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Doctor insights on: Danazol For Hereditary Angioedema

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What cause hereditary angioedema?

What cause hereditary angioedema?

HAE: Hereditary angioedema (hae) is caused by a an uncontrolled activation of a complex cascade of proteins called complement. Hae is a result of a deficiency or lack of functional c1 esterase inhibitor protein. Some patients are born with this problem while other may acquire a lack of c1 esterase inhibitor from an underlying disease such as cancer. There are new treatments available. ...Read more

Dr. Douglas Johnston
122 doctors shared insights

Angioedema (Definition)

Angioedema is swelling that occurs under the skin. Hives are very similar but hives occur in the skin layer. Angioedema is due to fluid leaking from blood vessels usually due to an allergy or genetic abnormality. Treatment includes steroids, ...Read more


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When does prophylaxis for hereditary angioedema become necessary?

It depends: Great question. It really depends on two factors: 1. The severity of the reactions, and 2. The frequency of the reactions. When the reactions become too severe and/or too frequent, prophylactic treatment is recommended. Now, what does too severe/frequent mean? It depends on the person. Ultimately, when the reactions impact a patient's daily life, it's time to consider prophylaxis. ...Read more

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Whats hereditary angioedema?

Genetic disorder: HAE is genetic disorder resulting in unpredictable swelling of any part of the body. It is not caused by histamine, but a chemical caused bradykinin. When released in uncontrolled manner the part of the body where this occurs swells. Swelling occurs within 6-36 hours and if untreated resolves in 2-5 days. There is now a replacement enzyme for Type I and II. 4 on demand meds are FDA approved. ...Read more

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Can anyone have hereditary angioedema?

Can anyone have hereditary angioedema?

Yes: Hereditary angioedema types 1 and 2 have a very strong genetic component and typically runs in families. However, spontaneous mutations can occur and hae i and ii can occur on anyone. ...Read more

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What causes hereditary angioedema to occur?

What causes hereditary angioedema to occur?

Abnl or absent prote: Hae is the result of missing or a poorly functioning protein called c1 esterase inhibitor. When this protein is missing or abnormal then a patient may to prone to swelling problems which can be life threatening. ...Read more

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Anyone here treat hereditary angioedema(hae)?

Anyone here treat hereditary angioedema(hae)?

allergists can help: There been exciting and new pharmaceutical options developed for the treatment of acute attacks of hereditary angioedema. Typically board certified allergists are well-versed in the diagnosis and management of hereditary angioedema. ...Read more

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Is hereditary angioedema different from regular angioedema?

Is hereditary angioedema different from regular angioedema?

Allergy or not: Angioedema such as swelling of the tongue or lips can occur as the result of an allergy to food or medication. It is usually associated with hives (urticaria). The presence of hives essentially rules out the allergic cause making hereditary or acquired c-1 inhibitor deficiency likely. However, the lack of hives does not rule out allergy. See an allergist for further evaluation either way! ...Read more

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When would you consider hereditary angioedema attacks serious?

When would you consider hereditary angioedema attacks serious?

Close the airway: Hereditary angioedema is characterized by episodes of tissue swelling in the face, throat, limbs, and abdomen. In most cases, the swelling develops over hours but sometimes it may take only minutes. The most serious attacks swell the throat closed which can quickly cause respiratory arrest & death if not treated. Frequent & unpredictable attacks are also serious and require preventative treatment. ...Read more

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Dr. Suzanne Galli
12 doctors shared insights

Danocrine (Definition)

Danocrine is a women's ...Read more


Dr. Arthur Balin
22 doctors shared insights

Danazol (Definition)

Danazol is a women's ...Read more