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Doctor insights on: Cytochrome P450 2d6 Genotype

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What is the cytochrome p450 2d6 enzyme system?

What is the cytochrome p450 2d6 enzyme system?

2D6: Cytochrome 2d6 is one of the p450 monooxygenases- a large and diverse group of enzymes that catalyze the oxidation of organic substances. ...Read more

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Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary ...Read more

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Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

After research: Checked in epocrates which is a respected source of drug information showed nothing in the way of interaction between acetaminophen and trileptal. before taking any action check with your doctor and or pharmacist. Good luck ...Read more

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Does vinegar affect any pharmicokinetics via acidity or cyp enzyme inhibition or induction and are there any benefits from drinking vinegar?

No effect: Any specific effects of vinegar would be neutralized by stomach acidity which is much stronger. There is a subset of health alternative advocates who advise vinegar for health benefits but there are no clinical studies and i note that are selling "organic" vinegar at a staggeringly higher price than vinegar in the grocery store. Save your money. ...Read more

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I just took a sickle cell screen and result was negative. Does that mean i'm not a sickle cell carrier-aa genotype?

I just took a sickle cell screen and result was negative. Does that mean i'm not a sickle cell carrier-aa genotype?

Means no Hgb S: This test is specifically looking for HGB s. It will detect sickle trait (hgb as) or sickle cell disease (hgb ss). If the test is negative it means there is no sickle hemoglobin present, but it does not mean aa. There are many abnormal hemoglobins that are not aa, but would also test negative on a sickle screen. ...Read more

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Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

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Is there a genotype for high blood pressure?

Is there a genotype for high blood pressure?

Genotype for HBP: Yes in rare cases there are specific genes that cause high blood pressure. Other clues to genes are: Is there high blood pressure in your family? Do you have a twin with high blood pressure? Are of you African Descent especially African American. But we do not know the genes for most causes of high blood pressure. All genes today appear to involve salt metabolism as does much garden variety HTN. ...Read more

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My sister has hep c genotype 1. Just got it her viral load is very low. What are some holistic things she could do to keep it low?

My sister has hep c genotype 1. Just got it her viral load is very low. What are some holistic things she could do to keep it low?

No alcohol: Avoid any alcohol and avoid getting coinfected with hiv. The immune system works to control the virus so avoiding stress, eating healthy and no tobacco or any drugs may also help. Low viral loads should help lead to higher cure rates with antiviral treatment when she is ready. Low viral load does not predict slower rate of scarring (fibrosis). ...Read more

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What is the cytochrome p450 2d6 enzyme system?

2D6: Cytochrome 2d6 is one of the p450 monooxygenases- a large and diverse group of enzymes that catalyze the oxidation of organic substances. ...Read more

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I recently learned my cytochrome p450 oxidase 2e1 is partially reduced, my gstm1 is absent, and my meh only partially works. What does this mean, how common is it, and how can I improve my detox?

What type of detox: As the field of genetics and epigenetics advances more individuals will become aware of these types of problems. Taken altogether you do not metabolize and detoxify as efficiently which increases risk for disease and especially lung cancer from tobacco. Do not smoke, limit or abstain from alcohol, eat organic whole foods, exercise, avoid unnecessary medications and get help with supplement regime. ...Read more

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Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary ...Read more

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Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

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For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

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Does cytochrome p450 enzyme have anything to do with liver enzymes (ALT, AST)?

Does cytochrome p450 enzyme have anything to do with liver enzymes (ALT, AST)?

Yes - both in liver: cytochrome p 450 is principally in the liver and processes medications protecting the liver from injury alt and ast are liver enzymes that are elevated in liver injury ...Read more

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What is the genotype AC negative means?

What is the genotype AC negative means?

Need more info: To understand your question, we need to know what the test was for. If it was for blood typing, this could mean that you are type A positive and rhesus C negative, which isn't nearly as important as the usual Rh negative, referring to rhesus D negative. ...Read more

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Is there a genotype named AC and if there is can I marry someone whos AA nd B+? I am AC, O+

Is there a genotype named AC and if there is can I marry someone whos AA nd B+? I am AC, O+

Good Match: Genotype AC is called Hemoglobin C trait. People who have it inherit normal hemoglobin called hemoglobin A from one parent and an abnormal hemoglobin called hemoglobin C from the other parent. A person with AC should be healthy, and if somebody like that marries another with AA genotype, half of their children will be AC and half AA. All children should be fine. B+ and O+ are normal blood types. ...Read more