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Doctor insights on: Depakote And Liver Problems

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Dr. Tanya Russo
2 Doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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Can Depakote harm your liver and stomach?

Maybe: Depakote may affect the liver in some patients. Md may monitor your liver enzymes as a guide. Certain formulations of Depakote may affect the stomach. Discuss with your md. Taking medication with food may help. ...Read more

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I have been taking Depakote and Effexor (venlafaxine) for a lil over a decade, worried abouy my liver will detoxing help it and if yes, what are the best ways?

I have been taking Depakote and Effexor (venlafaxine) for a lil over a decade, worried abouy my liver will detoxing help it and if yes, what are the best ways?

Get blood test: Liver function can and should be checked periodically by a simple blood test ordered by your doctor. Also, the actual blood level of Depakote and the need for both medicines should be checked periodically. The liver itself is a detoxifier; changing medication or specific medical treatment, if needed, should be advised by your doctor. No home remedy is reliable or recommended. ...Read more

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High SHBG (90) caused by taking Depakote, which I discontinued months ago (seizure-free), for 20 years. Will my liver ever recover?

High SHBG (90) caused by taking Depakote, which I discontinued months ago (seizure-free), for 20 years. Will my liver ever recover?

Possible: There are many different factors involved including other mediations, the health of your gall bladder, or whether you have a fatty liver, etc If you stop the Depakote and take no other meds or alcohol your liver usually within a year will heal itself So continue a good diet and monitor your other meds, avoid alcohol, and recheck every 6 months ...Read more

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Can I take ocassional acetaminophen 500-1000 mg if I've hepC, but liver tests are normal and I also take depakote ER 1000 mg/d.?

Can I take ocassional acetaminophen 500-1000 mg if I've hepC, but liver tests are normal and I also take depakote ER 1000 mg/d.?

Most likely: Although you should clear it with your liver doctor, occasional use of acetaminophen does not cause harm to the liver. If used on a regular basis, however, it can be harmful. Have you seen your doctor yet concerning treating your hepatitis C? Current treatments are much easier and practically free of side effects, and are much more effective. Check with your doctor. Good luck. ...Read more

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Switched from Trileptal to Depakote ER 1000 mg/d ; I've HCV and Depakote itself is hard on liver, which pain killer should I prefer now? APAP or nsaids

Switched from Trileptal to Depakote ER 1000 mg/d ; I've HCV and Depakote itself is hard on liver, which pain killer should I prefer now? APAP or nsaids

Best ask prescriber: NSAIDS and acetaminophen (APAP, paracetamol) can both cause problems for someone with a damaged liver. Because a specific answer to a specific case would depend on detailed knowledge of medical history/labs/studies/biopsies, this question is best asked of the prescriber of the Depakote, or of the physician treating the hepatitis C. ...Read more

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Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?

Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?

Abilify (aripiprazole) both: Augments the antidepressant effect of zoloft and treats the psychosis. I would start there. Dose will need to be slightly lowered because zoloft can raise Abilify (aripiprazole) levels. I also find that it has very good results in ptsd. My Next Choice would be seroquel. Discuss dosing with your psychiatrist and make sure you are definitely not bipolar. ...Read more

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How does Depakote cause Tardive Dyskinesia or prolonged QT? Also how rare is pancreatitis and liver failure while taking said medication?

TD/LQT & Depakote?: TD is commonly caused with use of some antipsychotics & metoclopramide. Liver toxicity and pancreatitis may occur with Depakote, risk factors for liver toxicity include young age, severe seizures, mitochondrial disorders usually early on in therapy. Close monitoring at the onset of therapy with early detection of symptoms of liver and pancreatic disease will improve the safe use of Depakote. ...Read more

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Atypicals-zyprexa-latuda-seroquel etc. Or anticonvultants-depakote-tegretol-lamictal etc. Which are harder on your liver?

Atypicals-zyprexa-latuda-seroquel etc. Or anticonvultants-depakote-tegretol-lamictal etc. Which are harder on your liver?

Liver function: Medications are often metabolized in the liver and their safety depends on its integrity. Tegretol induces its own metabolism. Depakote increases the amount of ammonia. Zyprexa, seroquel and Latuda (lurasidone) are metabolized by different metabolic pathways by citochrome p450 enzymes. Lamictal is glucuronized. The risk of liver disease due to these drugs depends on the dose of meds and the liver capacity. ...Read more

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Acetaminophen and depakote, both are hard to liver, but there is no interaction between these? Is it safe? Nsaids cause stomach upset and heatburn

Yes, it's safe: As long as you don't use more than 2 gm acetaminophen daily for long term and don't use any other products (eg OTC supplements, alcohol) which may potentially cause liver problems. Thanks ...Read more

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I am diagnosed bipolar. I am being taken off of depacote because I had high liver enzymes and was feeling sick. I notice this sick smell in urine?

I am diagnosed bipolar. I am being taken off of depacote because I had high liver enzymes and was feeling sick. I notice this sick smell in urine?

Liver problems: If your liver is not functioning well, some of the chemicals it's supposed to cleanse your body of could spill into your urine. Maybe you smell ammonia or other things? Liver failure often causes musty-smelling urine. ...Read more

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How can I stop my hair from falling out. No thyroid problems but was taking Depakote which I stopped over 2 months ago. Very frustrated.

How can I stop my hair from falling out. No thyroid problems but was taking Depakote which I stopped over 2 months ago. Very frustrated.

Hair loss: Suggest you see a dermatologist for exam and guidance. There may be other factors for hair loss or lack of regrowth since stopping Depakote. Meantime, cut your stress as much as possible, eat a healthy diet, try to exercise regularly and focus on the positive. Best wishes. ...Read more

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I've had memory problems with Valium and neurontin, which affect gaba, and lamictal and vimpat, (lacosamide) which don't, but not with depakote, which does. Why?

I've had memory problems with Valium and neurontin, which affect gaba, and lamictal and vimpat, (lacosamide) which don't, but not with depakote, which does. Why?

You're an individual: Any medication which treats seizures can potentially affect memory. But when it comes down to it, everyone is an individual, so you might get a side-effect noone else gets or you might avoid a side-effect that everyone else does get. ...Read more

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Can you please discuss Depakote used for?

Sz and HA's: Depakote is approved for both migraine headaches, and epilepsy. It is considered a broad spectrum anti-epileptic drug. It can prevent both migraine headaches, and a variety of seizures if taken on a regular basis. ...Read more

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What class of drug is depakote or depekene?

Valproic acid: Depakote is the better tolerated form of depakene (valproic acid).
Here in the USA, drug is used for epilepsy and migraine control. ...Read more

Dr. Alan Ali Dr. Ali
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What are the chances of dying from overdose of depakote?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What are the chances of dying from overdose of depakote?

Depakote OD: Can cause injury to liver and nervous system and blood, depending on dose and length of time. If taking Depakote regularly, blood levels checks are vital. ...Read more

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Can Depakote cause hallucinations?

Not normally: It has been reported in cases in which encephalopathy occurred. ...Read more

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What causes Depakote blood to fluctuate?

What causes Depakote blood to fluctuate?

Depends: Depakote levels can vary based on when your last dose was in relation to your blood being drawn for your test. They vary by person. Other medications can affect the metabolism of Depakote and intern cause the levels to fluctuate. Various medical conditions also can affect the levels. ...Read more

Dr. Alan Ali Dr. Ali
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What would a Depakote overdose feel like?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Depakote: Depending on dose taken, dizziness, upset stomach, tremors, headaches, etc. ...Read more

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Is Depakote good for ocd?

Is Depakote good for ocd?

Depakote: Usually Depakote helps for mood and anger, impulsiveness. ...Read more

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Does xenical safe with depakote?

Yes: Depakote should not be taken with food, as food decreases the absorption of the depakote. Xenical should be taken with a meal. There is a strong possibility that xenical will decrease the absorption of Depakote if taken together. Both medications are metabolized in the liver, therefore, close monitoring of liver function is essential. ...Read more

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Is Depakote a dopamine antagonist?

Is Depakote a dopamine antagonist?

No: According to our current understanding, Depakote work by altering calcium current, sodium channel, and the synthesis and breakdown of gaba, the main inhibitory neurotransmitter in the brain. ...Read more

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Is it safe 2 take coq10 w/ depakote?

Yes: Yes. The metabolism of the two compounds are unrelated, so no interference. ...Read more

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Can you take ranitidine with depakote?

Likely interaction: Yes, can be done, and if tried, check periodic depakote blood levels. If latter stays within therapy range, should be no profound issues. Discuss management with your doctor. ...Read more

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How different is divalproex vs Depakote er?

Duration: Depakote er is a branded drug which can be taken once daily. Steady drug levels are maintained, and adverse events may be lower due to lack of peaks in the blood stream. There are now generic forms of immediate release "depakote", but these must be used two or three times daily to achieve a consistent effect. ...Read more

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If you take Depakote can it help constipation?

If you take Depakote can it help constipation?

No: Constipation as actually a side effect reported in 1-5 % of patients on oral depakote. The incidence of diarrhea (0.9%) is only seen with the intravenous use of depakote (valproate sodium), and is not the best option for managing constipation. Try increasing water, friuts veggies in take and gradually introduce fiber in diet. If otc remedies are not helpful then see your doctor for evaluation/care. ...Read more

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What can I do about weight gain because of depakote?

What can I do about weight gain because of depakote?

Lifestylemodificatio: Exercise and diet. If the weight gain is to controlled with that then you need to discuss with your prescriber about what would be the best curse of action like changing meds. ...Read more

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Can I take Xanax (alprazolam) and Depakote together?

Can I take Xanax (alprazolam) and Depakote together?

Xanax (alprazolam) & VPA?: There is no formal interaction between these two meds (depakote & Xanax). It's important to only take those psychiatric medications that are prescribed to you by your doc, and review any questions you have with him/her. Talking with your doc will help you determine the best med & treatment regimen for your particular case. Good luck & stay well! :) ...Read more

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Will my hair regrow, now that I've stopped depakote?

Likely: One of the many adverse effects of Depakote includes hair loss. Most of my patients have regained their hair within a month or two after stopping depakote. If no success, see a dermatologist. ...Read more

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What is the difference between Depakote and Lamictal?

What is the difference between Depakote and Lamictal?

Anticonvulsivants: Both Lamotrigene and Valproate are anticonvulsant agents. They have similar actions, mostly sodium channel blockers. Some of the differences are: Valproate is metabolized in the liver, its blood level can be measured, it is more effective in manic states but not depression.
Lamictal has to be increased gradually, is effective in depression, and linked to Steven Johnson syndrome, a serious skin dis ...Read more

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Can you take topomax with Depakote for mood disorders?

Yes, but: The two meds have been used together for numerous epileptic patients, and have minimal drug-drug interactions, and Depakote blood levels can guide dosing. Side effect profile is biggest issue. Topamax: memory and speech, kidney stones, narrow angle glaucoma, metabolic acidosis. Depakote: weight gain (maybe mitigated by topamax), hair loss, tremors, ovarian cysts, pancreatitis, osteoporosis, etc. ...Read more

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Is it ok to take Depakote and xenical at the same time?

Is it ok to take Depakote and xenical at the same time?

Okay doke: There aren't any interactions between these two medicines. ...Read more

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How long after stopping depakote can I try to conceive?

Please repost: Please repost and include the answer to your question given to you by the clinician who prescribed your depakote; or, if you have not asked him/her, please state why not. ...Read more

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How long do you have to be off of Depakote to get pregnate?

How long do you have to be off of Depakote to get pregnate?

Depends: The time can vary depending on one's current Depakote level, type of Depakote (such as er) and if there is any liver impairment. To be on the conservative side, I would say 10 days or possibly sooner. ...Read more

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Can you tell me about the drug called Depakote for bipolars?

Depakote: Depakote is an antiepileptic drug (AED) used to treat seizure disorders, migraine headaches, and the manic phase of bipolar disorders. It is thought that it works by increasing the concentration of the neurotransmitter gamma-aminobutyric acid (gaba) in the brain. Gaba helps nerves communicate with one another. ...Read more

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Why does my head hurt all the time since stop taking depakote?

Why does my head hurt all the time since stop taking depakote?

Headache prevention: Depakote (valproic acid) is one of several medicines that can reduce the intensity and frequency of headaches (including migraines) when taken on a regular basis. Stopping the medicine could cause a re-emergence of prior headaches. ...Read more

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Could Depakote induce hypomania or is my dose not high enough?

Depakote: Idiosyncratic reactions can occur, but no
it doesn't cause hypomania.
Your blood levels may be low. Accordingly it needs adjustment
or you may need an other stabiliser along with depakote. ...Read more

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Can Depakote cause suicidal tendencies in reforming drug addicts?

NO: That is like asking if af bilge pump sunk the titanic.
Ok, now that I have your attention, I applaud''the reforming''.
Ever taken a look beneath the''reforming drug addicts'' part? Why? Because that is where we need to help. ...Read more

Dr. Jeffrey Cohen
249 Doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, . Etc. It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more


Depakote (Definition)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more