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Doctor insights on: Depakote

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Depakote (Overview)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, weight gain and tremors.


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What causes Depakote blood to fluctuate?

What causes Depakote blood to fluctuate?

Depends: Depakote levels can vary based on when your last dose was in relation to your blood being drawn for your test. They vary by person. Other medications can affect the metabolism of Depakote and intern cause the levels to fluctuate. Various medical conditions also can affect the levels. ...Read more

Depakote (Overview)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, weight gain and tremors.


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Please describe the medication: depakote?

Please describe the medication: depakote?

Seizure medication: Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, weight gain and tremors. ...Read more

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Dad 54 yrs old prescribed seroquel, resperdine for 30 days & Depakote for 40 days after 2 weeks of hospitalization for bipolar manic. Now normal & still have Depakote for 7 days. Wt medication should he take after tat or will he be normal without medicati

Dad 54 yrs old prescribed seroquel, resperdine for 30 days & Depakote for 40 days after 2 weeks of hospitalization for bipolar manic. Now normal & still have Depakote for 7 days. Wt medication should he take after tat or will he be normal without medicati

Contact Physician: Considering the recent episode of hospitalization, it would be important to remain on medication consistently. It will important for your father to contact his prescribing physician to set up an appointment to evaluate the current medications and make plans for continued care. ...Read more

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Anxious, depressed, asocial, moody but antidepts made me even more sluggish. Was prescribed depakote, it makes me more balanced&calm. Do I have cyclothymia?

Anxious, depressed, asocial, moody but antidepts made me even more sluggish. Was prescribed depakote, it makes me more balanced&calm. Do I have cyclothymia?

Possibly, not surely: It is possible that you have cyclothymia, but trying to diagnose by responses to medicines may not be accurate. I'm glad you're feeling better, regardless -- but I hope you'll consult a board-certified psychiatrist if you haven't already. Better to work with someone who can review your personal history, family history, medical history, etc to have more reliable diagnosis. Good luck! ...Read more

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Do people use Depakote for impulsive behavior disorder?

Do people use Depakote for impulsive behavior disorder?

Sometimes: "impulsive behavior disorder" is not an official diagnosis. But Depakote is sometimes used for impulsivity associated with bipolar disorder, intermittent explosive disorder, and other psychiatric disorders. If the impulsivity is part of adhd, Depakote would not be a typical treatment. ...Read more

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Can you please discuss Depakote used for?

Can you please discuss Depakote used for?

Sz and HA's: Depakote is approved for both migraine headaches, and epilepsy. It is considered a broad spectrum anti-epileptic drug. It can prevent both migraine headaches, and a variety of seizures if taken on a regular basis. ...Read more

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Is valproate acid (depakote) effective for treating bipolar mixed depressive states?

Is valproate acid (depakote) effective for treating bipolar mixed depressive states?

Yes.: Bipolar disorders are complex to understand and to treat. Combining proper medication with therapy is ideal ...Read more

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Can a mood stabilizer like Depakote or lithium for bipolar disorder works only for the manic episodes?

Can a mood stabilizer like Depakote or lithium for bipolar disorder works only for the manic episodes?

Yes: In fact, we have far better treatments for mania than we do the depressed side of this illness. We are all hoping that better treatments for bipolar depression will be found. ...Read more

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Does xenical safe with depakote?

Does xenical safe with depakote?

Yes: Depakote should not be taken with food, as food decreases the absorption of the depakote. Xenical should be taken with a meal. There is a strong possibility that xenical will decrease the absorption of Depakote if taken together. Both medications are metabolized in the liver, therefore, close monitoring of liver function is essential. ...Read more

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What weight loss medication can you safely take with Depakote if it caused weight gain?

None: There are no proven safe weight loss medications out there. Good diet and exercise are the answeer, as always. ...Read more

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My doc put me on Zoloft (sertraline) 100mg & I'm on trazodone 100mg, depakote, riperidal and serqaul are those meds dangerous for me to take together?

No: If your dr prescribed it this way. Risk/benefit ratio probably justify this (not so uncommon) combination. Ask your dr for the rationale behind it; if it works for you and you have no collateral effects, it is ok. Best wishes. ...Read more

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Depakote for 6 mo. My soft thick hair now thin and coarse. Off the Depakote for 4 months now, what should I do to get my hair back to the way it was?

Selenium: Helps with hair breakage from Depakote. You might want to
have your thyroid and cortisol levels checked as well. Your hair stylist may have insights into other things you can do. Doctors that specialize in complimentary medicine and optimal health can go one step further. Assays can be done on hair samples for amino acid, vitamin and mineral deficiencies and toxicities (somewhat expensive) ...Read more

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Started Depakote last week. Had my normal period 2 weeks ago, yesterday I started again. Is this a normal side effect of depakote?

Can be a side effect.: Irregular menses can be a side effect of depakote. I would be sure to use a good birth control method while you're on this medication. If you're irregular menses persist, then I would see your doctor to discuss it. ...Read more

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How long can it take for Depakote to leave your system?

Usually very brief: If you are taking the er form, would be gone within 5-7 days, but the common ir form, blood levels start dropping after 8-12 hrs, and likely no effect within 2 or 3 days. ...Read more

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My daughter was on 500 mg of Depakote for 5 months...Went off cold turkey and has some dizziness, fogginess, and headaches. How long will last?

Hard to Say: Hard to say. It is possible that the medication was controlling those symptoms. Did you discuss this with the presribing doctor. If not you really need to do so. ...Read more

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300mg daily of lithium for 2 months now. Since then my quality of life is worse. Too soon to drop? Not doubled dose added Depakote because of thyroid

300mg daily of lithium for 2 months now. Since then my quality of life is worse. Too soon to drop? Not doubled dose added Depakote because of thyroid

Confusing: Lithium can cause people to feel not so great but it's hard to tell if you could instead use more to feel better. Depakote can also make you feel not so good but I would have the same concerns as with the lithium. 300 mg. Lithium sounds like a lot but in fact is a low dose and I would be surprised if that's the cause of the low thyroid, though possible. Ask your doctor and good luck! ...Read more

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Do some of the effects of Depakote on fetus wear off over time?

Avoid in pregnancy!: Depakote should be the last drug to be considered for epilepsy therapy in pregnancy because of its strong embryotoxicity and causal relationship with severe fetal anomalies (ranging from anencephaly and myelomeningocele to valproic acid embryopathy). ...Read more

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How long does it take to reach the therapeutic blood level for depakote?

Depends: To reach a steady state level you must wait for a least 5 half-lives of the drug (9->16 hours). If the level is subtherapeutic, the dose needs to be increased and the same process repeated. The dose can be increased by 250 mg 2->3 times /day, depending on how often it is taken. Many drugs interact with Depakote affecting its metabolism. You should have informed your doctor of all your medications. ...Read more

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Acetaminophen and depakote, both are hard to liver, but there is no interaction between these? Is it safe? Nsaids cause stomach upset and heatburn

Acetaminophen and depakote, both are hard to liver, but there is no interaction between these? Is it safe? Nsaids cause stomach upset and heatburn

Yes, it's safe: As long as you don't use more than 2 gm acetaminophen daily for long term and don't use any other products (eg OTC supplements, alcohol) which may potentially cause liver problems. Thanks ...Read more

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I have hypothyroidism because of been on lithium, and now doc added Depakote in combination, I'm concerned of my potential weight gain, any advice?

Weight gain w/meds: Yes, lithium and Depakote can lead to weight gain. I see that you're also on seroquel, (quetiapine) or is that in the past? You can guard against weight gain by being very aware of your food plan and adding daily exercise. Avoid processed foods & alcohol, limit carbs & sugars, eat plenty of fruits & veggies, lean proteins, etc. Since you know of the potential problem you can beat it. Stay healthy! ...Read more

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I take Depakote for my bipolar 2 disorder will taking a mix of creatine and arginine have any side effects?

Why: Not sure why you would be taking arginine and creatine. Frolic acid and omega 3 supplementation are helpful. Any combination of medications prescribed or otc should be used with caution. Make sure you tell your doctor about all therapeutic substances you are taking so they can help monitor your mood and/or control of seizures depending on why you are taking depakote. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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What are the chances of dying from overdose of depakote?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What are the chances of dying from overdose of depakote?

Depakote OD: Can cause injury to liver and nervous system and blood, depending on dose and length of time. If taking Depakote regularly, blood levels checks are vital. ...Read more

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How much and for how long should I take Biotin, Selenium and zink for hair loss/damage due to previously taking Depakote?

How much and for how long should I take Biotin, Selenium and zink for hair loss/damage due to previously taking Depakote?

Nutrition: Depakote and other similar medications can deplete B vitamins and other nutrients. These can be measured in lab tests to determine if supplements are effective.
Hair loss can also occur to hormonal imbalance, heavy metal toxicity and thyroid conditions. ...Read more

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My husband has epilepsy and is on topamax, (topiramate) depakote, and felbatol. Isn't that too many medications?

Epilepsy treatment: If that is the medication regimen that works to keep his seizures under control then it is appropriate. If you still have questions I would recommend you get a second opinion from another neurologist. ...Read more

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Is Depakote stored in fat?

No: Depakote is metabolized almost exclusively by the liver via glucuronide conjugation and mitochondrial beta oxidation. It is excreted in the urine. Further information: http://dailymed. Nlm. Nih. Gov/dailymed/lookup. Cfm? Setid=ded64147-7a43-4055-accc-2c011828079d ...Read more

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Please describe the medication: depakote?

Seizure medication: Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, weight gain and tremors. ...Read more

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Can you please discuss Depakote used for?

Sz and HA's: Depakote is approved for both migraine headaches, and epilepsy. It is considered a broad spectrum anti-epileptic drug. It can prevent both migraine headaches, and a variety of seizures if taken on a regular basis. ...Read more

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How long does Depakote stay in the system?

How long does Depakote stay in the system?

It varies: Normally accepted half life is 4-16 hours but one recent study reported 40 hour.
This means 1/2 of the total in your system should be gone in up to 40 hours. Another 1/2 of whatever is left will take another 40 hours and so on. So there is no one clear simple answer. Best guess is that it will probably be gone by 10 days but could be sooner. ...Read more

Dr. Jeffrey Cohen
249 Doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, . Etc. It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more