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Doctor insights on: Cymbalta Versus Effexor

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Effexor (Definition)

Venlafaxine (effexor) is an snri (serotonin and norepinephrine reuptake inhibitor) that is used for the treatment of depression; depression & anxiety; generalized anxiety disorder; & social anxiety. Effexor xr is sometimes used for panic disorders. It can cause nausea, headaches, anxiety, insomnia, drowsiness. & hypertension. Seizures have been reported. Be careful not ...Read more


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How are cymbalta and Effexor XR different?

Different compounds: Cymbalta and Effexor xr are different chemical compounds which are both used to treat depression and anxiety disorders; however, they share a similar "mechanism of action", in that both are serotonin and norepinephrine reuptake inhibitors (snri's). Cymbalta is also used in the management of fibromyalgia and (in europe, at least) urinary incontinence. Their side-effect profiles are also different. ...Read more

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I've been taking cymbalta 120mg/day for years. It's now very expensive. Is generic Effexor an alternative especially for the chronic shoulder pain?

I've been taking cymbalta 120mg/day for years.  It's now very expensive.  Is generic Effexor an alternative especially for the chronic shoulder pain?

Effexor: Yes Effexor shares many of the same properties as Cymbalta and is much cheaper. Discuss with your doctor who will likely be willing to try it. You have to slowly go up icon the dosing, so don't give up too early if not helping on the starter dose. Your doctor can help you set up a dosing sequence tailor made for you. ...Read more

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I have never been able to achieve an orgasm, i was on Effexor and now am on cymbalta, they are used to treat my fibromyalgia please help me!

I have never been able to achieve an orgasm, i was on Effexor and now am on cymbalta, they are used to treat my fibromyalgia please help me!

If you were unable: To achieve orgasm prior to use of Cymbalta or Effexor - than this goes beyond medication side effect. However, sexual experience can be negatively impacted by depression, fatigue and chronic pain. May wish to explore this issue further with your physician. ...Read more

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Is it safe to be taking cymbalta, Effexor and Valium together?

Is it safe to be taking cymbalta, Effexor and Valium together?

Multiple Psych MEds: Unless there is a strong reason to, Effexor and Cymbalta work by the same mechanism, your risk for blood pressure will increase a lot valium is like xanax but much longer acting to calm anxiety, help with sleep and panic etc. ...Read more

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My son 18 years old his in Effexor XL not doing well can he take Cymbalta its ok for his age?

My son 18 years old his in Effexor XL not doing well can he take Cymbalta its ok for his age?

Depression/anxiety: Yes that's fine for his age, let his doctor tell you how to start it and get off the effexor. ...Read more

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Switching from Effexor to cymbalta reduced my drowsiness, after 2 month on cymbalta again i'm drowsy.Tapered dose from 60mg to 30mg last week.Regards?

Switching from Effexor to cymbalta reduced my drowsiness, after 2 month on cymbalta again i'm drowsy.Tapered dose from 60mg to 30mg last week.Regards?

Check MTHFR: Genotype 677 ; 1298. Almost 100% of people treated for depression for extended periods of time are positive for these genes. It is related to low folate ; B12 levels which causes fatigue.Getting treated can help all your meds work much better because your body will finally be able to make its own serotonin, nor-epi, ; dopamine.Tx is safer than placebo-15mg of l-methylfolate, p5p 50mg, 4mg b12. ...Read more

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Effexor is known to raise blood pressure...Cymbalta not quite so ..Is this accurate?

Effexor is known to raise blood pressure...Cymbalta not quite so ..Is this accurate?

Correct: While all serotonin-norepinephrine reuptake inhibitors (snris) can raise blood pressure, generally those with more activity on norepinephrine levels (effexor, pristiq, savella) tend to have more effect on blood pressure than cymbalta, which has a 1:1 effect on norepinephrine and serotonin. ...Read more

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Does Cymbalta cause weight gain. Also your thoughts on Effexor. Don't want to gain weight and am currently on Wellburin.tx?

Does Cymbalta cause weight gain.  Also your thoughts on Effexor.  Don't want to gain weight and am currently on Wellburin.tx?

Be careful!: Even non-pregnant people need to be very cautious combining Wellbutrin with either of those medications - seizure risk is increased as well as other risks. All anti-depressant seem to result in weight gain for some folk - even ones that cause loss in others. In your case - definitely work w/ your OBGYN to be safe. Try to find a diet plan that will be good for you, your baby and weight control. ...Read more

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It is said that cymbalta's serotonin to norephinephrine is 1:1..Does that make it an even ratio...And is it then stronger/weaker than effexor/pristiqe?

It is said that cymbalta's serotonin to norephinephrine is 1:1..Does that make it an even ratio...And is it then stronger/weaker than effexor/pristiqe?

Even: Cymbalta has a balanced/even effect on serotonin and norepinephrine, 1:1 ratio of blocking reuptake of both molecules. Technically, that would make it weaker than effexor, which has roughly 3:1 norepinephrine to serotonin reuptake inhibition . Clinically however, they are both beneficial for many similar diagnoses, it's just a matter of finding out which is better for each individual. Good luck! ...Read more

Cymbalta (Definition)

Cymbalta (duloxetine) is an "antidepressant" medication. However, it is an approved treatment for a variety of indications to include (unipolar) depression, anxiety, and chronic pain (related to diabetic neuropathy, musculoskeletal and/or fibromyalgia). Pharmacologically, it primarily enhances 2 different neurotransmitters (serotonin and norepinephrine). It can cause a ...Read more


Dr. Krishna Kumar
506 doctors shared insights

Venlafaxine (Definition)

It belong to classification of snri antidepressant also help anxiety start slow go slow its approved for depression and anxiety disorder there are some common side effects important never stop suddenly always taper slowly if you ever ...Read more