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Doctor insights on: Cyclobenzaprine Drug Interactions

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Dr. Jan Lei Iwata
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Drug Interaction (Definition)

When the combination of two agents cause an effect, intended or unintended, that would not have otherwise ...Read more


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Mixing drugs perigesic and cyclobenzaprine should a person take the two drugs together?

Should be safe: I assume you mean pyrigesic or Acetaminophen (tylenol). This is a non-narcotic pain killer, and it should have no difficulty being combined with the muscle relaxant cyclobenzaprine (flexeril). Just stay under 4000mg, and ideally 3000mg, of pyrigesic per day for the health of your liver. ...Read more

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Is flexeril (cyclobenzaprine hcl) a drug that can get you kicked out of military service?

Is flexeril (cyclobenzaprine hcl) a drug that can get you kicked out of military service?

No, but...: It will ground you if you have airborne or diving status, and your profile will/should indicate you are on muscle relaxants which may impact safety and keep you from doing your MOS. You may be stuck in the motor pool for a while until you are considered safe by your treating military doctor. Being on a limiting T3 (liothyronine) profile long enough - regardless of reason - will send you straight to the MEB. ...Read more

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Can I take Cyclobenzaprine and Ativan (lorazepam)? The pharmacist didn't see an interaction but it doesn't seem ok to do?

Can I take Cyclobenzaprine and Ativan (lorazepam)? The pharmacist didn't see an interaction but it doesn't seem ok to do?

Safe: If you have a normal metabolism this should be a safe combination. I have several patients on Cyclobenzaprine and Benzodiazepines who are doing well. . ...Read more

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Is there any interaction between cyclobenzaprine and mitrazapine or amitryptaline ? Can i take it for my back pain along with these meds ?

Is there any interaction between cyclobenzaprine and mitrazapine or amitryptaline ? Can i take it for my back pain along with these meds ?

Caution: Depending on dosage and frequency of use, serotonin syndrome is possible with this combination. Also, these medications are mutually sedating. Discuss this with your physician and pharmacist, please. ...Read more

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I had back pain so bad today I couldn't stand. I took 1 10mg(my dads)cyclobenzaprine tablet Will this cause me to fail a military drug test in 10 days?

I had back pain so bad today I couldn't stand. I took 1 10mg(my dads)cyclobenzaprine tablet Will this cause me to fail a military drug test in 10 days?

Cyclobenzaprine: http://www.rxlist.com/flexeril-drug/clinical-pharmacology.htm Half life is about 18 hours (up to 37 hrs) so by 10 days , you should be through 7-13 half lives so the amount in your blood should be negligible. So would not worry. Do not take any more unless you have a prescription( if you have a valid prescription, then it usually does not cause problems with drug testing). f/u/ w/ doc. ...Read more

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Cyclobenzaprine HCl will it show up in drug testing?

As a tricyclic: Cyclobenzaprine is not chemically similar to benzodiazepines, which include drugs such as xanax, (alprazolam) ativan, valium, and klonopin. There should be no cross reactivity between cyclobenzaprine and benzodiazepines on drug testing. Cyclobenzaprine is chemically similar to tricyclic antidepressants, such as Elavil (amitriptyline). Some panels for substances of abuse do include tests for tricyclics. ...Read more

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I have not took flexeril (cyclobenzaprine hcl) in four days will it show up in a drug test?

I have not took flexeril (cyclobenzaprine hcl) in four days will it show up in a drug test?

Possibly: The rate of drug elimination from the body is called the half life; it is the time for half of the dosage to be eliminated. After two half lives, only 1/4 of the amount will be present. The half life of cyclobenzaprine ranges fro 8 to 37 hours, and is affected by many other medications however, cyclobenzaprine is not a drug of common abuse, and would not likely show up n a drug abuse screen. ...Read more

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Hello, i take weekly oral drug tests and they came up clean for years until i was prescribed flexeril (cyclobenzaprine hcl) and now my benzos come back dirty. Why is this?

Hello, i take weekly oral drug tests and they came up clean for years until i was prescribed flexeril (cyclobenzaprine hcl) and now my benzos come back dirty. Why is this?

Not Soma (carisoprodol)?: Soma metabolite can trigger bdzp screen, possible Flexeril (cyclobenzaprine hcl) metabolite as well. Need to ask for information on the test used, and method of confirmation / follow-up testing (first usually qualitative, confirmatory quantitative). If no bdzp ingestion, quantitative testing should report negative. ...Read more

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Will flexeril (cyclobenzaprine hcl) give you a false positive on a drug test? I have recently been prescribed flexeril (cyclobenzaprine hcl) and took a drug test and i failed it. I do not do drugs and it showed up as THC why is this

Not likely: Most drug tests use a first test, TLC or thin layer chromatography, as an initial screen. This test is prone to cross-reaction or "false positive" results for some substances. Usually if the TLC is positive, a second test, gcms or gas chromatography mass spectroscopy is used to confirm. This test is much more specific for specific molecules and not likely to yield false positive results. ...Read more

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Is there a dangerous interaction between cyclobenzaprine and the herbal supplement rhodiola? I've read that this herb acts as an MAOI.

Is there a dangerous interaction between cyclobenzaprine and the herbal supplement rhodiola? I've read that this herb acts as an MAOI.

Well possible: The herbal medications can cause serious medical issues. You need to discuss the use of the herbal medications with your doctor. Do not go mixing prescribed medications with anything unless fully discussed with your doctor ...Read more

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Can flexeril (cyclobenzaprine hcl) show up on a 9 panel hair follicle drug screen?

Can flexeril (cyclobenzaprine hcl) show up on a 9 panel hair follicle drug screen?

Only if they : Are specifically looking for it which is doubtful. It is also not illegal if you have a prescription for it. It is not a controlled substance. Best wishes. ...Read more

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Can cyclobenzaprine get you high?

Can cyclobenzaprine get you high?

Yes: It has been known to change you mentation and can make you very sleepy or drowsy as well Be careful with this medication ...Read more

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Can cyclobenzaprine get you high?

Can cyclobenzaprine get you high?

Cyclobenzaprine: Cyclobenzaprine may numb you brain, temporally feeling relax. It has obvious side effects if you use without medical indication. High itself is a abnormal status. Please do not hurt yourself, family and society to seek high. ...Read more