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Doctor insights on: Depakote Vs Lithium Bipolar

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How often is lithium used today, to treat bipolar 1? Is it more effective in stabilization than depakote or others that are similar?

How often is lithium used today, to treat bipolar 1? Is it more effective in stabilization than depakote or others that are similar?

Quite often : Lithium is one of the most effective mood stabilizers working for both sides of BD, decreasing SI. It is also has several serious side effects to consider.Please discuss the SE and BENEFITS with your doc. ...Read more

Dr. Jeffrey Cohen
244 doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, ..Etc.It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more


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Can a mood stabilizer like Depakote or lithium for bipolar disorder works only for the manic episodes?

Can a mood stabilizer like Depakote or lithium for bipolar disorder works only for the manic episodes?

Yes: In fact, we have far better treatments for mania than we do the depressed side of this illness. We are all hoping that better treatments for bipolar depression will be found. ...Read more

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Can you tell me about Depakote for bipolar?

Can you tell me about Depakote for bipolar?

Depakote is used: As mood stabilizer ; is often effective in the treatment of bipolar disorder. This article has good information: http://www.Drugs.Com/depakote.Html. ...Read more

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How does Depakote make bipolar people more stable?

Mood stabilzer: Depakote, is the enteric coated form of valproic acid. Depakote works thru a neurotransmitter in the brain called: gaba. Gaba is an inhibitory neurotransmitter. The precise mechanism of action for treatment of bipolar disorder is unknown. Depakote is also used for the treatment of seizures as well as migraine headaches. While very effective, Depakote does have side effects such as weight gain. ...Read more

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Is Depakote used for bipolar depression as well as mania?

Is Depakote used for bipolar depression as well as mania?

No: Depakote is formally approved for mania and mixed episodes (or irritable mania) in Bipolar Disorder. It is also commonly used as a maintenance medication (i.e. a true mood stabilizer) to decrease the total number of mood episodes in a year. However, it has not been shown to help depressions in Bipolar Disorder ...Read more

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I take Depakote for bipolar- i think i start feeling edgy or as if its getting close to needing my next dose. Is it normal & doe's it wear off?

I take Depakote for bipolar- i think i start feeling edgy or as if its getting close to needing my next  dose.  Is it normal & doe's it wear off?

DR or ER: There are 2 different forms of depakote. Dr has a shorter half life and is usually dosed twice a day. Er has a longer half life and is usually dosed once a day. Perhaps you are a rapid metabolized and need more frequent doses or perhaps you are not on a therapeutic dose. Have you had a blood level recently. Please discuss this with your psychiatrist. ...Read more

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Could Depakote (bipolar medication) increase the potency of vyvance?

Drug drug interactio: There are no known drug drug interactions between Depakote and vyvance. ...Read more

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Is valproate acid (depakote) effective for treating bipolar mixed depressive states?

Is valproate acid (depakote) effective for treating bipolar mixed depressive states?

Yes. : Bipolar disorders are complex to understand and to treat. Combining proper medication with therapy is ideal ...Read more

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Is Depakote a safe medicine? Im on a lot of meds,my ALT & Creatine R sometimes elevated. My Psych MD@Emory wants me try it bc I hav severe Bipolar D/O

Is Depakote a safe medicine? Im on a lot of meds,my ALT & Creatine R sometimes elevated. My Psych MD@Emory wants me try it bc I hav severe Bipolar D/O

Depends.: Your psychiatrist is the best person to determine what medications to use given your physical condition and what is safe to use. All medications have side-effects and I believe your psychiatrist is on top of monitoring your ability to tolerate them by taking lab tests. I can tell you from experience that this medication has been effective in Bipolar Disorder. ...Read more

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I have bipolar disorder i take medications zyprexa, (olanzapine) lamictal and Depakote 500 e.R and i smoked hash weed with medications sometimes i need an advice?

I have bipolar disorder i take medications zyprexa, (olanzapine) lamictal and Depakote 500 e.R and i smoked hash weed with medications sometimes i need an advice?

Bipolar Treatment: The research clearly shows that people suffering from bipolar disorder have the best outcomes with a combination of medication and psychotherapy. Psychotherapy should occur for an hour at least 1 or 2 times a month and sometimes more often during the course of treatment. Such treatment by good doctors can result in excellent outcomes. Smoking weed or hash is not associated with good outcomes. ...Read more

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I take Depakote for my bipolar 2 disorder will taking a mix of creatine and arginine have any side effects?

Why: Not sure why you would be taking arginine and creatine. Frolic acid and omega 3 supplementation are helpful. Any combination of medications prescribed or otc should be used with caution. Make sure you tell your doctor about all therapeutic substances you are taking so they can help monitor your mood and/or control of seizures depending on why you are taking depakote. ...Read more

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Is depakote er safe? I'm taking 500mg at bedtime. Is that considered a low dose for someone who is 143lbs? Taking it for Bipolar 1 Disorder.

Is depakote er safe?  I'm taking 500mg at bedtime.  Is that considered a low dose for someone who is 143lbs?  Taking it for Bipolar 1 Disorder.

By it self: Yes. The drug level as well as CBC and LFT should be monitored periodically. Discuss other medications you are taking with prescriber and the possible interactions. ...Read more

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Hi I've gt bipolar 2+gt very hyper I don't believe my 750mg depakote helps I've gt fibromyalgia+I gt sore wen I'm hyper+never know how long it lasts?

Hi I've gt bipolar 2+gt very hyper I don't believe my 750mg depakote helps I've gt fibromyalgia+I gt sore wen I'm hyper+never know how long it lasts?

See MD: See your prescribing doctor to discuss concern that Depakote isn't helping your hyper or hypomanic states. Suggest seeing a mental health therapist to explore other ways to address your mood swings. Check with your pcp or doctor treating your fibromyalgia to discuss status and any recommendations for pain relief, eg., physical therapy. Good luck! ...Read more

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I would like to get pregnant in about a year from now. I have bipolar disorder, have been stable 8 yrs take depakote, geodon, (ziprasidone) benzotropine and atiwan.

Weigh risks/benefit: Being stable 8 years shows a lot of effort on your part. The medicines you're taking do have risks in pregnancy. Depakote especially has risk of abnormal spinal cord development in the infant. Geodon's risk is unclear. Ativan (lorazepam) is possibly related to cleft palate. You need to work with a perinatal psychiatrist ; a high risk ob-gyn to understand the risks ; explore options to deal with them. ...Read more

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Can a therapeutic effect be achieved with low dosage of geodon? I used to take 1000 mg Depakote and that wasn't working for my bipolar. Increasing the Depakote led to huge hunger and weight gain. My doc decreased the Depakote to 750mg and put me on geod

Can a therapeutic effect be achieved with low dosage of geodon? I used to take 1000 mg Depakote and that wasn't working for my bipolar.  Increasing the Depakote led to huge hunger and weight gain.  My doc decreased the Depakote to 750mg and put me on geod

Depends: Geodon (ziprasidone) most effective dose is the one that produces relief for the patient. The condition being treated may also predict what the dose range will be. As a reminder, Geodon (ziprasidone) must be taken with food to ensure it is absorbed from the GI tract. ...Read more

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My pdoc wants to put me on sodium valporate (depakote) for bipolar. I am worried because of the risk of tardive dyskenisia are my fears justified?

My pdoc wants to put me on sodium valporate (depakote) for bipolar. I am worried because of the risk of tardive dyskenisia are my fears justified?

No.: It will not cause tardive dyskinesia but there are numerous other side effects. You must weigh the risks against the benefits in an intelligent and educated way by discussing with your doctor. And keep an open mind. ...Read more

Lithium (Definition)

Chemically, lithium is a light, soft, alkali metal. It's very highly reactive, so that in nature it's only found in compound form. It's useful in batteries. As a medication, Lithium Carbonate and citrate can be used to stabilize mood in people with bipolar disorder. In these people it can help with both mania and depression. Blood level monitoring is ...Read more


Depakote (Definition)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more