood, pain, seizure: Depakte is an anticonvulsant medication so can be used for seizures. However many newer drugs seem better for seizures with fewer side effects. Now departed is mainly used as a mood stabilizer for people with bipolar disorder, or or several types of chronic pain syndromes. ...Read more

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What effects does Depakote have on the human body?

Depakote: Some of the more serious effects include a severe skin reaction, weakness, easy bruising, lethargy, and confusion. Others include hair loss, vision changes, changes in menstruation, and GI upset. ...Read more

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Can I tak depakote 250 and fioricet 300-50-40 together?

Can I tak depakote 250 and fioricet 300-50-40 together?

There is interaction: According to FDA there is drug interaction and it depends on how long you are going to take them together.Discuss with your Doctor or pharmacist before you take them together ...Read more

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What is the definition or description of: Depakote overdose?

What is the definition or description of: Depakote overdose?

OD=toxic blood level: Manifestations of depakote OD are: Hyperthermia/hypothermia, Tachycardia, Hypotension (with severe overdose), Cardiac arrest (with severe overdose), Respiratory depression necessitating intubation. Typical dosing of depakote are 500mg 2-3 times per day for seizures and bipolar disorder. However, the blood level is what really matters. The therapeutic l range= 50-125ug/ml; toxic range=>150ug/ml. ...Read more

Depakote (Definition)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more