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Doctor insights on: Dasatinib

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Whats imatinib mesylate?

Whats imatinib mesylate?

Enzyme inhibitor: This drug, gleevec, (imatinib) is used to treat chronic myeloid leukemia and gastro-intestinal stromal tumors. It acts by inhibiting and enzyme produced by tumor cells. ...Read more

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Adding more chemo dasatinib and carboplatin likely to work?

Adding more chemo dasatinib and carboplatin likely to work?

Restate question: Hi jsalyers9. Can you restate your question with a little more information. What is being treated? What treatments have already occurred? Thanks. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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Are the cancer drugs, gefitinib and tarceva (erlotinib) available?

Are the cancer drugs, gefitinib and tarceva (erlotinib) available?

While gefitinib was: Developed first, it is hard to find in america (iressa (gefitinib)). Erlotinib (tarceva) has more side effects, but a trial showed a survival advantage. Probably more related to the characteristics of the study participants than the drug. These are small molecule, tyrosine kinase inhibitors in the erb family of receptors. Canada and europe has iressa (gefitinib). Erlotinib is in us. ...Read more

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Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Is nexavar (sorafenib) prescribed for hepatocellular carcinoma?

Yes, for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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Is revlimid (lenalidomide) effective for acute myelogenous leukemia?

Is revlimid (lenalidomide) effective for acute myelogenous leukemia?

Possibly: If the leukemia develops out of a myelodysplasia and has evidence of a 5q-, then possibly. But, the results are mediocre at best. Not curative by any stretch but could possibly slow the leukemia down for a short time. Hope this helps. ...Read more

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Mult.Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections.What causes fever?

Mult.Myeloma relapsed  after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections.What causes fever?

Fever could be side : Effects of the chemotherapeutic agents and steroids considering there's no blood infection. Tylenol (acetaminophen) should help control the fever. Follow up with your oncologist. God bless you! http://www.Livestrong.Com/article/36171-herbs-cancer/. ...Read more

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If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

Good Question: Avodart (dutasteride) is extensively metabolized in humans by the cyp3a4 and cyp3a5 isoenzymes. Flomax (tamsulosin) is extensively metabolized, mainly by cyp3a4 and cyp2d6 isoenzymes. Sprycel (dasatinib) is also extensively metabolized by the cyp3a4 isoenzyme but is also a weak time-dependent inhibitor of cyp3a4 and may therefore potentially increase the concentrations of Avodart and flomax. ...Read more

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What is better to treat lymphocytic leukemia gleevec (imatinib) or bone marrow transplant?

What is better to treat lymphocytic leukemia gleevec (imatinib) or bone marrow transplant?

Type of Leukemia?: More details are needed to answer this question, specifically what is the leukemia type? Is it acute lymphoblastic leukemia, chronic lymphocytic leukemia, or are you referring to chronic myeloid leukemia? Please ask this question again with the additional information so it can be answered. ...Read more

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What makes Trovax different from other kidney cancer meds (like nexavar, proleukin, torisel, (temsirolimus) sutent)?

What makes Trovax different from other kidney cancer meds (like nexavar, proleukin, torisel, (temsirolimus) sutent)?

Other drugs worked: Nexavar, torisel, and sutent all received FDA approval because they improved progression free survival. The initial Trovax trial was terminated early because there was little or no prospect of demonstrating a statistically significant survival benefit compared to placebo. http://clincancerres.aacrjournals.org/content/16/22/5539.long ...Read more

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Has anyone taken Xeloda (capecitabine) or zometa for mets?

Has anyone taken Xeloda (capecitabine) or zometa for mets?

These are 2 options: Xeloda (capecitabine) - is an oral chemotherapy drug that can be used for certain metastatic cancers alone or in combination with other chemotherapy drugs as palliative treatment. Zometa - is used in a situation where cancer has spread to the bones. Its not chemotherapy but a bisphosphanate, a medication used to prevent further weakening of bones by cancer and prevent fractures. In some situations both are given. ...Read more

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
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How effective iressa (gefitinib) for lung cancer after chemo?

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
How effective iressa (gefitinib) for  lung cancer after chemo?

Only if ..: Gefitinib will only work if there is a egfr mutation detected on the cancer. It will not be effective if there is no egfr mutation detected. ...Read more

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What is tarceva (erlotinib)?

Targeted therapy: It is a targeted therapy. It is an oral tyrosine kinase inhibitor pill that targets part of the egfr pathway. Recently we have learned that there a several gene mutations that are found in lung cancer. If a patient has a mutation of the egfr system that their lung cancer developed, this drug can be more effective than chemotherapy in controlling their cancer. ...Read more

Dr. Alan Ali Dr. Ali
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Whats camptosar (irinotecan) for?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
Whats camptosar (irinotecan) for?

Camptosar (irinotecan): Is hormonal antineoplastic medication given by injection in treatment of metastatic colorectal cancers. ...Read more

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
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Can doxil (liposomal doxorubicin) treat multiple myeloma?

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
Can doxil (liposomal doxorubicin) treat multiple myeloma?

Yes: Yes, Doxil (liposomal doxorubicin) can be used to treat multiple myeloma. Discuss further in detail with your oncologist -whether the chemotherapy would be appropriate for your case. ...Read more

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Usually average 1 cold per year. None since began taking Sprycel (dasatinib) for CML 4 years ago. Do these TKIs have antiviral properties?

Usually average 1 cold per year. None since began taking Sprycel (dasatinib) for CML  4 years ago. Do these TKIs have antiviral properties?

Congratulations: Dasatinib, like imatinib tyrosine kinase inhibitors are great success in cancer treatment for CML etc.Suppressing abnormal white cells defective in combatting infections may have enhanced your body's normal white cells against colds,etc. These molecules block the TKI molecular switches on cells. They do not have antiviral properties. That said, side effects of TKIs include low blood count,takecare ...Read more

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Effects of leukemia drugs: mylotarg and cytosine arabinoside?

Effects of leukemia drugs: mylotarg and cytosine arabinoside?

Mylotarg-cytarabine: Open these links: http://www.Drugs.Com/mtm/mylotarg.Html http://www.Drugs.Com/mtm/cytarabine.Html.

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Is the drug neulasta (pegfilgrastim) (pegrilgrastim) ever used for hodgkin disease?

Is the drug neulasta (pegfilgrastim) (pegrilgrastim) ever used for hodgkin disease?

Sometimes: Pegfilgrastim (neulasta) is white blood cell stimulant that can be used after chemotherapy to help the white blood cells recover. In some situations it could be used after chemotherapy for hodgkin disease. ...Read more

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Anyone know of effects with gleevec (imatinib)?

Gleevec (imatinib) info: Open this link: http://www.Nlm.Nih.Gov/medlineplus/druginfo/meds/a606018.Html.

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