Doctor insights on:
Depakote And Liver Problems
Depakote, recently discontinued after 20 years, caused high shbg (thus, low free t). How long before production of shbg by liver returns to normal?
That depends on you:
That depends on you, your healthy, your liver health....
If you want to know more go here:. ...Read more
This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more
Due to the fact I taking depakote&effexor. Will detoxing my liver be healthy? If so what are some healthy safe ways.
I have been taking Depakote and Effexor (venlafaxine) for a lil over a decade, worried abouy my liver will detoxing help it and if yes, what are the best ways?
Get blood test: Liver function can and should be checked periodically by a simple blood test ordered by your doctor. Also, the actual blood level of Depakote and the need for both medicines should be checked periodically. The liver itself is a detoxifier; changing medication or specific medical treatment, if needed, should be advised by your doctor. No home remedy is reliable or recommended. ...Read more
High SHBG (90) caused by taking Depakote, which I discontinued months ago (seizure-free), for 20 years. Will my liver ever recover?
Possible: There are many different factors involved including other mediations, the health of your gall bladder, or whether you have a fatty liver, etc If you stop the Depakote and take no other meds or alcohol your liver usually within a year will heal itself So continue a good diet and monitor your other meds, avoid alcohol, and recheck every 6 months ...Read more
I realize my the doctors make the final call, but generally if I've been on 1000mg of Depakote for 20 years for epilipsy, can I be a living liver donor?
Can I take ocassional acetaminophen 500-1000 mg if I've hepC, but liver tests are normal and I also take depakote ER 1000 mg/d.?
Most likely: Although you should clear it with your liver doctor, occasional use of acetaminophen does not cause harm to the liver. If used on a regular basis, however, it can be harmful. Have you seen your doctor yet concerning treating your hepatitis C? Current treatments are much easier and practically free of side effects, and are much more effective. Check with your doctor. Good luck. ...Read more
Switched from Trileptal to Depakote ER 1000 mg/d ; I've HCV and Depakote itself is hard on liver, which pain killer should I prefer now? APAP or nsaids
Best ask prescriber: NSAIDS and acetaminophen (APAP, paracetamol) can both cause problems for someone with a damaged liver. Because a specific answer to a specific case would depend on detailed knowledge of medical history/labs/studies/biopsies, this question is best asked of the prescriber of the Depakote, or of the physician treating the hepatitis C. ...Read more
Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?
Abilify (aripiprazole) both: Augments the antidepressant effect of zoloft and treats the psychosis. I would start there. Dose will need to be slightly lowered because zoloft can raise Abilify (aripiprazole) levels. I also find that it has very good results in ptsd. My Next Choice would be seroquel. Discuss dosing with your psychiatrist and make sure you are definitely not bipolar. ...Read more
How does Depakote cause Tardive Dyskinesia or prolonged QT? Also how rare is pancreatitis and liver failure while taking said medication?
TD/LQT & Depakote?: TD is commonly caused with use of some antipsychotics & metoclopramide. Liver toxicity and pancreatitis may occur with Depakote, risk factors for liver toxicity include young age, severe seizures, mitochondrial disorders usually early on in therapy. Close monitoring at the onset of therapy with early detection of symptoms of liver and pancreatic disease will improve the safe use of Depakote. ...Read more
Atypicals-zyprexa-latuda-seroquel etc. Or anticonvultants-depakote-tegretol-lamictal etc. Which are harder on your liver?
Liver function: Medications are often metabolized in the liver and their safety depends on its integrity. Tegretol induces its own metabolism. Depakote increases the amount of ammonia. Zyprexa, seroquel and Latuda (lurasidone) are metabolized by different metabolic pathways by citochrome p450 enzymes. Lamictal is glucuronized. The risk of liver disease due to these drugs depends on the dose of meds and the liver capacity. ...Read more
Acetaminophen and depakote, both are hard to liver, but there is no interaction between these? Is it safe? Nsaids cause stomach upset and heatburn
I am diagnosed bipolar. I am being taken off of depacote because I had high liver enzymes and was feeling sick. I notice this sick smell in urine?
How can I stop my hair from falling out. No thyroid problems but was taking Depakote which I stopped over 2 months ago. Very frustrated.
I've had memory problems with Valium and neurontin, which affect gaba, and lamictal and vimpat, (lacosamide) which don't, but not with depakote, which does. Why?
Depends: Depakote levels can vary based on when your last dose was in relation to your blood being drawn for your test. They vary by person. Other medications can affect the metabolism of Depakote and intern cause the levels to fluctuate. Various medical conditions also can affect the levels. ...Read more
Yes: Depakote should not be taken with food, as food decreases the absorption of the depakote. Xenical should be taken with a meal. There is a strong possibility that xenical will decrease the absorption of Depakote if taken together. Both medications are metabolized in the liver, therefore, close monitoring of liver function is essential. ...Read more
Duration: Depakote er is a branded drug which can be taken once daily. Steady drug levels are maintained, and adverse events may be lower due to lack of peaks in the blood stream. There are now generic forms of immediate release "depakote", but these must be used two or three times daily to achieve a consistent effect. ...Read more
No: Constipation as actually a side effect reported in 1-5 % of patients on oral depakote. The incidence of diarrhea (0.9%) is only seen with the intravenous use of depakote (valproate sodium), and is not the best option for managing constipation. Try increasing water, friuts veggies in take and gradually introduce fiber in diet. If otc remedies are not helpful then see your doctor for evaluation/care. ...Read more
Xanax (alprazolam) & VPA?: There is no formal interaction between these two meds (depakote & Xanax). It's important to only take those psychiatric medications that are prescribed to you by your doc, and review any questions you have with him/her. Talking with your doc will help you determine the best med & treatment regimen for your particular case. Good luck & stay well! :) ...Read more
Both Lamotrigene and Valproate are anticonvulsant agents. They have similar actions, mostly sodium channel blockers. Some of the differences are: Valproate is metabolized in the liver, its blood level can be measured, it is more effective in manic states but not depression.
Lamictal has to be increased gradually, is effective in depression, and linked to Steven Johnson syndrome, a serious skin dis ...Read more
Yes, but: The two meds have been used together for numerous epileptic patients, and have minimal drug-drug interactions, and Depakote blood levels can guide dosing. Side effect profile is biggest issue. Topamax: memory and speech, kidney stones, narrow angle glaucoma, metabolic acidosis. Depakote: weight gain (maybe mitigated by topamax), hair loss, tremors, ovarian cysts, pancreatitis, osteoporosis, etc. ...Read more
Okay doke: There aren't any interactions between these two medicines. ...Read more
Depakote: Depakote is an antiepileptic drug (AED) used to treat seizure disorders, migraine headaches, and the manic phase of bipolar disorders. It is thought that it works by increasing the concentration of the neurotransmitter gamma-aminobutyric acid (gaba) in the brain. Gaba helps nerves communicate with one another. ...Read more
That is like asking if af bilge pump sunk the titanic.
Ok, now that I have your attention, I applaud''the reforming''.
Ever taken a look beneath the''reforming drug addicts'' part? Why? Because that is where we need to help. ...Read more
Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, . Etc. It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more
Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more