Doctor insights on:
Cyclic Adenosine Monophosphate
Mitochondria: Rare genetic mitochondrial diseases can result in defects in ATP synthesis, resulting in muscle weakness and other symptoms. Nutritional supplements have been tried and some people think they help but there is very little evidence for this treatment. A good source of info is at http://www.mda.org/disease/mitochondrial-myopathies/causes-inheritance ...Read more
Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?
Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more
What things, in the body, regulate glutamic acid? Glutamic acid decarboxylase? Glutamate receptors (nmda, ampa...Etc.)? What else is involved?
It's complicated...: There are some very exciting discoveries on the metabolism of glutamate... There are multiple pathways impacting on things such as gaba neurotransmitter, nitrogen clearance from the liver portal, etc... These pathways play vital roles in survival! please read this.... And email me your questions if you'd like! http://voh.Chem.Ucla.Edu/vohtar/spring04/classes/153ch/pdf/kelly%20and%20stanley.Pdf. ...Read more
Hydroxyprogesterone hexanoate is androgen precursor with elimination half-life 7.8 d,for an injection 5ml of 250 mg/mL what is such androgenic effect?
A Hairy Proposition: In women, excess amounts of androgens can cause such "virilizing" effects as acne, hirsutism (excess hair growth in "inappropriate" places, like the chin or upper lip) and thinning hair. Long-time use is associated with serious health consequences, such as insulin resistance and diabetes, high cholesterol, high blood pressure and heart disease. It all sounds like lots of fun, doesn't it? ...Read more
Which glutamate receptor(s) are affected negatively by monosodium glutamate: ampa, nmda, and/or kainate?
Why is ATP the preferred energy currency , not GTP (guanosine triphosphate), CTP or TTP? Please answer me
Do not know: There are many quirks of life on earth that cannot be explained. Why are amino acids of L form and sugars of D form only? Why are neural circuits crossed so that left side of the brain controls the right side of the body? Why don't we live longer? Why don't we have eyes on the back of the head to be able to have 360 degree vision. Ask your God! ...Read more
Hydroxyprogesterone hexanoate is made from 16-dehydropregnenolone acetate,does it have androgenic activity?
Why does acetylcholine, an inhibitory neurotransmitter, cause the adrenal glands to release stimulatory hormones?
Not correct: Hi. Acetyl choline (ACh) is not an inhibitory neurotransmitter. The sympathetic nervous system uses ACh as the neurotransmitter in the sympathetic ganglia (the 1st synapse outside the CNS). Usually that's from one neuron to another, but in the adrenal medulla, the cells are really the second neuron, but they release their contents (catecholamines) into the blood, not onto an organ (like the heart) ...Read moreSee 1 more doctor answer
Not definite: no specific meds for glutamate dysfunction, anything available has a lot of side effects. ...Read more
Can psilocybin or lysergic acid diethylamide induce serotonin syndrome when combined with sertraline?
Russian Roulette.: There have been no actual studies done on this for obvious reasons. I can say a couple of things that may be useful though. Given your medical history, it would be very ill advised to use either LSD or Psilocybin containing substances. Both are known to precipitate severe anxiety in those even without a history of panic disorder. They are illegal, and street drugs are often spiked with other drugs. ...Read more
Not that I'm ....: Aware of. Ada deficiency is one of the causes of severe combined immunodeficiency (aka, scid). Paraganglioma has been specifically correlated with mutations in succinate dehydrogenase (sdh) mutations, and likely reflects a link between cell growth/fate specification, epigenetic control of gene expression and metabolism. ...Read more
What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?
None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read moreSee 1 more doctor answer