Doctor insights on:
Nothing: Why would you use this???? It is probably low potency. B12 is cheap. Why inject it? Most patients today are given a daily 1000mcg "nugget" to swallow. It is cheap and completely free of side effects. What is the indication? This is a long-term therapy, not an occasional treatment. ...Read more
B12 NOT toxic: Cobalamin (or vitamin b12), is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the 8 b-vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting dna synthesis and regulation, but also fatty acid synthesis and energy. Vitamin B12 has extremely low toxicity. ...Read more
Similar: The methyl form is biologically active, and will directly interact with receptors, but in most cases, the body will convert the other form readily, so in the end, there is equivalency. ...Read more
Methylcobalamin: Methylcobalamin is by far the best form of vitamin b12. This is the co-enzymated active form that our bodies use. When we take Cyanocobalamin our bodies must first convert it into methylcobalamin, so it is better to take the active form and save your body the trouble of making this conversion. See http://www. Naturalnews. Com/027045_vitamin_b12_cyanocobalamin_methylcobalamin. Html. ...Read more
I have an unopened vial of cyanocobalamin that is a couple years expired. What would happen if I used it?
DO NOT USE IT: Never use expired medication for any purpose, especially injectable medications. ...Read more
I have been prescribed Methylcobalmin 1000mcg/ml injection but I am able to get either cyanocobalamin or mecocobalamin. Could I use either of the two?
Yes, probably: Cyanocobalamin is an artificial B12 which must be activated in the liver. Methylcobalamin or Mecobalamin is a biologically active form. Your doctor may have a reason for preferring the active form. BTW, Mecobalamin is fully absorbed through the mucous membranes of the mouth, but cyanocobalamin is not and must be absorbed through the gut (unless injected). ...Read more
Different forms B-12: They are different forms of vitamin b-12. ...Read more
No, however...: A famous saying is "the poison is in the dose." Cyanide naturally occurs in trace amounts in many foods including almonds, soy and spinach. The amount of cyanide when we metabolize cyanocobalamin is tiny and it's detoxified by our body. However, we need to convert it to the active form, methylcobalamin, so better to take that form so we don't have to convert it and not waste our detox resources. ...Read more
Cyano c. is inactive form.
Hydroxy c. is natural form.
Methyl c. is an active form.
Adenosyl c. is also an active form of c. but unlike the others, it is not available by injection. ...Read more
Methylcobalamin: Methylcobalamin is by far the best form of vitamin b12. This is the co-enzymated active form that our bodies use. When we take Cyanocobalamin or hydroxycobalamin our bodies must first convert these into methylcobalamin, so it is better to take the active form and save your body the trouble of making this conversion. See my comment for a link to more info:. ...Read more
Why do that?: If your physician recommended it to be done this way I would ask them for their reasoning. Otherwise, I don't see the logic in doing 2 separate injections of cobalamin as you suggest. I would choose one formulation and provide my patient with a single injection with the proper amount I wanted them to receive and be done. ...Read more
B12 as methylcobalamin or B12 as cyanocobalamin - which one is safer/better and in what form : pills or sublingual?
No difference: 2 mg oral is supposed to be as good as sub lingual. I usually recommend 1.7 mg SL liquid every week for 2 months then once every 2 weeks thereafter. I recommend maintaining a level of 550 at all times. One should also check folate (folic acid) level and make sure that is OK. If anemic and you are replacing B12 its wise to check for low potassium as correction of the anemia can deplete K+ stores. ...Read more
Can cyanocobalamin be lethal or harmful to the human body if it cannot process the cyanide component? If yes, should one avoid cyanocobalamin?
Cyanocobalamin has trace amounts of cyanide; the usual dose is 1 mg (one thousandth of a gram) or less; only some of that is the cyanide, which is readily detoxed by several mechanisms so everyone can likely clear it. There is cyanide in almonds, bamboo shoots, cassava and other foods.
I advise taking methylcobalamin, the active form we convert the cyano form to, as some have trouble converting it. ...Read more
Do all fortified foods contain cyanocobalamin or do some contain methyl or hydroxo, and which natural sources of b12, are the most bioavailable?
No way of knowing if "all" have the cyano form but I believe virtually all have that form as it is the least expensive and most widely available. But methylcobalamin is the optimal form for supplementation- see http://tinyurl. Com/h7scsna
Some foods contain higher concentrations of B12 but the form found in food is hydoxycobalamin so all equally bioavailable. See http://tinyurl. Com/j7npwg3 ...Read more
I take 5000mcg cyanocobalamin daily and am noticing symptoms coming back. Could it be from the sublingual tabs? I was on shots but had bad reactions.
Explanation: To figure out what is going on need to know : what symptoms are coming back, what shot do you have, and how often. Please describe it or go to your doctor to discuss your condition. ...Read more
I just im'd 1 mg cyanocobalamin (1ml fluid, 1 insulin syringe full) I want to know is this the normal weekly dose because I'm not clear about instruct?
Get Instructions: If you are not clear on instructions call your doc for clarification. 1 mg/week is a dosage that is commonly used, but your instructions coule easily be for mor or less. Best to get the answer from the doc who prescribed it. ...Read more
Nominally B12Allergy: Which is essentially not c/w staying alive. Cyanocobalamin is the technical name for B12. Like all vitamins, it is a single molecule used as an tool/aid for specific enzymatic reactions & so common in stuff from nature which humans have long eaten that humans have not maintained every gene to make all protein enzymes to make out of other molecules; typically missing only a single step of many. ...Read more
Cynacolabamin: It is methylcobalalmine gets absorped much faster and will be my choice. ...Read more
Avoid cyanocobalamin: Cyanocobalamin is a cheap synthetic form of B12 that does release cyanide when metabolized by our bodies. The amount of cyanide is small and our bodies can detoxify it, but our bodies have to work to convert Cyanocobalamin to methylcobalamin, the active form. It is far better to take the methylcobalamin form. See http://www. Naturalnews. Com/027045_vitamin_b12_cyanocobalamin_methylcobalamin. Html. ...Read more
What are the differences between vitamin B12 methylcobalamin, cyanocobalamin, and methylcyanocobalamin?
The body needs to methylate B-12 so it becomes biologically active to engage in chemical reactions, so the methylated forms are in that category, and the other would need chemical transformation to be active.
Lately, there seem to be some concerns regarding safety and efficacy of the cyanocobalamin, but not a proven fact. ...Read more
Does being a recreational endurance athlete have an impact on the dose of cyanocobalamin I should take monthly (have b12 deficiency).
You don't say if you: Are B12 deficient due to pernicious anemia, and consequently, take B12 by injection in high oral supplement doses. The ability, or lack of ability, to absorb B12 in the stomach is the most important determinant of dose. Usual supplement dosage is 1-2 mg/day. I could find no evidence that this needs to be increased or modified in the circumstance of endurance training and competition. Monitor level ...Read more
I read somewhere : B12 is stored as cyanocobalamin in our liver. If the above read is true, then why are we asked to take methylcobalamin form of b12?
Methylated B12: Is more bio-available, easier to absorb, than B 12. ...Read more
Not necessarily: Why do you wish to take a multivitamin, as recent studies suggest people have worse outcomes when they do take vitamins in that form. Also, many of the standard multivitamins do not dissolve in the gut, so not absorbed. Methylcobalamin is the biologically active form, and is present in medical foods, prescription items, but may be available in health food stores. ...Read more
Please tell me if there are any cereals or other B12 fortified vegan foods using hydroxocobalamin (not cyanocobalamin)?
Probably not but...:
As far as I know, all foods fortified with B12 are fortified with the cyanocobalamin form, as it is the least expensive. It is hard to know for sure, as the labels always just say B12 and don't specify the type. But if anyone is going to the extra expense of fortifying with hydroxocobalamin they are not telling us!
I advise vegans supplement with hyroxocobalamin or methylcobalamin. See comment: ...Read more
What is the best form of taking B12 supplement cyanocobalamin or methylcobalamin that you recommend to your patients and why. Thanks.
See below: Best efficacy and assurance of bodily incorporation occurs when injected once monthly. Some pts do well with sublingual prep, and some even absorb oral meds. Would urge you make certain that you do indeed suffer a vitamin b-12 deficiency prior to getting an aggressive solution. ...Read more
I'm a little concerned; I was given im cyanocobalamin and am supposed to inject 1ml per week. I already did that, but my question is thus; where does the fluid go if not into my veins? I'm new to this
From muscle to blood: When you inject i'm, the small blood vessels (capillaries) absorb mosr of it and send it off to circulate through your whole body, where it eventually gets distributed to your cells. ...Read more
Is it okay to take an inj for intramuscular use and inject it into subcutaneous fat? Pyridoxine (b6) and cyanocobalamin (b12) specifically.
No: Medications are designed and formulated specifically for intermuscular sucky tennis injection occasionally they can be given either way get specific advice from your doctor on this ...Read more
No: Cyanocobalamin is usually given at a dose of 1000 mcg/ml. The amount of cyanide in that small a dose is 20mcg. The lethal dose of cyanide for an140# person is 3, 1, 750 mcg. So it would theoretically take 1580 doses of B12 all at once to create enough cyanide to be lethal - interestingly, we consume more cyanide eating fruits and veggies than from a B12 shot! So don't worry about the cyanide in it! ...Read more
Diagnosed with autoimmune pernicious anemia 5 years ago. Levels still low or at times borderline despite monthly injections of cyanocobalamin.
What's wrong?: If the level of B12 is not enough you may need a larger dose. If you mean you still have a mild or borderline anemia that can be OK. There is no reason to make you better than normal (borderline is still normal). I see you have a low ferritin and a high iron saturation. Talk with your doc about why those numbers are what they are. You may have another source of anemia. ...Read more
No intrinsic factor: B12 in the diet usually binds to intrinsic factor in the stomach and then gets absorbed by the small bowel. In pernicious anemia, there is low or no intrinsic factor being made by the stomach cells. As a result, there is gradual deficit of B12 stores and eventaully as all the B12 is gone the new red blood cell production is affected. ...Read more
I receive 1000 mcg cyanocobalamin since 10/12. B 12 level to begin with 169. Beginning to have numbness in hands and feet again. Why?
Not sure.: You will need some lab testing to make sure we aren't missing anything. See doc. ...Read more
I'm 18 y and I have hereditary spherocytosis, I want to know if taking high doses of (folate (folic acid) as metafolin) can help me? And cyanocobalamin can help too?
Yes: Yes, absolutely, take folic acid, vitamin B12 supplement. In addition, you may want to ask you md to check your iron level and if your iron is low- you should also take some iron supplement. With hs- you will have chronic hemolysis - rbc destruction -thus your body needs what ever it takes to hep produce new red blood cell to compensate with the hemolysis. Also you are at risk to have gallstones. ...Read more
B12: B12 principally derives from animal sources and eggs. Dairy has little. Select soy can provide some. More vegan foods are being supplemented with B12, as B12 defici, ency is common among vegans. See www. Vegetarian. Org. Uk/factsheets/b12factsheet. Html ...Read more
Virtually nontoxic: At any dose. I do not believe that you will find very much written on the toxic effects of B12 although I have had a couple of patients who took something on the order of 10x what I had prescribed them was already in the 10, 000IU range so they were taking about 100, 000IU daily for several weeks and the patient developed diarrhea. When he stopped that resident, within several days diarrhea stopped ...Read more
Possible causes: You could have a low b-12 if you are vegetarian, have been for several years and don't take supplemental b-12. It could be low if you don't make intrinsic factor. This is made in the stomach and is needed to absorb b-12. Lack of intrinsic factor is usually an autoimmune disorder. You could have low b-12 due to taking proton pump inhibitors for a long time as stomach acid is needed as well. ...Read more
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