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Doctor insights on: Depakote Safe Women Pregnant

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Is Depakote ER safe for women who are pregnant or breastfeeding?

Is Depakote ER safe for  women who are pregnant or breastfeeding?

No: Depakote (valproic acid) is a pregnancy category d, which means that the medication has been show to be associated with fetal abnormalities. Depakote has been shown to increase the risk if spina bifida (spinal defects), and other abnormalities. Not recommended with breastfeeding. ...Read more

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Dr. Jeffrey Cohen
245 doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, ..Etc.It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more


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I was on Depakote for 6 years, now I am pregnant. Could that have an effect on the pregnancy tests I have taken?

I was on Depakote for 6 years, now I am pregnant. Could that have an effect on the pregnancy tests I have taken?

Depakote unlikely...: Depakote would be unlikely to affect your results. What I am not clear on is why you did 5 pregnancy tests? Once you have a single positive test, and the symptoms of pregnancy i would assume you are pregnant. Especially if this is confirmed with ultrasound. Some tests are more sensitive to HCG than others and very close to the expected period some may be negative and the others positive. ...Read more

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I am 8 weeks pregnant. I have taken 5 tests, and two have come positive. I have a lot of symptoms. Could my Depakote not give an accurate result?

I am 8 weeks pregnant. I have taken 5 tests, and two have come positive. I have a lot of symptoms. Could my Depakote not give an accurate result?

Depakote unlikely...: Depakote would be unlikely to affect your results. What I am not clear on is why you did 5 pregnancy tests? Once you have a single positive test, and the symptoms of pregnancy i would assume you are pregnant. Especially if this is confirmed with ultrasound. Some tests are more sensitive to HCG than others and very close to the expected period some may be negative and the others positive. ...Read more

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Hi how long will it take to get Depakote off my wife system before pregnant as she has stopped it this month though with the help of her doctor.?

Hi  how long will  it take to get Depakote off my wife system  before pregnant as she has stopped  it this month though with the help of her doctor.?

Less than a week.: Half-life elimination for Depakote (increased with liver disease): adults: 9-16 hours. That means that within a week after stopping depakote, it is completely out of your system. Your wife should be taking Folic Acid at 4-5 mg daily to prevent fetal anomalies for 6-52 weeks prior to conception! ...Read more

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I am 4 weeks pregnant. I was on 750 mg of Depakote for migraines. I stopped immediately. I am very concerned. Any advise or positive info?

I am 4 weeks pregnant. I was on 750 mg of Depakote for migraines. I stopped immediately. I am very concerned. Any advise or positive info?

Likely okay: Depakote is a known teratogen and can cause congenital malformations as you probably read, in a developing embryo/fetus. If you are 4 weeks pregnant, organs have barely started to form, and you'll likely be okay. Be sure to take 800mcg Folic Acid and speak with your doctor right away so that he/she can add some extra ultrasounds to check for any problems. In addition, may see geneticist to discuss. ...Read more

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I am 41 & 4 weeks pregnant. I have been taking 750 mg of Depakote for the last 2 mo. I stopped when i found out i was preg. I'm concerned & need advise.

The overall: Incidence of an issue is low and i'm sure you have been thouroughly scanned. I'm not sure how you were taking it the last 2 months and stopped when you found out you were pregnant though. Look up mass . General womens psychiatry website and they will tell you the risks of the meds in pregnancy. Good luck. ...Read more

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Took 750 mg depakote, stopped taking at 2 weeks pregnant. Is my baby going to have birth defects? I'm very worried.

Should Be OK: Highly unlikely due to the brevity of the exposure. At least due to the depakote. There are times of embryonic development that carry higher risk , later in the pregnancy. Remember thyere is also a random risk, unfortunately, of problems, but in this case you should be ok. ...Read more

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I would like to get pregnant in about a year from now. I have bipolar disorder, have been stable 8 yrs take depakote, geodon, (ziprasidone) benzotropine and atiwan.

Weigh risks/benefit: Being stable 8 years shows a lot of effort on your part. The medicines you're taking do have risks in pregnancy. Depakote especially has risk of abnormal spinal cord development in the infant. Geodon's risk is unclear. Ativan (lorazepam) is possibly related to cleft palate. You need to work with a perinatal psychiatrist ; a high risk ob-gyn to understand the risks ; explore options to deal with them. ...Read more

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I just found out i'm 6 weeks pregnant i'm taking lithium Zoloft Depakote and dulera (formoterol and mometasone) inhaler need help on what I should do?

Call your doctor: Call your doctor. If it is not during regular business hours, you can leave a message for someone to call you as soon as possible. If you feel like you need to get professional advice sooner, please go to a hospital emergency room to talk to someone. ...Read more

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Missed period last month.got it a week late this month bleeding 12 days now.(while on yaz 'active pills')can depakote cause this?Not pregnant.thank u!

Missed period last month.got it a week late this month bleeding 12 days now.(while on yaz 'active pills')can depakote cause this?Not pregnant.thank u!

Drug interactions: Depakote can affect the metabolism of medications by your liver. If can cause your Yaz pill to not be effective, and this may be why you are having bleeding. You should definitely talk to your doctor about possible interactions, and see if you need a dose adjustment. ...Read more

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How long do you have to be off of Depakote to get pregnate?

How long do you have to be off of Depakote to get pregnate?

Depends: The time can vary depending on one's current Depakote level, type of Depakote (such as er) and if there is any liver impairment. To be on the conservative side, i would say 10 days or possibly sooner. ...Read more

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Could the medication 'divalproex sodium' or 'topiramate' affect an at home pregnancy test result cuz im 5 days late and it's negative i'm never late?

Could the medication 'divalproex sodium' or 'topiramate' affect an at home pregnancy test result cuz im 5 days late and it's negative i'm never late?

Trust the test: Home pregnancy tests are very accurate and this medication will not affect the test. They are the same tests used in a doctors office. They can detect a pregnancy 7-10 days after conception. The best time to take one is when you miss your period. If you doubt the result you can repeat it in 1-2 days. If you were pregnant the hormone level would rise enough for detection. ...Read more

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Does xenical safe with depakote?

Does xenical safe with depakote?

Yes: Depakote should not be taken with food, as food decreases the absorption of the depakote. Xenical should be taken with a meal. There is a strong possibility that xenical will decrease the absorption of Depakote if taken together. Both medications are metabolized in the liver, therefore, close monitoring of liver function is essential. ...Read more

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Is it safe 2 take coq10 w/ depakote?

Yes: Yes. The metabolism of the two compounds are unrelated, so no interference. ...Read more

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What over-the-counter pain medication is safe to take after a D&C while taking Depakote?

Safe medication: You may take acetaminophen but not more than 4000 mg a day which would be 650 mg every 4 hours( that would make 3900 mg/day) or 1000 mg every 6 hours. Ibuprofen, naproxen and the like interact with Depakote by increasing the changes of bleeding( decreasing platelet count). Some people still take those together but under close supervision by their doctor. ...Read more

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Can you take Depakote and Topamax (topiramate) together? Is 500mg Depakote safe with 50mg of Topamax (topiramate)?

Can you take Depakote and Topamax (topiramate) together? Is 500mg Depakote safe with 50mg of Topamax (topiramate)?

Yes & yes, BUT...: ...you didn't just wander into a pharmacy and made an impulse purchase. You got Rxs from a doctor for a reason, not just on a whim. Why are you trying to go around him/her? Asking anyone other than the MD who knows you and who knows the rationale for your treatment is unwise at best and dangerous at worst. You are entitled to an explanation in terms you understand FROM YOUR DOCTOR. ...Read more

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As a young woman taking depakote, are there any advisories you would have toward my health? I've read that it can affect the reproductive system.

As a young woman taking depakote, are there any advisories you would have toward my health? I've read that it can affect the reproductive system.

Several risk factors: The medicine can promote ovarian cysts, imbalance female hormones, and affect metabolism of carnitine. If you were to become pregnant, definite chance of baby having spina bifida, and also mental retardation. More common side effects include weight gain, hair loss, tremors. Would suggest meeting with your doctor and discussing this thoroughly. ...Read more

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Taking Depakote ER for migraines and would like to stop. Is this safe?

Must be careful: Yes, it is safe- but keep in mind: This is normally done slowly. Depending on what dose you use, the amount you take is gradually reduced over weeks, to prevent the risk of a withdrawal effect, such as nausea or a seizure. For example, if you use 500 mg twice a day, a typical reduction would be to 250 mg twice a day for one week, then 250 mg once a day for one week, then stop. ...Read more

Dr. Sandra Eleczko
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


Depakote (Definition)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more