Doctor insights on:
Denosumab: Denosumab is an excellent treatment for persons with a low bone mass and at increased risk of fracture. These fractures occur much more often in folks twice your age so you need to have an extensive workup to find out why you might need a drug to prevent bone loss and actually increase your bone health. ...Read more
Treat osteoporosis: Denosumab is an antibody that works in a way similar to bisphosponates (like fosamax) to decrease bone turnover and decrease the risk of fractures in people with osteoporosis who have had a previous fracture. Studies suggest that it is more effective than bisphosphonates. In your age group, unless you have severe osteoporosis or a previous fracture, you would not be a candidate for it. ...Read more
70 yo female w/osteoporosis and family hx of BRCA breast cancer. Ok to Denosumab and Reloxifene therapy together??
Yes it is OK: You can take these medicines together. There is no significant interaction or harm. So relax and take them as advised by your doctor. ...Read more
Dad has advanced prostate cancer with bone metastasis. After orchirectomy, psa down from 270 to 10. Shall he start zometa or xgeva (denosumab)? Which is better?
Prolia: Both medications are anti-resorptive, meaning they prevent breakdown of your bone. Reclast (zoledronic acid) has been used for longer so has more side-effects that are known. It also can not be used if you have kidney problems. Prolia is an injection every 6 months (vs. 12 months with reclast). Both medications tend to be very well tolerated. ...Read more
Which drug would you choose for osteoporosis of hip prolia or reclast (zoledronic acid) what is better tolerated less side effects?
Depends: Both drugs are effective in the treatment of osteoporosis involving the hip. Prolia is likely to work better than reclast, (zoledronic acid) though there are no head to head studies comparing the two. Prolia is typically used in people who have had a previous fracture (spine, wrist), or have very severe osteoporosis. Both are well tolerated with few side effects. Prolia is given twice yearly, Reclast (zoledronic acid) once yearly. ...Read more
My doctor recommended reclast (zoledronic acid) for" convenience." i'm only concerned about the risks/benefits of a drug. Should i choose prolia or fosomax instead?
Maybe: Prolia represents a new category of osteoporosis treatment that is effective and has convenient twice yearly dosing. It appears much more effective than the bisphosphonates and rivals Forteo with much more convenience. It is expensive if not covered by your insurance. Whether it is best for you or not depends on many factors which would require more information about a specific patient. ...Read moreSee 1 more doctor answer
Only one: Hi. The only active ingredient in Prolia is denosumab, a monoclonal antibody that binds a signaling molecule, RANK Ligand (RANKL), that bone forming cells (osteoblasts) secrete that activates bone resorbing cells (osteoclasts). RANKL activates the osteoclasts to break down bone. Denosumab interrupts that, and preserves bone mass and architecture. ...Read more
Many options: Depending on your personal presentation, including your DEXA (bone density) scan results, your the frax® score (a tool developed by who to evaluate fracture risk of patients) and your vit d and ca++ levels, there are other meds such as fosamex, actonel, boniva, reclast, (zoledronic acid) to name a few. Osteoporosis treatment is important, so i recommend discussing with a provider who is educated in it. Good luck. ...Read more
Hard to say: There are no conclusive studies or test that link onj to the ingesting of bisphosphonates. The IV form is another story but this also depends upon the type of mouth surgery you are going to have and the skill level of the surgeon performing the surgery. ...Read moreSee 1 more doctor answer
Not much: That is statistically different from placebo, though everything under the sun has been reported it is hard to link it to the drug. The one side effect that is different by about2% is infection, do I would not give it to a compromised person or one who had an acting infection. The debate ove osteonecrosis of the jaw continues on. ...Read moreSee 2 more doctor answers
Yes: Even if you take a prescription treatment for postmenopausal osteoporosis, you still have to get enough calcium and vitamin D daily, especially if you are at high risk for fracture. You need both calcium and vitamin D because they help in different ways. Calcium: 1200 mg daily helps keep bones strong & Vitamin D: 800-1000 IU daily enables your body to absorb calcium. ...Read moreSee 1 more doctor answer
Does Alendronate and Prolia produce the same results? I want to choose just taking only one and my t-score is -2.7.
Essentially: There are no good "head to head" trials of the meds so I can not say for sure one does not do slightly better than the other, but the avail studies do not show this. They do work very diff though and some individuals may respond better to one than the other. However, the choice of which to use often has to do with other factors. For example GERD & Barret's Esoph may sway you one way cost another. ...Read moreSee 1 more doctor answer