Doctor insights on:
Why?: Why are you on DDAVP (desmopressin) and why do you want to wean off it? I only treat diabetes insipidus (not the other uses - enuresis and von Willebrand's disease). I'm guessing DI. Why would you want to stop the drug? If you have DI and a normal thirst mechanism with ad lib access to water, you'll survive, but your quality of life will suck. I hate making assumptions though. ...Read more
Neither: The medication actually decreases urine production by mimicing a natural hormone we make to help us hold on to water when we are not drinking much. Once the medication exits the body, the effect is gone and you make as much pee as you would normally. By cutting down on night urine production it helps some kids stay dry through the night. It doesn't cure anything. ...Read more
Manmade v. natural: Vasopressin is the human produced hormone, while the long-acting synthetic analogue of this is desmopressin. But they have very similar effects -- although nothing is as good as the body's own creation. Vasopressin controls blood osmolarity (volume of urine, volume of blood and fluid in the body). ...Read more
Reduce urine amount: It is a synthetic anti-diuretic hormone. Acts on the kidney to reabsorb more filtered water so that less urine is produced. Idea being that the bladder will be able to accomodate a smaller urine volume produced and not reach a threshold where nervous system feels it has to expell urine, whilst subject is sleeping, and result in control of bedwetting. ...Read more
No: Desmopressin is the drug form of a hormone called Vasopressin, secreted from the brain, and which works in the kidney to control fluid balance in the body. It has no value in terms of curing neurogenic disease. It's secretion can be affected by neurologic issues such as head trauma, brain tumor, or brain surgery, depending on the area of the brain affected. ...Read more
Think my dr. Incorrectly diagnosed me with CDI when I actually have NDI since DDAVP (desmopressin) hasn't worked after increasing dose to 1 mg/night. What to do?
Second opinion.: If you ever find yourself questioning a diagnosis given to you by one doctor, a second opinion with a local doctor or with one of us here on HealthTap would be a wise idea. ...Read more
Happens to some: Increasing the dose may help, unless your child or you, if you are the patient, are taking what I have found to be a maximal effective dose of 0.6mg (3 x 0, 2mg tabs). An other approach is to try a bed wetting is to use a bedwetting alarm in combination ddavp, (desmopressin) then try and taper DDAVP (desmopressin) after at least 14 consecutive dry nights have been achieved. Good luck. ...Read more
Yrs ago dxd w/partial diabetesinsipidus-12hr inhosph20depriv test. Tx:ddavp daily helped. Yrs later, di slowly resolved! Now diagnosis w/ lupus/sjogrens. Related?
Very possible: The fact that both conditions are rare makes your question a very decent one. Idiopathic diabetes insipidus may well be associated with autoantibodies i.e. Autoimmunity. Lupus is well known to be an autoimmune disease. Therefore, there seems to be a relation, albeit not well defined one. ...Read more
Can partial central diabaetes insipidus go away or improve? Used to need ddavp (desmopressin) to control. Eventually urine started to concentrate without it. Source
If it does happen I must confess I cannot recall I have that happening.
Hopefully you have done well without for a while.
That said, please bring this to the attention of your doctor who will take your history, examine you, and order labs. ...Read more
Stimulaton test: Patients with type 1 VWD less vw factor than normal people. However, they store vwf normally in the cells that line their blood vessels. This can be released into the blood by certain drugs; one of these is ddavp (desmopressin). In a DDAVP (desmopressin) challenge the vwf level is measured, a dose of DDAVP (desmopressin) is given, and the level measured again to see if it goes up significantly. If so, DDAVP (desmopressin) can be used to control bleeding. ...Read more
Modified amino acids: Vasopressin is a naturally occuring peptide hormone - a chain of Amino Acids linked together. Desmopressin is a synthetic peptide with substitution of two different Amino Acids (cystine at the 1 position is changed to a deaminated form; and the arginine at the 8 position is the d form instead of the l form used in all naturally occuring peptides and proteins). ...Read more