Doctor insights on:
Should I be worried about getting Parkinson's disease from 60 mg. Of cymbalta? I read where it increases increases serotonin but decreases dopamine.
No: It will not cause Parkinsonism, but can aggravate preexisting Parkinsonism. ...Read more
I am on cymbalta (duloxetine) for the rest if my life. Should I be worried about getting or tar dive dyskinesia or Parkinson's or motor control disorder?
My mom is 72 years old. Three years ago, she was diagnosed with dementia. She takes zoloft, cymbalta, (duloxetine) a cholesterol pill, nasonex, and aspirin. Does overmedication lead to parkinsonism symptoms?
Parkinsonism: Yes. There is evidence that certain chemicals and pesticides can cause parkinsonism. We are now experiencing an epidemic of parkinsonism but it is not clear why this is happening. ...Read more
Why do you wonder?:
Check out these links:
http://www. Lifenph. Com
http://www. Ninds. Nih. Gov/disorders/normal_pressure_hydrocephalus/normal_pressure_hydrocephalus. Htm
http://www. Nlm. Nih. Gov/medlineplus/ency/article/000752.htm
http://www. Webmd. Com/brain/normal-pressure-hydrocephalus ...Read more
In Parkinson's disease, does dopamine loss happen mainly in the striatum or does it occur in the s.Niagra too?
Parkinson: Basal ganglia, which includes both.Get a more detailed answer ›
Can you tell me in Parkinson's disease, does dopamine loss occur merely in the striatum or does it occur in the s.niagra too?
Pigmented nuclei: The dopamine loss involves predominantly the basal ganglia area, but also involves dorsal vagal nucleus, substantial nigra, and areas of any dopamine interaction within brain and brain stem. But, to be complete, Parkinson's is a multi-neurotransmitter degenerative deficiency syndrome with other neurotransmitter systems involved. ...Read more
Neuro is adding Lexapro 2 my meds, hope u can c my med list now! & on Cymbalta (duloxetine) but then quit Cymbalta (duloxetine) after 2wks. These 2 meds safe 2 take together?
Dose duration matter: Cross-tapering antidepressants is often done to prevent negative side effects from coming off a medicine. Even a medicine that isn't working well enough is often doing 'something' and patients may miss it when it's gone. Although Cymbalta (duloxetine) interacts with A LOT of drugs, Lexapro doesn't. Over a short period (2 weeks), at reasonable doses, there shouldn't be problem. ...Read more
Yes: Although the causes are multifactorial and sometimes poorly understood, there is a hereditary component. Keep in mind, that even though a parent may have it, it does not mean that it will be necessarily passed on. The tendency, however, may be there. ...Read more
Dose?: Depends on the medication but some parkinson medication required "drug holiday" to allow the drug to clear and be restarted, some medications work differently causing brekthrough symptoms. It could be that dosing needs adjusted as well. ...Read more
In theory, it should: Theoretically, Azilect (rasagiline) (an MAO-B inhibitor) should help with many of the symptoms of Parkinson's for a certain period of time. However, as with all treatments for this disease, they are notoriously unpredictable. I've attached an article which I hope might help. Good luck! Http://www. Reprintsdesk. Com/landing/hf. Aspx? H=523154&hr=716110317&a=1&u=0&r=826399194 ...Read more
Why can t healthy dopaminergic neurons be moved into the area of parkinson s affected neurons to treat parkinson s disease?
Not so simple: Most of the dopaminergic neurons end in the substantia nigra of the midbrain, originating in various deep brain structures. These nerves are already affected by the disease. Unaffected nerves of course still remain but remain connected to brainstem. So outside nerve cells (from another source like stem cells are needed) nerves don't like to be moved around anyway, because they often die. ...Read more
There is no cure for PD, and no treatment prevents the disease from progressing. However, treatments can usually ease symptoms. Consult your doctor.
http://patient. Info/health/parkinsons-disease-leaflet ...Read more
Numerous brain injuries cause disruptions in the fragile circuits that govern brain function. When injuries occur deep within the brain, they may affect a part of the brain that regulates movements.
The part of the brain most involved in suppressing Parkinsons movements is called the substantia nigra. Mr. Ali has had injuries that damaged this part of the brain, which leads to his tremor. ...Read more
Many types: There are many types of drugs that are used to treat the symptoms of parksinson's disease. The mainstay of treatment are the dopaminergic medications include Levodopa (in various combinations) and the Dopamine agonists (e.g., rasagiline, ropinirole, etc). Other medications such as anticholinergics are to treat other manifestations of the disease. See: www. Parkinsons. Org & www. Michaeljfox. Org. ...Read more
Yes, Absolutely!!: Stay physically, mentally & spiritually (if important to you) active, to keep yourself in best physical condition & spirits. See a movement didorder specialist or at least a good local neurologist for Dopamine medication treatment, advice, education & inspiration to fight your pd! Azilect is a great med to start with, then possibly a 24 hour lasting Dopamine agonist like Requip XL or Neupro (rotigotine) :). ...Read more
Hopefully will help: Are you really 33, as you would be quite young for parkinson's. Sinemet (carbidopa and levodopa) is the main "go to" drug, and could very will be required in higher doses if your problem is progressing. Usually works quite well with limited adverse effects. Discuss fully with your neurologist. ...Read more
Good Rx available!!: Dopamine meds are mainstay of treatment. Modern therapy recommends longer lasting, milder potency meds first: Azilect (mao-b selective inhibitor) & Dopamine agonists (requip xl/mirapex er/neupro). After they've been maximized & stronger meds are needed to adequately manage symptoms, then sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together) are begun. Tailor rx with side effects in mind for each person. ...Read more
Mostly not inherited: The vast majority of people with Parkinson's seem to get it sporadically, that is without any clear inheritance from family. That being said, we've found around 12 genetic variants that seem to greatly increase the risk of developing pd in some families. Some of them are recessive (rarely crops up), and some are dominant (50% chance of getting it from 1 affected parent). ...Read more
Parkinson Symptoms: Non-motor Symptoms occur 3-20 yrs before motor symptoms. They are REM Sleep Behavior Disorder, Constipation, Decrease or loss of smell, anxiety and depression. Motor symptoms occur when 67% of the neurons that produce dopamine in the Substantia Nigra. They are Rigidity, Slowness of movement +/- tremor. A soft voice, masked face, small handwriting & shoulder pain can also occur. ...Read more
Even DBS surgery!!: Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time). Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results. ...Read more
No good answer yet: It is believed that parkinson's disease like many other neurodegenerative diseases arise from a combination of factors including genetics and environmental influences. Sometimes there are medications that can cause a parkinsonian syndrome and rarely there are structural lesions such as strokes that can cause a similar clinical picture. Take care and well wishes. ...Read more
Unlikely unless: While there's a genetic component, it's unlikely that you currently have Parkinson's disease w/o knowing it unless you're ignoring resting tremor, difficulty getting moving, change in gait, change in handwriting, etc. Check out http://www. Mayoclinic. Org/diseases-conditions/parkinsons-disease/basics/definition/con-20028488 for more info. ...Read more
Parkinson's disease: Is the result of a deficiency of dopamine in a specific area in the brain. Medications that replace the dopamine, mimic the action of dopamine, or reduce the breakdown of dopamine in the brain are used to treat the symptoms. Medication regimens must be adjusted individually. Deep brain stimulation may be helpful when medications do not adequately control symptoms. ...Read more