Doctor insights on:
Dcis Breast Cancer Genetic
It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read moreSee 2 more doctor answers
Breast Cancer (Female) (Definition)
Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast on an annual basis. ...Read more
What is the normal timescale
in finding a breast cancer and being operated on? In relation to 5mm of intraductal carcinoma grade 3?
Varies: This can depend on your overall health, your surgical risks, timing of getting a surgeon consultation. Availability of the operating room, scheduling with radiology to localize such a small lesion of 5 mm. Etc. This may take 1-3 weeks to schedule depending on these and other potential factors. ...Read moreSee 2 more doctor answers
In light of the recent article in the ny times on breast cancer would you recommend surgery for a 90 year old woman recently diagnosed with dcis?
Depends: Depends on how good she is at 90 yrs and the size, type of DCIS. "Good-risk" DCIS has small size, low aggressive, and good-looking under microscope. You can leave it alone without surgery. "High-risk" DCIS has large size, aggressive, or ugly-looking. So, surgery (wide excision) may be considered if she functions well. However, radiation or tamoxifen is neither needed nor helpful in elderly. ...Read moreSee 2 more doctor answers
In light of the recent article in the ny times on breast cancer would you recommend surgery for a 90 year old woman recently diagnosed with DCIS?
No, but give choice: The most extensive study of 100,000 pts with DCIS followed over 20 years, the risk of dying , about 3.3 percent was very low, between the group that had lumpectomies with or without radiation and the group that had mastectomies.That said, a young 90 year old,wishing 110 span(OK?), need to be given a choice,since aggressive DCIS upped risk to just 7.8% in 20 yrs,so some opt for no tx,but close ffup ...Read moreSee 1 more doctor answer
In one word unknown : Ductal carcinoma in situ dcis is simply the sleeping cancer cells inside the breast ducts, like a garden hose loaded with cancer cells safe if they are inside the duct , once they are out side then is invasive cancer, ready to spread, cause is unknown at this time, from genetic mutations, braca i & ii age, hormonal uses.Environment , late age pregnancy life style etc are all attributed. ...Read moreSee 1 more doctor answer
Unknown: It is very difficult if not impossible to attribute one factor alone as a cause of breast cancer. A recent study looked at stress levels in breast cancer patients and found the stress scores higher in those with more aggressive cancers, but it's hard to know whether the stress caused the aggressive form or if the aggressive cancer caused more stress. Regardless, stress, obviously, is never good. ...Read moreSee 2 more doctor answers
Long process: While not all dcis will become invasive cancer, many cases will and to date we can not differentiate between those that will and those that won't. Those cases that become invasive, can then spread to lymph nodes or other organs. The latter, breast cancer that spreads to other organs, is stage IV breast cancer. ...Read moreSee 2 more doctor answers
I was told my mom had dcis and it was negative. No chemo . Can you have triple negative breast cancer with dcis? Or is the negative something else?
Perhaps: Today, it is recommended that dcis be tested for er and pr expression to see if hormonal therapy may be beneficial, so the negative might refer to that. "triple negative" refers to er, pr and her-2-neu expression, but her-2-neu is not typically measured on dcis outside of clinical trial. Be sure to clarify this with your surgeon or your oncologist. ...Read moreSee 2 more doctor answers
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
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