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Doctor insights on: Cymbalta Versus Effexor

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How are cymbalta and Effexor (venlafaxine) XR different?

How are cymbalta and Effexor (venlafaxine) XR different?

Different compounds: Cymbalta and Effexor (venlafaxine) XR are different chemical compounds which are both used to treat depression and anxiety disorders; however, they share a similar "mechanism of action", in that both are serotonin and norepinephrine reuptake inhibitors (snri's). Cymbalta is also used in the management of fibromyalgia and (in europe, at least) urinary incontinence. Their side-effect profiles are also different. ...Read more

Dr. Krishna Kumar
535 doctors shared insights

Venlafaxine (Definition)

It belong to classification of snri antidepressant also help anxiety start slow go slow its approved for depression and anxiety disorder there are some common side effects important never stop suddenly always taper slowly if you ever ...Read more


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Is it safe to be taking cymbalta, Effexor (venlafaxine) and Valium together?

Is it safe to be taking cymbalta, Effexor (venlafaxine) and Valium together?

Multiple Psych MEds: Unless there is a strong reason to, Effexor (venlafaxine) and Cymbalta work by the same mechanism, your risk for blood pressure will increase a lot valium is like xanax but much longer acting to calm anxiety, help with sleep and panic etc. ...Read more

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I have never been able to achieve an orgasm, i was on Effexor (venlafaxine) and now am on cymbalta, they are used to treat my fibromyalgia please help me!

I have never been able to achieve an orgasm, i was on Effexor (venlafaxine) and now am on cymbalta, they are used to treat my fibromyalgia please help me!

If you were unable: To achieve orgasm prior to use of Cymbalta or Effexor (venlafaxine) - than this goes beyond medication side effect. However, sexual experience can be negatively impacted by depression, fatigue and chronic pain. May wish to explore this issue further with your physician. ...Read more

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I've been taking cymbalta 120mg/day for years. It's now very expensive. Is generic Effexor (venlafaxine) an alternative especially for the chronic shoulder pain?

I've been taking cymbalta 120mg/day for years.  It's now very expensive.  Is generic Effexor (venlafaxine) an alternative especially for the chronic shoulder pain?

Effexor (venlafaxine): Yes Effexor (venlafaxine) shares many of the same properties as Cymbalta and is much cheaper. Discuss with your doctor who will likely be willing to try it. You have to slowly go up icon the dosing, so don't give up too early if not helping on the starter dose. Your doctor can help you set up a dosing sequence tailor made for you. ...Read more

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Switching from Effexor (venlafaxine) to cymbalta reduced my drowsiness, after 2 month on cymbalta again i'm drowsy.Tapered dose from 60mg to 30mg last week.Regards?

Switching from Effexor (venlafaxine) to cymbalta reduced my drowsiness, after 2 month on cymbalta again i'm drowsy.Tapered dose from 60mg to 30mg last week.Regards?

Check MTHFR: Genotype 677 ; 1298. Almost 100% of people treated for depression for extended periods of time are positive for these genes. It is related to low folate (folic acid) ; B12 levels which causes fatigue.Getting treated can help all your meds work much better because your body will finally be able to make its own serotonin, nor-epi, ; dopamine.Tx is safer than placebo-15mg of l-methylfolate (folic acid), p5p 50mg, 4mg b12. ...Read more

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Effexor (venlafaxine) is known to raise blood pressure...Cymbalta not quite so ..Is this accurate?

Effexor (venlafaxine) is known to raise blood pressure...Cymbalta not quite so ..Is this accurate?

Correct: While all serotonin-norepinephrine reuptake inhibitors (snris) can raise blood pressure, generally those with more activity on norepinephrine levels (effexor, pristiq, (desvenlafaxine) savella) tend to have more effect on blood pressure than cymbalta, which has a 1:1 effect on norepinephrine and serotonin. ...Read more

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Does Cymbalta cause weight gain. Also your thoughts on Effexor (venlafaxine). Don't want to gain weight and am currently on Wellburin.tx?

Does Cymbalta cause weight gain.  Also your thoughts on Effexor (venlafaxine).  Don't want to gain weight and am currently on Wellburin.tx?

Be careful!: Even non-pregnant people need to be very cautious combining Wellbutrin (bupropion) with either of those medications - seizure risk is increased as well as other risks. All anti-depressant seem to result in weight gain for some folk - even ones that cause loss in others. In your case - definitely work w/ your OBGYN to be safe. Try to find a diet plan that will be good for you, your baby and weight control. ...Read more

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It is said that cymbalta's serotonin to norephinephrine is 1:1..Does that make it an even ratio...And is it then stronger/weaker than effexor/pristiqe?

It is said that cymbalta's serotonin to norephinephrine is 1:1..Does that make it an even ratio...And is it then stronger/weaker than effexor/pristiqe?

Even: Cymbalta has a balanced/even effect on serotonin and norepinephrine, 1:1 ratio of blocking reuptake of both molecules. Technically, that would make it weaker than effexor, (venlafaxine) which has roughly 3:1 norepinephrine to serotonin reuptake inhibition . Clinically however, they are both beneficial for many similar diagnoses, it's just a matter of finding out which is better for each individual. Good luck! ...Read more

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Effexor (venlafaxine) vs cymbalta, currently Effexor (venlafaxine) 225, suffering from somnolence, fatigue.Cymbalta in such case?Best regards for your care.

Effexor (venlafaxine) vs cymbalta, currently Effexor (venlafaxine) 225, suffering from somnolence, fatigue.Cymbalta in such case?Best regards for your care.

Psychopharmacology : There are many different small details taken into account when considering medication choices for patients. Effexor (venlafaxine) and Cymbalta have some similarities. From your brief description it appears as though an appnt is needed with your dr. Make a list of concerns, questions. Bring in your meds, talk about the changes you might want to consider to target your concerns. Schedule extra time if needed. ...Read more

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Was allergic to Effexor XR but helped the most! today tried pristiq (desvenlafaxine) and itching! next i'm trying cymbalta but don't want weight gain! :((((?

Was allergic to Effexor XR but helped the most! today tried pristiq (desvenlafaxine) and itching! next i'm trying cymbalta but don't want weight gain! :((((?

Acctualy… : Cymbalta (duloxetine) has a side effects: loss of appetite, nausea, dry mouth, constipation, tiredness, drowsiness. Constipation is the most common, but adding magnesium to the mix is helpful. The allergic reaction to this drug is also rare. I hope it will be the right medication for you. ...Read more

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How can snri's such as Cymbalta and Effexor (venlafaxine) control anxiety if they work on norepinephrine..would not this increase anxiety?

How can snri's such as Cymbalta and Effexor (venlafaxine) control anxiety if they work on norepinephrine..would not this increase anxiety?

Very right you are!: In my practice I never use these medications, also Wellburtrin and Pristiq, (desvenlafaxine) for anxiety treatment precisely for this reason . And it's not a hypothetical concern as time after time they worsen anxiety in my humble opinion. SSRI's are much more reliable save Paxil (too short acting leading to withdrawal effects). Take care. ...Read more

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I tried celexa, effexor, cymbalta, pristiq, (desvenlafaxine) lexapro, zoloft, wellbutrin, which barely helped. What else could i try? How do u feel about paxil?

I tried celexa, effexor, cymbalta, pristiq, (desvenlafaxine) lexapro, zoloft, wellbutrin, which barely helped. What else could i try?  How do u feel about paxil?

Agree w/Dr. Buggie: I agree with dr. Buggie about the need for psychiatric evaluation and ongoing treatment. Wellbutrin does not help with anxiety. Paxil (paroxetine) is a reasonable choice, but whether it's right for you i cannot say. You're also on Adderall xr, which can exacerbate anxiety in some. Psychotherapy is an important part of treatment for anxiety also -- but you didn't mention pursuing that. ...Read more

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How does cymbalta (duloxetine) compare to venlafaxine tab 75mg?

How does cymbalta (duloxetine) compare to venlafaxine tab 75mg?

Hard to answer: Not sure what dose of Cymbalta (duloxetine) you are referring to. Both medicines affect ne and serotonin, but some people respond better to one medication over the other. It is difficult to compare the antidepressants based on dosages. Everyone responds a bit differently. ...Read more

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Can Venlafaxine be taken at the same time as cymbalta (duloxetine) ?

Don't: Usually these medications are not prescribed together. They are in the same class of medications (SNRI). If your doctor has prescribed both, consult with him/her about how and when to take these and the reason. ...Read more

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Is venlafaxine better the cymbalta (duloxetine) for nerve pain ?

Is venlafaxine better the cymbalta (duloxetine) for nerve pain ?

They are: Not the same but in the same category as SNRI'S (Seratonin Norepinephrine Reuptake Inhibitors). So bottom line, since everyone is different, you would have to just try one. I will say this: watch out for withdrawal symptoms or side effects such as headaches, sweats, shakes, and irritability. If that happens you have to wean off extremeve slowly always under psychiatric supervision. ...Read more

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Tapering effexor (venlafaxine) xr- dropped to 150mg from 225mg on saturday, and added 30mg duloxetine. Anxious, shaky hands, and nauseous. Is this withdrawal or serotonin syndrome? How long will this last?

Tapering effexor (venlafaxine) xr- dropped to 150mg from 225mg on saturday, and added 30mg duloxetine. Anxious, shaky hands, and nauseous. Is this withdrawal or serotonin syndrome? How long will this last?

Med interaction: Effexor (venlafaxine) + duloxetine interact to increase risk for serotonin syndrome. Call prescribing doctor for advice or go to urgent care for help if symptoms don't improve or get worse. See: http://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/basics/definition/CON-20028946 I hope this helps. ...Read more

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Effexor (Definition)

Venlafaxine is a non-tricyclic which is a kind of serotonin-norepinephrine reuptake inhibiting drug (atypical anti-psychotic ...Read more