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Doctor insights on: Cymbalta Versus Effexor

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Dr. Alan Ali
Board Certified, Psychiatry
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Dr. Adam Levy
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Effexor (Definition)

Venlafaxine (effexor) is an snri (serotonin and norepinephrine reuptake inhibitor) that is used for the treatment of depression; depression & anxiety; generalized anxiety disorder; & social anxiety. Effexor xr is sometimes used for panic disorders. It can cause nausea, headaches, anxiety, insomnia, drowsiness. & hypertension. Seizures have been reported. Be careful not ...Read more


Dr. Alfred Forrester
Board Certified, Psychiatry
36 years in practice
149K people helped
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How are cymbalta and Effexor XR different?

Different compounds: Cymbalta and Effexor xr are different chemical compounds which are both used to treat depression and anxiety disorders; however, they share a similar "mechanism of action", in that both are serotonin and norepinephrine reuptake inhibitors (snri's). Cymbalta is also used in the management of fibromyalgia and (in europe, at least) urinary incontinence. Their side-effect profiles are also different. ...Read more

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Dr. Adam Levy
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Dr. Jonathan Jassey
Board Certified, Pediatrics
11 years in practice
734K people helped
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My son 18 years old his in Effexor XL not doing well can he take Cymbalta its ok for his age?

My son 18 years old his in Effexor XL not doing well can he take Cymbalta its ok for his age?

Depression/anxiety: Yes that's fine for his age, let his doctor tell you how to start it and get off the effexor. ...Read more

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Dr. Chris Hawley
Board Certified, Family Medicine
18 years in practice
269K people helped
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I've been taking cymbalta 120mg/day for years. It's now very expensive. Is generic Effexor an alternative especially for the chronic shoulder pain?

I've been taking cymbalta 120mg/day for years.  It's now very expensive.  Is generic Effexor an alternative especially for the chronic shoulder pain?

Effexor: Yes Effexor shares many of the same properties as Cymbalta and is much cheaper. Discuss with your doctor who will likely be willing to try it. You have to slowly go up icon the dosing, so don't give up too early if not helping on the starter dose. Your doctor can help you set up a dosing sequence tailor made for you. ...Read more

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Dr. Adam Levy
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Dr. Ravi Chand
Board Certified, Psychiatry
20 years in practice
3M people helped
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Is it safe to be taking cymbalta, Effexor and Valium together?

Is it safe to be taking cymbalta, Effexor and Valium together?

Multiple Psych MEds: Unless there is a strong reason to, Effexor and Cymbalta work by the same mechanism, your risk for blood pressure will increase a lot valium is like xanax but much longer acting to calm anxiety, help with sleep and panic etc. ...Read more

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Dr. Heidi Fowler
Board Certified, Psychiatry
19 years in practice
527M people helped
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I have never been able to achieve an orgasm, i was on Effexor and now am on cymbalta, they are used to treat my fibromyalgia please help me!

I have never been able to achieve an orgasm, i was on Effexor and now am on cymbalta, they are used to treat my fibromyalgia please help me!

If you were unable: To achieve orgasm prior to use of Cymbalta or Effexor - than this goes beyond medication side effect. However, sexual experience can be negatively impacted by depression, fatigue and chronic pain. May wish to explore this issue further with your physician. ...Read more

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Dr. Rhonda Simons
Board Certified, Family Medicine
9 years in practice
757K people helped
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7
Switching from Effexor to cymbalta reduced my drowsiness, after 2 month on cymbalta again i'm drowsy.Tapered dose from 60mg to 30mg last week.Regards?

Switching from Effexor to cymbalta reduced my drowsiness, after 2 month on cymbalta again i'm drowsy.Tapered dose from 60mg to 30mg last week.Regards?

Check MTHFR: Genotype 677 ; 1298. Almost 100% of people treated for depression for extended periods of time are positive for these genes. It is related to low folate ; B12 levels which causes fatigue.Getting treated can help all your meds work much better because your body will finally be able to make its own serotonin, nor-epi, ; dopamine.Tx is safer than placebo-15mg of l-methylfolate, p5p 50mg, 4mg b12. ...Read more

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Dr. Lynne Weixel
Board Certified, Clinical Psychology
30 years in practice
8M people helped
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Does Cymbalta cause weight gain. Also your thoughts on Effexor. Don't want to gain weight and am currently on Wellburin.tx?

Does Cymbalta cause weight gain.  Also your thoughts on Effexor.  Don't want to gain weight and am currently on Wellburin.tx?

Be careful!: Even non-pregnant people need to be very cautious combining Wellbutrin with either of those medications - seizure risk is increased as well as other risks. All anti-depressant seem to result in weight gain for some folk - even ones that cause loss in others. In your case - definitely work w/ your OBGYN to be safe. Try to find a diet plan that will be good for you, your baby and weight control. ...Read more

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Dr. Colin Sanner
Board Certified, Neurology
14 years in practice
588K people helped
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Effexor is known to raise blood pressure...Cymbalta not quite so ..Is this accurate?

Effexor is known to raise blood pressure...Cymbalta not quite so ..Is this accurate?

Correct: While all serotonin-norepinephrine reuptake inhibitors (snris) can raise blood pressure, generally those with more activity on norepinephrine levels (effexor, pristiq, savella) tend to have more effect on blood pressure than cymbalta, which has a 1:1 effect on norepinephrine and serotonin. ...Read more

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Dr. Nicole Carlberg
Board Certified, Psychiatry
13 years in practice
18K people helped
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Effexor vs cymbalta, currently Effexor 225, suffering from somnolence, fatigue.Cymbalta in such case?Best regards for your care.

Effexor vs cymbalta, currently Effexor 225, suffering from somnolence, fatigue.Cymbalta in such case?Best regards for your care.

Psychopharmacology : There are many different small details taken into account when considering medication choices for patients. Effexor and Cymbalta have some similarities. From your brief description it appears as though an appnt is needed with your dr. Make a list of concerns, questions. Bring in your meds, talk about the changes you might want to consider to target your concerns. Schedule extra time if needed. ...Read more

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Cymbalta (Definition)

Cymbalta (duloxetine) is an "antidepressant" medication. However, it is an approved treatment for a variety of indications to include (unipolar) depression, anxiety, and chronic pain (related to diabetic neuropathy, musculoskeletal and/or fibromyalgia). Pharmacologically, it primarily enhances 2 different neurotransmitters (serotonin and norepinephrine). It can cause a ...Read more


Dr. Krishna Kumar
474 doctors shared insights

Venlafaxine (Definition)

It belong to classification of snri antidepressant also help anxiety start slow go slow its approved for depression and anxiety disorder there are some common side effects important never stop suddenly always taper slowly if you ever ...Read more


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Dr. Adam Levy
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