Doctor insights on:
My mother-in-law had a biopsy performed on a lump on her leg and the doctors indicated she had cystic lymphoma which could be serious. What is it?
Lymphoma: There are many types of lymphoma-from the agressive ones to the indolent ones. Each type has different biology and different response to therapy, as well as different prognosis etc. However, in general, lymphoma is a chemosensitive disease and is a radiosensitive disease. Yes, some lymphoma can be cured. ...Read more
T cell lymphoma?: I think you mean t cell lymphoma, a cancer of t cells or thymocytes that can cause lymph gland enlargement, low blood counts, fevers, and sweats. A particular subtype is gamma-delta (the greek letter for d) hepatosplenic lymphoma, which could also be what you're referring to. A good source of information is the leukemia & lymphoma society of america's website. ...Read more
Symptoms and imaging:
People usually present with symptoms -- eg, fever, chills, night sweats, fatigue, lymph node enlargement, spleen enlargement, etc.
Then (or sometimes incidentally) abnormal lymph nodes are noted on ct scans.
A biopsy (of lymph nodes and/or bone marrow) is needed for diagnosis.
Less often blood abnormalities show a leukemic (blood) component of lymphoma or other abnormalities. ...Read more
See below...: The diagnosis and treatment of lymphoma, like any other cancer, should be managed by an oncologist. Many signs and symptoms are possible at presentation including unexplained weight loss, lymph node enlargement, lack of appetite, night sweats, fatigue, prolonged fever, enlarged spleen and/or liver, etc. ...Read more
Lymphoma...: Often, the first sign of lymphoma is a painless swelling in the neck, under an arm, or in the groin. Lymph nodes or tissues elsewhere in the body may also swell. The spleen, for example, often becomes enlarged in lymphoma. Symptoms of lymphoma may include the following: fevers, chills, unexplained weight loss, night sweats, fatigue, and itching. ...Read more
Many variables: Survival and treatment selection depend on many variables: stage of disease, type of lymphoma, age of patient, associated symptoms, overall performance status, specific pathologic and blood based risk factors, as well as response to therapy. It is too broad to cover all aspects specifically so I would refer you to online resources such as acs. Org or institutional web resources like mdacc or mskcc. ...Read more
Could be several: Lymphoma is a general category which includes many subtypes of hodgkins and non-hodgkins lymphomas. They may manifest slowly over years while higher grades progress more quickly. As a class, lymphomas my occur practically anywhere, so the possible symptoms can vary substantially. ...Read more
Yes, it is possible: There are different types of lymphomas which can range from slow growing to rapidly progressive. All lymphomas, even low grade can lead to death if not treated. ...Read more
Are based on their microscopic appearance, expression of proteins on the cell surface, or specific gene mutations.
To name a few: Hodgkins Lymphoma (classical, Lymphocyte rich, etc.). B-cell non-Hodgkins (NHL) include: Lymphoblastic, Burkitt's, Diffuse Large B-cell, Follicular, Mantle Cell, Small Lymphocytic. T-cell lymphomas are yet another group: Anaplastic Large Cell, Angioimmunoblastic, etc. ...Read more
Large lymph nodes: That is the most common symptoms. But it may also include weight loss, fever, drenching sweats, abnormal blood counts, autoimmune problems and compression of organs resulting from the enlarged lymph nodes leading to pain, jaundice, bone fractures or neurological complications. ...Read more
Indolent, persistent: Marginal zone lymphoma is a form of lymphoma that is of low aggressiveness and "indolent." it refers to the cell of origin of the tumor having come from the "marginal zone" of the lymph node, as opposed to "germinal center cell" or "activated b-cell type" cells which are subtypes of the more aggressive "large cell" lymphoma family. It is slower growing, but may be persistent and tough to "cure.". ...Read more
Depends on type: An aggressive lymphoma can actually be cured in many cases but the more slow growing indolent lymphomas have high remission rates but are currently incurable. The above pertains to non-hodgkin lymphoma. Hodgkin lymphoma is almost totally curable in its early stages but less so if more advanced. ...Read more
Often: There are actually maybe a hundred subtypes by now. Some are famously curable -- most of the time. Some can't be cured -- yet -- but these tend to be slow-growers. In the old days, they were all fatal; be thankful for today's medical interventions that actually work. ...Read more
Mantle cell lymphoma: Is a less common b-cell disease in the non-hodgkin's lymphoma group. It tends to be advanced stage when diagnosed, and can have a propensity to involve both the gut and skin. About 20% of cases behave indolently, and treatment is quite effective at diagnosis. Late relapses are common, and treatment is more challenging the second time around. ...Read more