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Doctor insights on: Cyproheptadine Hydrochloride Sedating Antihistamine

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For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

Dr. William Singer
34 doctors shared insights

Cyproheptadine Hydrochloride (Definition)

Cyproheptadine hydrochloride is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Which are side effects of periactin (cyproheptadine hydrochloride)?

Which are side effects of periactin (cyproheptadine hydrochloride)?

Some common: Many people experience an increase in appetite (leads to weight gain) and some experience drowsiness. This old antihistamine has been replaced by others that tend to be as effective with less side effects. ...Read more

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Would periactin (cyproheptadine hydrochloride) be used in the same capacity as reactin?

Would periactin (cyproheptadine hydrochloride) be used in the same capacity as reactin?

Reactin vs periactin (cyproheptadine hydrochloride): No they are not similar in any way.Reactin is cetrizine sold in canada under name of reactin, it is once a day allergy medicine, it is second genaration allergy med, and is not as sedating as first generation like benadryl, (diphenhydramine) and periactin periactin is a first generation antihistamine, is sedating and has to be taken 3or4 time a day, generic name cycloheptadine. ...Read more

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Can periactin (cyproheptadine hydrochloride) make you gain weghit!?

Can periactin (cyproheptadine hydrochloride) make you gain weghit!?

Absolutely yes: Periactin (cyproheptadine hydrochloride) (cyproheptadine) is a very effective anti-histamine. It is quite sedating and increased appetite is and associated weight gain are well-known side effects. ...Read more

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How long to develope tolerance to cyproheptadine periactin (cyproheptadine hydrochloride)?

How long to develope tolerance to cyproheptadine periactin (cyproheptadine hydrochloride)?

Highly variable: It may be a few weeks or months but I have one patient with chronic hives who has been on the same dose for over four years. ...Read more

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Are there any alternates similar to periactin (cyproheptadine hydrochloride) (cyproheptadine)?

Could be several but: It depends why you are taking it...This is an antihistamine which helps itching. But, it can make you sleepy, or even hungry(sometimes given to increase appetite). There are several over the counter anti-histamines(which you to be available only by prescription) which are very helpful --allegra, zyrtec, claritin (loratadine). Read the labels and see if they help you. If not check with the dr. Who prescribed it. ...Read more

Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more


Dr. Oscar Novick
37 doctors shared insights

Periactin (Definition)

Periactin is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more