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Doctor insights on: Cystic Fibrosis Carrier Frequency

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Dr. Steven Griggs
9 doctors shared insights

Retroperitoneal Fibrosis (Definition)

Retroperitoneal fibrosis is a rare disorder in which the ureters (tubes that bring urine from the kidneys to the bladder) are blocked by a fibrous mass in the area behind the stomach and intestines. It is ...Read more


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Cystic fibrosis disease is carried by a recessive allele on which gene?

Cystic fibrosis disease is carried by a recessive allele on which gene?

CFTR: Cystic fibrosis is caused by a mutation of the cftr gene, or cystic fibrosis transmembrane regulator, on chromosome 7. Cftr works as a chloride ion channel which helps to regulate chloride and sodium movement in your lungs and sweat ducts. ...Read more

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Is cystic fibrosis a dominant or recessive trait?

Recessive: One needs two defective copies of the cystic fibrosis to develop the disease. ...Read more

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Can a carrier of the Cystic Fibrosis gene ever be symptomatic?

Can a carrier of the Cystic Fibrosis gene ever be symptomatic?

Autosomal recessive: CF is an autosomal recessive genetic disorder. Complete expression of the disease (symptoms) do not typically occur in people who do not have both copies of the defective gene (carriers only have one). ...Read more

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How can the cystic fibrosis gene affect tuberculosis?

How can the cystic fibrosis gene affect tuberculosis?

Lung Function: The gene itself will not affect tuberculosis. However, if an individual receives 2 recessive genes of the cftr mutation from their parents, they will develop cystic fibrosis (cf). Because CF can lead to repeated bacterial lung infections (among other things), the lungs would already be in a weakened state if exposed to the causative agent of tuberculosis. This might lead to faster disease onset. ...Read more

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Dr. Judy Orton Dr. Orton
10 doctors agreed:
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Is cystic fibrosis autosomal dominant in genetics?

Dr. Judy Orton Dr. Orton
10 doctors agreed:
Is cystic fibrosis autosomal dominant in genetics?

Recessive: Both parents must carry the gene with a 25% chance (1:4) with each conception that the baby will have cystic fibrosis. ...Read more

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Is CTFR gene the same as being aCystic Fibrosis Carrier?

Is CTFR gene the same as being aCystic Fibrosis Carrier?

Not necessarily: The CFTR gene, or mutations in this gene, are what are often being tested for in patients suspected of being cystic fibrosis carriers or suffering from the disease itself. If you are a carrier then you will have one copy of your CFTR gene with an abnormality. ...Read more

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Atypical cystic fibrosis life expectancy?

Atypical cystic fibrosis life expectancy?

Depends: Without a full exam and review of medical records and history of infections secondary to CF would be remiss in trying to become an actuarial. Go see a pulmonologist and discuss the options and likely outcomes. ...Read more

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Does gene therapy help a cystic fibrosis sufferer?

Does gene therapy help a cystic fibrosis sufferer?

Trials: Clinical trials for genetic therapy are underway. As of this time there is no approved method for gene tx in cf. Kalydeco, (ivacaftor) a new drug, dose reverse the effects of one subtype of cf, but it dose so by aiding the damaged sodium-chloride transporter to get in proper position and function normally. ...Read more

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Is meconium plug syndrome only associated with cystic fibrosis?

Is meconium plug syndrome only associated with cystic fibrosis?

Not only, but often: No. Certainly patients with meconium plug have a higher risk of CF and must be tested, many babies with this do not have cf. Hirschsprung's disease should also be tested for. ...Read more

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Was diagnosed with cystic fibrosis. What is it like living with cystic fibrosis?

Was diagnosed with cystic fibrosis. What is it like living with cystic fibrosis?

It depends: It really depends on the severity of the disease. Not all patients experience the same symptoms and the same course. ...Read more

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What percentage of female va male fetuses get cystic fibrosis?

50/50: It is about 50/50; there is no real difference in the incidence of cystic fibrosis between males and females. ...Read more

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Why is CF called "cystic" and "fibrosis"?

Old Days: Back in the "old days, " patients with CF would frequently die, and the autopsy findings of the lungs showed scarring ("fibrosis") and bubbles ("cysts, " "cystic"). Thus, it was called cystic fibrosis. We know much more now about this disease, but the old name stuck. ...Read more

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What are the chances of inheriting cystic fibrosis if one parent has trait?

What are the chances of inheriting cystic fibrosis if one parent has trait?

Depends: This depends on the profile of the other parent. Their are dozens of mutations that can lead to CF, although most are the delta 509. Both parents must carry a CF related gene for an offspring to get it, and if so the risk is 25%. Carrier testing is available through specialty labs.If only one has trait ,zero. ...Read more

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Why does cystic fibrosis is obstructive and idiopathic pulmonary fibrosis restrictive? smh

Why does cystic fibrosis is obstructive and idiopathic pulmonary fibrosis restrictive? smh

Cystic fibrosis: involves large amounts of mucus in the airways. Therefore it is difficult for air to flow due to mucus obstructing airways. Pulmonary fibrosis involves diffuse scar tissue in the lung parenchyma, making it difficult to expand (Restrictive). ...Read more

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What does it mean if I am a carrier cystic fibrosis?

What does it mean if I am a carrier cystic fibrosis?

One gene bad: The cftr gene codes for (has information for your body about) a sodium-chloride transporter on your cell membranes. If you have two bad copies you have cf, if you have one, you are a carrier. As many as 1 in 25 caucasian adults in the us has this mutation. If you are planning on having children, talk to your spouse about genetic counseling, unless your spouse is of asian or african descent. ...Read more

Dr. Aaron Milstone
629 doctors shared insights

Pulmonary Fibrosis (Definition)

A lung condition in which there is progressive scarring of the lung tissue. Symptoms include shortness of breath, chest pain, fatigue, ...Read more


Dr. Al Hegab
76 doctors shared insights

Sickle Cell Carrier (Definition)

Sickle cell carrier has gen for disease so if get married with some body with the same gene they will have children ...Read more