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Doctor insights on: Cytochrome P450 2c9 And Vkorc1

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Dr. Philip Miller Dr. Miller
Family Medicine
43 years in practice
Autonomous University of Guadalajara Faculty of Medicine
1
Dr. Martin Raff Dr. Raff
Internal Medicine - Infectious Disease
52 years in practice
University of Texas Medical Branch School of Medicine
2

2
For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

Dr. Shahid Rafique Dr. Rafique
Internal Medicine
40 years in practice
University of Karachi, Dow Medical College
3

3
Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary ...Read more

Dr. Lisa Rankin Dr. Rankin
ADHD & Autism
21 years in practice
University of Miami Miller School of Medicine
4

4
I recently learned my cytochrome p450 oxidase 2e1 is partially reduced, my gstm1 is absent, and my meh only partially works. What does this mean, how common is it, and how can I improve my detox?

What type of detox: As the field of genetics and epigenetics advances more individuals will become aware of these types of problems. Taken altogether you do not metabolize and detoxify as efficiently which increases risk for disease and especially lung cancer from tobacco. Do not smoke, limit or abstain from alcohol, eat organic whole foods, exercise, avoid unnecessary medications and get help with supplement regime. ...Read more

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Dr. William Schmidt Dr. Schmidt
Internal Medicine
50 years in practice
University of Pittsburgh School of Medicine
5

5
Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?

After research: Checked in epocrates which is a respected source of drug information showed nothing in the way of interaction between acetaminophen and trileptal. before taking any action check with your doctor and or pharmacist. Good luck ...Read more

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Dr. Richard Bensinger Dr. Bensinger
Ophthalmology
48 years in practice
Johns Hopkins University School of Medicine
6

6
Does vinegar affect any pharmicokinetics via acidity or cyp enzyme inhibition or induction and are there any benefits from drinking vinegar?

Does vinegar affect any pharmicokinetics via acidity or cyp enzyme inhibition or induction and are there any benefits from drinking vinegar?

No effect: Any specific effects of vinegar would be neutralized by stomach acidity which is much stronger. There is a subset of health alternative advocates who advise vinegar for health benefits but there are no clinical studies and i note that are selling "organic" vinegar at a staggeringly higher price than vinegar in the grocery store. Save your money. ...Read more

Dr. Randy Baker Dr. Baker
Holistic Medicine
36 years in practice
University of Michigan Medical School
7

7
Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

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Dr. David Sneid Dr. Sneid
Internal Medicine - Endocrinology
37 years in practice
Washington University School of Medicine
8

8
On test cyp for hrt. Test was in low 100s. 2 docs prescribed injections, as no other test product worked. What supplements should I take with regimen?

On test cyp for hrt. Test was in low 100s. 2 docs prescribed injections, as no other test product worked. What supplements should I take with regimen?

No supplements: Only take supplements if you want to waste your money on products that you don't know what's in them or what they will do to you. If you already have gynecomastia, make sure you've had a full endocrine work-up by an endocrinologist. Injections are a poor way to replace testosterone. Other products are generally better. 2% gel almost always increases levels to normal at some dose if taken properly. ...Read more

Dr. Mark Reynolds Dr. Reynolds
Psychiatry
29 years in practice
The Wright State University Boonshoft School of Medicine
9

9
What is the cytochrome p450 2d6 enzyme system?

2D6: Cytochrome 2d6 is one of the p450 monooxygenases- a large and diverse group of enzymes that catalyze the oxidation of organic substances. ...Read more

Dr. Lisa Rankin Dr. Rankin
ADHD & Autism
21 years in practice
University of Miami Miller School of Medicine
10

10
I recently learned my cytochrome p450 oxidase 2e1 is partially reduced, my gstm1 is absent, and my meh only partially works. What does this mean, how common is it, and how can I improve my detox?

What type of detox: As the field of genetics and epigenetics advances more individuals will become aware of these types of problems. Taken altogether you do not metabolize and detoxify as efficiently which increases risk for disease and especially lung cancer from tobacco. Do not smoke, limit or abstain from alcohol, eat organic whole foods, exercise, avoid unnecessary medications and get help with supplement regime. ...Read more

See 1 more doctor answer
Dr. Shahid Rafique Dr. Rafique
Internal Medicine
40 years in practice
University of Karachi, Dow Medical College
11

11
Any way to repair cytochrome p450?Since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary ...Read more

Dr. Philip Miller Dr. Miller
Family Medicine
43 years in practice
Autonomous University of Guadalajara Faculty of Medicine
12
Dr. Randy Baker Dr. Baker
Holistic Medicine
36 years in practice
University of Michigan Medical School
13

13
Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

See 1 more doctor answer
Dr. Martin Raff Dr. Raff
Internal Medicine - Infectious Disease
52 years in practice
University of Texas Medical Branch School of Medicine
14

14
For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

Dr. Michael Perez Dr. Perez
Internal Medicine
33 years in practice
Universidad Central del Caribe School of Medicine
15

15
Does cytochrome p450 enzyme have anything to do with liver enzymes (ALT, AST)?

Does cytochrome p450 enzyme have anything to do with liver enzymes (ALT, AST)?

Yes - both in liver: cytochrome p 450 is principally in the liver and processes medications protecting the liver from injury alt and ast are liver enzymes that are elevated in liver injury ...Read more

Dr. Bert Liang Dr. Liang
Neurology
years in practice
16

16
My muscle biopsy said, "Cytochrome Oxidase: Fibers with total absence of staining." Would that be type IV? What doctor needs to review my report?

My muscle biopsy said, "Cytochrome Oxidase: Fibers with total absence of staining." Would that be type IV? What doctor needs to review my report?

Complex IV: Cytochrome C oxidase deficiency is a rare disorder which is associated with Complex IV in the mitochondria. Patients with this should see a neuromuscular specialist (typically a neurologist) who can help assess the clinical approach. ...Read more

Dr. David Sneid Dr. Sneid
Internal Medicine - Endocrinology
37 years in practice
Washington University School of Medicine
17

17
Whats the half life of testosterone cyp?

Whats the half life of testosterone cyp?

Variable: Extremely variable; anywhere from one to two weeks, but effects decline quickly after about a week or so. ...Read more

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Dr. James Krick Dr. Krick
Urology
32 years in practice
Ohio University College of Osteopathic Medicine
18

18
What is the max dose of testosterone e cyp?

What is the max dose of testosterone e cyp?

Testosterone: Testosterone supplementation is only appropriate for documented low testosterone. Dosage is variable and is titrated to appropriate serum level and not subjective effect. Im injection is the least effective way to maintain steady state serum levels (big peaks and valleys). One should avoid supra-physiologic levels at all cost. ...Read more

Dr. Robert Killian Dr. Killian
General Practice
24 years in practice
University of Utah School of Medicine
19

19
How long will a 200mg.Shot of testosterone cyp last in my system bafore it wears off?

Testosterone Inject: Hi this can vary from man to man. The standard treatment with this dose is once every two weeks. But, you may need your own dosing amount and frequency based upon what your symptoms are or how you feel on this dose. A good relationship with your physician will allow easy dosing frequency and amounts to be personalized for you. ...Read more

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Dr. John Feola Dr. Feola
Internal Medicine
27 years in practice
Georgetown University School of Medicine
20

20
33 old male my testo is 159. What can cause this, how bad is it? Past 7 week injected 1 ml testo and it has lowered. Med was testo cyp grpoil in

33 old male my testo is 159. What can cause this, how bad is it? Past 7 week injected 1 ml testo and it has lowered. Med was testo cyp grpoil in

LOW T EVAL: Low T Evaluation and diagnosis of cause is critical. At 35 it is unusal and needs a through workup exam/labs/testiciular US/ and potentially a brain MRI. You will need regular Monitering of testosterone and PSA levels . Follow up with a through PCP and endocrine consult. Low T can cause symptoms of male menopause =ANDROPAUSE. Including anxiety/depression/insomnia. ...Read more

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