Doctor insights on:
Cystic Fibrosis Male Infertility
Statistically, how successful is IVF with the male partner being a Cystic Fibrosis carrier? Testicular biopsy shows active spermatogenesis.
Autosomal recessive.: Cystic fibrosis (CF) is not sex-linked, but autosomal recessive. That means both parents can be silent carriers--totally unaware--then each passes down this recessive (inactive) gene to their child. This child develops CF because both copies of the formerly inactive gene (1 from each parent) now have no genetic "brake" (normal dominant gene) to prevent the CF gene from expressing itself. ...Read more
Yes: I would use a term "mild" or "atypical" form of cystic fibrosis. Cystic fibrosis is caused by mutation involving cftr gene, and there are a few hundred different mutations. Atypical or mild form of CF manifest at a later age than in infancy as often seen in classic form, and mild in symptoms. ...Read moreSee 1 more doctor answer
Semen analysis: When you have infertility (6 to 12 months of unprotected sex without a successful pregnancy), one of the tests performed is a semen analysis which examines a semen sample for the count, motility and shape (morphology) of the sperm. If the numbers are slightly low that is mild male factor. It is important to discuss your results with your doctor and not just use the lab report. ...Read moreSee 2 more doctor answers
Lung Function: The gene itself will not affect tuberculosis. However, if an individual receives 2 recessive genes of the cftr mutation from their parents, they will develop cystic fibrosis (cf). Because CF can lead to repeated bacterial lung infections (among other things), the lungs would already be in a weakened state if exposed to the causative agent of tuberculosis. This might lead to faster disease onset. ...Read moreSee 1 more doctor answer
In a way: Most patients with diabetes have either a failure of the pancrease (pancrelipase) to produce Insulin or develop resistance to Insulin for various reasons. In cf, there is pancreatic insufficiency due to injury to the pancrease (pancrelipase) from the disease itself... And this can lead to CF related diabetes (where more Insulin is needed). ...Read moreSee 1 more doctor answer
Not always low: Although sometimes it is.Get a more detailed answer ›
Cyst formation: Adenomatoid nodule - fibrotic stroma and glands ( adenoma). When adenomatoid nodule exists for a while and compresses blood vessels and surrounding tissue, hemorrhages and necrosis possible, and finally, in this place tissue degeneration with cyst formation. Example, leiomyomas of uterus sometimes reveal cystic degeration. ...Read more
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