Doctor insights on:
Cytoplasmic Fluorescence And Lupus
ANA 250 -Indirect Immunofluoresence Assay with both speckled pattern, elevated ESR, rash with lesions on chest, neck,ears,face - LUPUS ?
Talk to doctor: Although these findings are not incompatible with lupus, the lack of joint symptoms points away from the diagnosis. The diagnosis of nearly all diseases should be made by a doctor and not by lab tests alone. ...Read more
ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?
Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more
Ana direct positive ANA , ifa neg , rnp 2.3, CRP 5.4 ss-b2.7.Diag with lupus connective tissue and sjorgen all at once? Why 2 ANA tests different answ
They can change!: Appears you have mctd with sjogren's like features based on the labs and titers. No lupus marker present! ...Read more
My lab results for ANA lab/test.
CYTOPLASMIC SPECKLING PRESENT. what does cytoplasmic speckling present mean?
RA factor,ANA positive with polyarthritis ACCP negative and polyclonal hypergammaglobulinaemia. whats the diagnosis?
Auto immune disorder: The information you provided is not sufficient to provide a specific diagnosis. It suggest an auto-immune inflammatory disorder. All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. ...Read more
Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read moreSee 1 more doctor answer
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?
Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read moreSee 1 more doctor answer
Immunofluorescence negative but mpo-anca < 2 <20 ru/ml and pr3-anca 3<20ru/ml with IgM kappa monoclonal protein in beta2. What does this mean?
ANA by IFA positive 1280 homogeneous and speckled. ANA ELISA negative 0.7. ENA and compliments normal. Confused as to which is most accurate.
4/5 results- test neg scl70, double stranded dna, ssa, ssb, smith rmp sederate, esr&crp norm, electrolyte/white/red blood norm.Again + ANA 1:160 centromer. What additional test to exclude scleroderma/crest?
Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more
Positive ANA with titer 1:80 Homogeneous AND 1:80 Speckled. What does this all mean? Constant headaches and fatigue. Possibility of Lupus?
May be: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, ANA positive at 1:80 is just above the normal limit and may not mean any disease. It would be prudent to consult a rheumatologist. For info http://www.rheumatology.org/practice/clinical/patients/diseases_and_conditions/ana.asp ...Read more
What does a positive NEUTROPHIL CYTOPLASMIC AB.CLASSIC & NEUTROPHIL CYTOPLASMIC AB.PERINUCL & Antinuclear antibodies mean?
See details: This test must be evaluated in the context of the clinical picture. The pANCA and MPO can be positive in several different diseases. ...Read more
Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?
Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more
ANA explanation: ANA are antinuclear antibodies which are seen in Systemic Lupus and some other disorders. Titer means how many dilutions in the test are still positive. The higher the number the more significant the test is clinically. 1:10-1:40 is low; 1 :80-1:320 is modest;1:680 and higher is high and very significant. Homogeneous is the most non-specific pattern seen even in drug-induced SLE.See your above. ...Read more
Resent blood work states IgM 875, an appearant polyclonal glammopathy IgM, kappa and Lambda light chains appear increased. Possible Multiple myeloma?
No: Myeloma is monoclonal. I trust you do not have urinary light chains. Most polyclonal stuff means nothing. If you are symptomatic, look for another cause of any symptoms. ...Read more
Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.
Need to be evaluated: A low titer (concentration) ANA test is not particularly helpful to make a diagnosis. Even with a particular pattern (speckled) and anti-centromere antibodies and anti-histone antibodies. Your rash and hip pain are more important as well as inflammatory markers like an ESR and a CBC if they are normal or not. See your doctor and ask for a referral to a rheumatologist if you are concerned. ...Read more
I have positive ANA sm, ssa (ro), ssb (la) , ro52, jo-1, sci-70, ribosomal p antibodies what are the levels for each antibody that signify lupus ?
Level not important: If these antibodies are truly positive the degree of positivity is not that important. ...Read more
Gyn did ANA testing (first visit, routine checkup) that came back with pattern "cytoplasmic fluorescence". What does this mean?
Not significant: That pattern has no clinical significance. Why was the test ordered in the first place? ...Read more
Cytoplasmic fluorescence on ANA test in pattern of liver disease, further bloods negative, do I need liver biopsy? Or repeat tests later on?
Doubt it: Cytoplasmic fluorescence usually means nothing. If your physician is not worried, i would not be either. Your physician may order a tube test for anti-ro/ssa, etc., if these relate to the present concern. The workup of elevated liver enzymes / transaminases is too difficult to explain in 400 words -- glad you're taking a proactive approach in any case. ...Read more
Not likely: Why worry about 3 disorders, as you likely possess one unifying diagnosis to explain your problems. A good place to start is with an endocrinologist to deal with diabetes and the complications secondary to this. Focus on these issues, and later, if things seem peculiar look into co-morbities. Lastly, if you possess diabetes and lupus, doubt you have ms in addition. ...Read more
Both my mom and aunt have been diagnosed with lupus, should I get checked for it as well? Since I know it’s hereditary
Rheumatologic issues: The specific diagnosis of lupus wouldn't run in families as much as the tendency towards rheumatologic conditions in general - that tendency runs in families - lupus, rheumatoid arthritis, Sjögren's syndrome, scleroderma. Can find all of these in family lineages. Have a good history/physical exam/blood testing coordinated by Rheumatologist. ...Read moreSee 1 more doctor answer
Is it ok for s.l.e lupus patients to take suppliments for gym workouts such as, Karbolyn xr3, stance bcaa, gluamatic
My dsdna double strand reference was 3.45 and very symptomatic.. S this a positive for lupus how is it scored?
Possibly: this is one of the many blood tests used to diagnose lupus..you should consult your rheumatologist to have them run a full battery of tests ...Read more
This last 2 weeks feel so run down between p.O.T.S and lupus... Im 27 i want to feel normal. But i don't think ill ever be "normal" again. :/?
See below: Go the lupus foundation of america's website to find a support group for lupus patients near you. I think you would find this beneficial and you would also learn how other patients cope with the disease. ...Read more
Can I have Lupus if my ANA is positive, tired is 1:320 homogeneous diffuse, but ENA panel is negative. I do have some s/s?
ANA 1:320: Not all autoimmune disease are totally differenciated into discrete diseases and also markers may appear over time, not initially . What was your double stranded DNA? Complement levels? Rheumatoid factor? Can get false positive ANA from RA, mono , Crohns, viral infection, thyroiditis(check TPO,), meds , silicon implants and 5% healthy. f/u w/ rheumatologist ...Read moreSee 1 more doctor answer
I have vonwillebrands disease and lupus (sle). Is it to dangerouse for me to travel out of the u.S. To a disease infested, poverty sticken country?
Immune regulation: One's immune system requires a control center (regulatory lymphocytes etc) to keep it in balance. When the regulation is impaired, immune disorders such as allergic and autoimmune disorders develop. There is also a strong genetic and hormonal influences. Females or people with family history of autoimmune or allergic disorders are at a higher risk to develop these diseases. ...Read more
Varied therapies: It depends on what manifestations of disease you have . Treatments may include anti inflammatory medications, steroids and many other treatments. These really depend on your symptoms with severe nervous system or kidney disease powerful drugs lime Cytoxan (cyclophosphamide) may also be needed. ...Read more
Complicated: If you have lupus, you should see a doctor specializing in careof that disease. The specialist here would be a rheumatologist. You may have a pcp who is very competent in caring for you, however. You may need to be followed by a dermatologist, nephrologist (kidney doctor) and neurologist. Can't give you the whole enchilada in 400 character space. (google a reputable web site). ...Read moreSee 1 more doctor answer
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