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Doctor insights on: Cymbalta Versus Zoloft

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I'm taking cymbalta (duloxetine) 90mg I want switch to Zoloft 50mg haw can I switch?

I'm taking cymbalta (duloxetine) 90mg I want switch to Zoloft 50mg haw can I switch?

With Doctor's help: One does not treat or manage their own psychiatric medications. This switch if appropriate will happen under the direction of the doctor prescribing for you.

Dr. Heidi Fowler
1,077 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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I'm taking cymbalta (duloxetine) 30mg and Zoloft 50mg I fell very good with that mix is that ok?

I'm taking cymbalta (duloxetine) 30mg and Zoloft 50mg I fell very good with that mix is that ok?

Use with caution: Risperidal, Cymbalta (duloxetine) and Zoloft can interact with each other and on occasion can cause a form of toxicity called the Serotonin Syndrome. These medications elevate serotonin, a neurotransmitter, that enables one neuron (nerve cell) to communicate with another. When mixed together they can cause the serotonin level to go too high. See http://bit. Ly/1CvRfjC Do not stop medication on your own.

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My dr has me on several meds. But im concerned that 120mg of cymbalta (duloxetine) &200mg of Zoloft a day is to much. What is your opinion? ? Please

My dr has me on several meds. But im concerned that 120mg of cymbalta (duloxetine) &200mg of Zoloft a day is to much. What is your opinion? ? Please

Tell your dr!!: Normally there is no reason to take both Cymbalta (duloxetine) and zoloft; the effect on serotonin is duplicated. The only reason I would have someone on both would be if we were making a switch and someone started to feel so much better when one med was added to the other to start a switch and did not feel as good as we lowered the original drug. But you have to let your dr know if you don't feel ok on this!

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If sombody take Zoloft 50mg want switch to Cymbalta (duloxetine) can start Cymbalta (duloxetine) 30mg together for one week then well reduce 25mg Zoloft tell his off zoloft?

If sombody take Zoloft 50mg want switch to Cymbalta (duloxetine) can start Cymbalta (duloxetine) 30mg together for one week then well reduce 25mg Zoloft tell his off zoloft?

Do this under: Medical supervision. You are tapered off the zoloft and simultaneously started on low dose cymbalta (duloxetine). As the zoloft is lowered, the cymbalta (duloxetine) is increased.

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I want switch to Zoloft 50mg I start 25mg Zoloft and cymbalta (duloxetine) 60mg for 5 dayes then cymbalta (duloxetine) 30mg and Zoloft 50mg for 5 dayes then I stop cymbalta (duloxetine)?

I want switch to Zoloft 50mg I start 25mg Zoloft and cymbalta (duloxetine) 60mg for 5 dayes then cymbalta (duloxetine) 30mg and Zoloft 50mg for 5 dayes then I stop cymbalta (duloxetine)?

No treatment Here: As earlier advised it is foolish to act as one's own doctor. Also the doctors on health tap do not provide treatment advice or prescriptions to our readers. You must do this change when appropriate under the care of the physician you see there in canada.

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Would a taper from 60 mg of cymbalta (duloxetine) to Zoloft be difficult?

Possibly: It could be difficult because stopping Cymbalta (duloxetine) can lead to the withdrawal syndrome that some patients experience. It is accompanied by severe migraine headaches and electric current sensations over the the top of the head and the neck and just because sertraline is being started does not necessarily prevent it. Talk to your doctor for more details regarding the transition to zoloft!

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Difference between benefits and side effects of cymbalta (duloxetine) and zoloft?

SNRI vs SSRI: Cymbalta (duloxetine) increases serotonin and norepinephrine levels, zoloft increases serotonin levels only. Cymbala may help chronic pain as well as depression. Both are good antidepressants and have similar side effect profiles. Keep in mind there is no 1antidepressant that is effective for everyone. It may take several trials to find the right one for you or you may be lucky and respond to the 1st one.

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Witch mor interactions with many drugs Zoloft or Cymbalta (duloxetine) and witch more safe between them?

Witch mor interactions with many drugs Zoloft or Cymbalta (duloxetine) and witch more safe between them?

Neither: Well one is not generally safer then the other, it all depends on which works for you. It also depends on what you are treating and what other medications you are on.

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Can I take Cymbalta (duloxetine) 30mg and 25mg Zoloft both together because Cymbalta (duloxetine) good for anxiety and Zoloft help me for deeprtion?

Can I take Cymbalta (duloxetine) 30mg and 25mg Zoloft both together because Cymbalta (duloxetine) good for anxiety and Zoloft help me for deeprtion?

Don't know why: You would want to do that. Cymbalta (duloxetine) can help with both anxiety & depression. Zoloft can also treat both anxiety & depression. Combining them could increase risk for serotoninergic syndrome. See you are also on ativan and risperidal. Please take only as directed by your physician/ psychiatrist.

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Tody was my last day of cymbalta (duloxetine) replace it in Zoloft senc 11day but to day I could not sleep I took ativan and trazadon but I steel can't sleep?

Don't understand...: You don't say how much zoloft (sertraline) and when you are taking it--usually we would cross-taper--start someone on the zoloft (sertraline) and gradually be moving to a therapeutic dose and giving it some time as we move down on the cymbalta (in your case)--how much trazodone did you take, does it normally work for you? It typically takes time to get into one's system and begin to make one sleepy. Talk to your dr asap.

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I switch from cymbalta (duloxetine) 90mg to Zoloft 50mg by tapering cymbalta (duloxetine) but after 10 dayes I finish my last 30 mg cymbalta (duloxetine) but I can't sleep even with trazadon?

I switch from cymbalta (duloxetine) 90mg to Zoloft 50mg by tapering cymbalta (duloxetine) but after 10 dayes I finish my last 30 mg cymbalta (duloxetine) but I can't sleep even with trazadon?

May take longer.: Zoloft and Cymbalta (duloxetine) are actually very different from each other. Cymbalta (duloxetine) is very potent and works on two different receptors (serotonin ; norepinephrine) and many people take longer to get off of it. Zoloft works mostly on one (receptor) and 50 mg is a low dose. Talk to your doctor about this.

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Abilify (aripiprazole) is work better with Cymbalta or zoloft?

It doesn't: Work specifically better with one vs the other. Adding abilify (aripiprazole) to antidepressant can help for recalcitrant depression.

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Why Abilify (aripiprazole) work good with cymbalta and not good with zoloft?

Response varies: Zoloft and Cymbalta work in different ways. This along with individual response may predict my outcomes are different with Abilify (aripiprazole) in combination with either zoloft or cymbalta.

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I'm tapering off Zoloft and switching to cymbalta (duloxetine), (duloxetine) will I lose weight with cymbalta (duloxetine). With out the zoloft? (at the moment I am taking both)

I'm tapering off Zoloft and switching to cymbalta (duloxetine), (duloxetine) will I lose weight with cymbalta (duloxetine). With out the zoloft? (at the moment I am taking both)

Loss of appetite: Both medications have as a side effect- loss of appetite. However, with Cymbalta (duloxetine) is an individual response, you can gain or loose weight. At the same time Cymbalta (duloxetine) is a good antidepressant (snri) and chronic pain relief medication.

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My daughter went to doc she was on cymbalta (duloxetine) 60 she was deepest doc add zoloft 50mg she start to feel good is that oki for doc to do the mix?

My daughter went to doc she was on cymbalta (duloxetine) 60 she was deepest doc add zoloft 50mg she start to feel good is that oki for doc to do the mix?

Doc's the judge.: With these two medications there is a possibility of a major drug-drug interaction leading to what is called Serotonin Syndrome. The doctor must be aware that she is on both medications and weigh the risk/benefits. If they are working, good, but if agitation, rapid heart beat, nausea, hallucinations, fever, incoordination occur call 911. This is an emergency if it happens. Notify the Doctor.

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I'm now taking Zoloft 100mg cymbalta (duloxetine) 30mg for 2wks then I will stop Zoloft and just take cymbalta (duloxetine)... Will this cause weight loss or gain?

I'm now taking Zoloft 100mg cymbalta (duloxetine) 30mg for 2wks then I will stop Zoloft and just take cymbalta (duloxetine)... Will this cause weight loss or gain?

Generally: Some medications don't exactly cause weight gain but if you feel depressed sometimes you don't eat so when you take an antidepressant and start feeling better your appetite comes back and you end up gaining weight. This doesn't always happen but some people treat the weight gain as causal to the medication when in fact its due to improved mood which leads to improved appetite. Just watch what you eat.

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I m in Zoloft 50mg and cymbalta (duloxetine) 30mg and trazadon 25mg I stop cymbalta (duloxetine) and I take trazadon 50mg but I could not sleep what could bi the reason?

I m in Zoloft 50mg and cymbalta (duloxetine) 30mg and trazadon 25mg I stop cymbalta (duloxetine) and I take trazadon 50mg but I could not sleep what could bi the reason?

Not sure: Maybe because you thought the Cymbalta (duloxetine) helped with sleep. It is not a sleeping drug. It is for moods. Maybe it is time to have your trazadone increased, as that medicine is often used for sleeping and you are on a low dose. Fall to your prescribing doctor and don't worry!

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Witch make more sexual problem and lower libido more between Zoloft vs Cymbalta (duloxetine)?

One man's meat....: Another man's poison. Each person is going to respond to the different new anti-depressants in a unique way. Even the same guy at another time. It's complicated and has a lot to do with your confidence in it. This is a decision for your provider, knowing your overall condition, history and other meds. The lists of side effects are pretty alike Talk w/ a trusted provider. Consider talk therapy too.

Dr. Heidi Fowler
1,032 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more