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Doctor insights on: Cytochrome P450 2d6 Genotype

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W 30 yo. low HDL (0.85 vs 1.3 max ), high triglycerides (1,74), neutrophile (8 vs 7,5 max), normal LDL 2.15, hba1c 5.2 and fgp 4,6, TSH 2.23.no medica?

W 30 yo. low HDL (0.85 vs 1.3 max ), high triglycerides (1,74), neutrophile (8 vs 7,5 max), normal LDL 2.15, hba1c 5.2 and fgp 4,6, TSH 2.23.no medica?

Lab data: It is very difficult, if not impossible to interpret lab data in the absence of clinical information or relevance. My advice is to discuss this with the doctor who ordered these tests and not try to self-diagnose over the internet. Best wishes. ...Read more

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What is the cytochrome p450 2d6 enzyme system?

What is the cytochrome p450 2d6 enzyme system?

2D6: Cytochrome 2d6 is one of the p450 monooxygenases- a large and diverse group of enzymes that catalyze the oxidation of organic substances. ...Read more

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In ICU Jan 2016 - toxic granulation, NRBC .3, atyp lymphs 6%. No diagnosis. May 2017 admitted w/ naus/vom. WBC 3.4, RBC 3.6, hgb 8. Any link?

In ICU Jan 2016 - toxic granulation, NRBC .3, atyp lymphs 6%. No diagnosis. May 2017 admitted w/ naus/vom. WBC 3.4, RBC 3.6, hgb 8. Any link?

Not relevant: The link if any with your 2016 admission may not be relevant. You are anemic and that needs to be investigated, along with your other symptoms. It is not feasible to provide a meaningful opinion without taking additional history, physical examination and may be some tests. It would be prudent to see your doctor. Wish you good health! ...Read more

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Blood: creatinine 1.80; GFR 41. Follow-up labs 48 hrs later: creatinine 1.50; GFR 53. Imm% - 1.8; imm count - .16. Wbc normal. No symptoms. 46-w-male?

Blood: creatinine 1.80; GFR 41. Follow-up  labs 48 hrs later: creatinine 1.50; GFR 53. Imm% - 1.8; imm count - .16. Wbc normal. No symptoms. 46-w-male?

Kidney down briefly?: Both are a bit high for a man in his mid-40s especially if your bodybuilding days are over. Might you have been recovering from a subclinical bout of Ibuprofen nephropathy? It's very common and causes partial renal shutdown. Drink plenty of water if you use nsaids nad consider a follow at your next regular appointment. ...Read more

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Triglycerides 453 hi. Glucose 132H.Bun 26H. Hemoglobin 11.7 low. Hematocrit 37.5 L. Mchc 31.2 L. RDW 15.5 H. MICROALB CREAT 240 H. VitD 22 L. Father60 and Diabetic . Rest of Cbc and othere normal. What could this be?

Triglycerides 453 hi. Glucose 132H.Bun 26H. Hemoglobin 11.7 low. Hematocrit 37.5 L. Mchc 31.2 L. RDW 15.5 H. MICROALB CREAT 240 H. VitD 22 L. Father60 and Diabetic . Rest of Cbc and othere normal. What could this be?

Need good care: You need to be under the care of a competent physician who can keep your diabetes under control and find the cause of your anemia, which i suspect is due to iron deficiency from blood being lose somewhere. We can't solve it here. If you have a specific question, let us know. ...Read more

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Normocyt, WNL RDW, anemia-hgb 13, rbc 4.3. PO Fe for 1 yr w/ no improvement. Fe 58, ferritin 15, TIBC 347. Asymptomatic. Thoughts on IV iron?

Normocyt, WNL RDW, anemia-hgb 13, rbc 4.3. PO Fe for 1 yr w/ no improvement. Fe 58, ferritin 15, TIBC 347. Asymptomatic. Thoughts on IV iron?

Too aggressive: With the numbers you're presenting I'm not sure who put the idea of doing IV iron into your thought process. Hb-13 for age 74 isn't far off of expected norms for age. If you want to do SOMETHING check thyroids, serum zinc, serum magnesium, & serum Vitamin D. Eat more spinach, beans, dried fruit, seafood, & poultry. Questions? www.healthtap.com/drsaghafi Use Key Code: PDXFNR to make appointment. ...Read more

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Results: Hep C quant. : 2,802,680 HCV log10: 6.448. Reflex to genotype was unable to determine genotype even though there was sufficient HCV RNA?

Results: Hep C quant. : 2,802,680 
HCV log10: 6.448. Reflex to genotype was unable to determine genotype even though there was sufficient HCV RNA?

Hepatitis C virus: Sometimes it's not possible to determine the genotype of this virus, which thus makes the expected response to treatment more uncertain. This is a 'slippery virus' -there are 11 major genotypes (designated 1-11), and many subtypes (a, b, c, etc.) A hepatologist (GI subspecialist) or an ID doctor who works with Hep C patients can help you. You'll need an established relationship for treatment... ...Read more

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My blood test results: total bilirubin: 1.41 h ast: 40 h alt: 100 h total alk phosphatase: 43 l serum total protein: 7.1 e.R. Said hepatitis?

My blood test results:
total bilirubin: 1.41 h
ast: 40 h
alt: 100 h
total alk phosphatase: 43 l
serum total protein: 7.1

e.R. Said hepatitis?

Let's try this...: I have only a little bit of the story you've shared. Perhaps it's time to see whether the ast and alt get back to normal after two weeks off alcohol and any not-totally-necessary meds you may be taking. If so, this is the start of a healthier life after alcohol. If not, the workup for virus infections, iron overload, wilson's, autoimmunity & need for exercise can begin. Good luck. ...Read more

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Which type of walking reduce body fat fast ? Slow walking to 1hr or speed walking to1/2hr (eg; 3.0 speed at treadmill to 1hr or 5.4 speed to 1/2hr)

Which type of walking reduce body  fat fast ? Slow walking to 1hr or speed walking to1/2hr (eg; 3.0 speed at treadmill to 1hr or 5.4 speed to 1/2hr)

Weight loss: It is not about the type of walking but rather the calories burned. Using your example you will have walked 3 miles in one hour slow walking and 2.7 miles in a 1/2 hour fast walking. Because you went farther slow walking you would have burned more calories and therefore, lost more weight from the longer walk. ...Read more

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My 8yr Son ,WBC 4.73 ,Hgb 13.9 Pit 163. Neut% 68.5 % Neut #3.24. Lymph % 25.6, lymph # 1.21 IGA% 0.200 IGA# 0.010 WBC 3.3 2wk ago. Need for Concern?

What is the reason: For serial testing of his WBC and IgA? Lymphocytes are bit on the lower side, and also the IgA, but those have to be read in context of his clinical picture. You can confer with the doctor who ordered the tests. For a second opinion with a specialist, an allergist/immunologist, ask your doctor for referral if s/he would, also check acaai.org or aaaai.org for an allergist/immunologist in your area ...Read more

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For 58+ F, Hb 10.8, RBC 3.66, PCV 34, MCV 94, MCHC 31, WBC 5.4, Pt 1.8, Iron 57, TIBC 255, TSI 22, RC 1.2, Ferritin 83 indicate which type of anemia ?

For 58+ F, Hb 10.8, RBC 3.66, PCV 34, MCV 94, MCHC 31, WBC 5.4, Pt 1.8, Iron 57, TIBC 255, TSI 22, RC 1.2, Ferritin 83 indicate which type of anemia ?

Mild anemia: Assuming you've had no recent bleeding episodes, these findings could be seen in mild/early anemia of chronic disease. Hgb and Hct are only boarder line low, and iron panel appears within the reference range. Even something as simple as a particularly heavy period could cause mild anemia of this type, though. If you have a chronic medical illness, it could cause this type of anemia. ...Read more

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Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary ...Read more

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2 early MC, heartbeat seen 2nd case, no live birth, turner's synd in fetus 2nd case, karyotyping & immunological tests normal. Way fwd? More tests?

2 early MC, heartbeat seen 2nd case, no live birth, turner's synd in fetus 2nd case, karyotyping & immunological tests normal. Way fwd? More tests?

Maternal fetal medicine: specialist is what you need with your high risk pregnancies, if you don't have one available in your area please seek advice in a teaching hospital ...Read more

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How much strength training should be done to minamize catabolism w/ a 500 cal intake deficit? Would 4 days, 4 exercises, 3-4 sets 8-15 reps be enough?

How much strength training should be done to minamize catabolism w/ a 500 cal intake deficit? Would 4 days, 4 exercises, 3-4 sets 8-15 reps be enough?

If heavy training...: ...i usually have rec 3 sets of 15 each, done in a cycle of exercises, targeting different muscle groups, a cycle of 4 then repeat. Day of rest after hard workout. Do cardio. Also get Ur calories from protein, in the form of whey supplement. Ave body needs 50gms/day. Use sup a little during training, majority after. Cals from fat & carbs also. Remember there's protein in veg, meat, dair, eggs, 2. ...Read more

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Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good medicn?

Today my doctor prescribe a infertility medicns i.E tinidazole , l_methylfolate, chymoral forte, third generation cephalosporin.Is that good  medicn?

Not fertility meds: The medications you are describing are several antibiotics, vitamins and enzymes. None of these are infertility medications. If you are not sure why he/she prescribed them, you should ask your doctor what they are for. ...Read more

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My speram count is pH - 7.7 , volume - 1.5 ml, Speram concentration - 77 mil/ml, Progressive - 30, Non progressive - 40 , Non motile - 30. Plz check?

My speram  count is
pH - 7.7 , volume - 1.5 ml, Speram concentration - 77 mil/ml, Progressive - 30, Non progressive - 40
, Non motile - 30.  Plz check?

Your best option: is to have the results interpreted by your ordering Doctor. The pH and count/concentration seem normal, but the volume seems low and I suspect your motility is low (should be >50% show normal forward movement after 1 hour). Again, your treating physician is best able to discuss the significance of this with you. Good wishes:) ...Read more

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Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

After research: Checked in epocrates which is a respected source of drug information showed nothing in the way of interaction between acetaminophen and trileptal. before taking any action check with your doctor and or pharmacist. Good luck ...Read more

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51 yo male. Mild chf, ef of 50. Kidney failure caused by meds. Creatinine returned to 1.6 after meds stopped. Are my kidneys severely damaged?

51 yo male.  Mild chf, ef of 50.  Kidney failure caused by meds.  Creatinine returned to 1.6 after meds stopped.  Are my kidneys severely damaged?

Some damage: Stage 3 of chronic renal failure consists of egfr 45-59 (3a) or 30-44 (3b).Rememember that egfr is an estimate (more info on egfr) and may require a correction for (black) race. Most patients with stage 3ckd are older and only a minority go on to get more serious kidney disease.Increased rate of heart attacks, strokes. Need to be closely followed by physician.Stage4, 5 are more severe renal failure. ...Read more

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Does vinegar affect any pharmicokinetics via acidity or cyp enzyme inhibition or induction and are there any benefits from drinking vinegar?

No effect: Any specific effects of vinegar would be neutralized by stomach acidity which is much stronger. There is a subset of health alternative advocates who advise vinegar for health benefits but there are no clinical studies and i note that are selling "organic" vinegar at a staggeringly higher price than vinegar in the grocery store. Save your money. ...Read more

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I just took a sickle cell screen and result was negative. Does that mean i'm not a sickle cell carrier-aa genotype?

I just took a sickle cell screen and result was negative. Does that mean i'm not a sickle cell carrier-aa genotype?

Means no Hgb S: This test is specifically looking for HGB s. It will detect sickle trait (hgb as) or sickle cell disease (hgb ss). If the test is negative it means there is no sickle hemoglobin present, but it does not mean aa. There are many abnormal hemoglobins that are not aa, but would also test negative on a sickle screen. ...Read more

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Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

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Is there a genotype for high blood pressure?

Is there a genotype for high blood pressure?

Genotype for HBP: Yes in rare cases there are specific genes that cause high blood pressure. Other clues to genes are: Is there high blood pressure in your family? Do you have a twin with high blood pressure? Are of you African Descent especially African American. But we do not know the genes for most causes of high blood pressure. All genes today appear to involve salt metabolism as does much garden variety HTN. ...Read more

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My sister has hep c genotype 1. Just got it her viral load is very low. What are some holistic things she could do to keep it low?

My sister has hep c genotype 1. Just got it her viral load is very low. What are some holistic things she could do to keep it low?

No alcohol: Avoid any alcohol and avoid getting coinfected with hiv. The immune system works to control the virus so avoiding stress, eating healthy and no tobacco or any drugs may also help. Low viral loads should help lead to higher cure rates with antiviral treatment when she is ready. Low viral load does not predict slower rate of scarring (fibrosis). ...Read more

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What is the cytochrome p450 2d6 enzyme system?

2D6: Cytochrome 2d6 is one of the p450 monooxygenases- a large and diverse group of enzymes that catalyze the oxidation of organic substances. ...Read more

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I recently learned my cytochrome p450 oxidase 2e1 is partially reduced, my gstm1 is absent, and my meh only partially works. What does this mean, how common is it, and how can I improve my detox?

What type of detox: As the field of genetics and epigenetics advances more individuals will become aware of these types of problems. Taken altogether you do not metabolize and detoxify as efficiently which increases risk for disease and especially lung cancer from tobacco. Do not smoke, limit or abstain from alcohol, eat organic whole foods, exercise, avoid unnecessary medications and get help with supplement regime. ...Read more

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Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary ...Read more

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Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

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For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

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Does cytochrome p450 enzyme have anything to do with liver enzymes (ALT, AST)?

Does cytochrome p450 enzyme have anything to do with liver enzymes (ALT, AST)?

Yes - both in liver: cytochrome p 450 is principally in the liver and processes medications protecting the liver from injury alt and ast are liver enzymes that are elevated in liver injury ...Read more

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What is the genotype AC negative means?

What is the genotype AC negative means?

Need more info: To understand your question, we need to know what the test was for. If it was for blood typing, this could mean that you are type A positive and rhesus C negative, which isn't nearly as important as the usual Rh negative, referring to rhesus D negative. ...Read more

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Is there a genotype named AC and if there is can I marry someone whos AA nd B+? I am AC, O+

Is there a genotype named AC and if there is can I marry someone whos AA nd B+? I am AC, O+

Good Match: Genotype AC is called Hemoglobin C trait. People who have it inherit normal hemoglobin called hemoglobin A from one parent and an abnormal hemoglobin called hemoglobin C from the other parent. A person with AC should be healthy, and if somebody like that marries another with AA genotype, half of their children will be AC and half AA. All children should be fine. B+ and O+ are normal blood types. ...Read more