Doctor insights on:
Cutaneous T Cell Lymphoma In Children
Can 2 biopsies done at same time rule out cutaneous t-cell lymphoma completely? If symptoms point to ctcl but biopsy was neg when should we re-biopsy?
Not Completely: The average number of biopsies to completely diagnose CTCL is about 6. That said, if the type of CTCL is the common type, mycosis fungoides(MF), and not mimics of MF, then 1 or 2 biopsies could be diagnostic especially if typical patches, plaques of CTCL. If the latter, ancillary tests including molecular clonality T cell test are crucial for diagnosis excluding mimics. Rebiopsy in about 3 mos. ...Read more
Skin is the largest and one of most complex organs of body. 3 layers: epidermis (outer), dermis (main part) and subcutaneous layers covers entire body, contains many specialized cells, maintains body temp, gathers sensory info from the outer world, has extremely important immune functions. It can give crucial clues as to what is internal. Dermatology and plastic surgery are ...Read more
Type of NHL: Cutaneous t cell lymphoma (ctcl) is a type of non-hodgkin's lymphoma(nhl), which is a type of cancer of the immune system. Unlike most nhl (which are generally b-cell related), ctcl is caused by a mutation of t cells. The malignant t cells in the body initially migrate to the skin, causing various lesions to appear- reference wikipedia and cancer. Gov. Best wishes. ...Read more
Multiple fashions: It varies by stage (spread). It can be treated via chemotherapy or radiation therapy. Some uses total skin radiation in some cases. In my practice, even when widespread and felt to be "incurable" focal radiation a few worst problemsites (say 2 or 3) can make it a long term issue when other methods of treatment fail. It is best to find a team of local md's who treat it often. ...Read more
Itchy skin: Pruritus /itchy skin would be the most common symptoms. Skin manifestation can vary from redness, dryness, lumps, etc. ...Read more
Not exactly...: Cutaneous t cell lymphoma (ctcl) is a disorder of a type of immune cell, the t cell. Hodgkin's disease is a cancer of b cells, another type of immune cell. Thus, ctcl is technically a non-hodgkin's lymphoma. However, people typically use 'non-hodgkin's lymphoma' to describe other types of b cell cancers that do not fit the characteristics of hodgkin's disease. Talk with your doctor for more info. ...Read more
Upper arms feel warm to touch, no allergies, past 4 days. What can cause this? Also, have been diagnosed with cutaneous T cell lymphoma.
Uncertain but need e: You need to see your oncologist to be certain there is no relationship.As you are immunodeficient -we are concerned about infection. ...Read more
Many types : There are many types of t cell lymphoma. Some types are very slow growing, treatable but not curable. Patients can live for decades. Other types are much more aggressive. Some are highly treatable and even can be cured while others are quite difficult to get into remission. ...Read more
The prognosis for t-cell non-hodgkin's lymphoma (nhl) vs. B-cell nhl depends on multiple factors, but in general t-cell nhl has a worse prognosis.
One reason is that b-cell, cd20+ nhl can be treated with the anti-cd20 monoclonal antibody Rituximab in addition to chemotherapy. We currently don't have such an effective, low toxicity antibody (biologic treatment) for t-cell nhl. ...Read more
Not really: Non-hodgkin's lymphomas are a very large group of diseases. Lymph cell can be called t cells or b cells based on surface proteins. T cell lymphomas are just one group of non-hodgkins lymphomas. There are also several types of those tcell lymphomas. ...Read more
A Rare Lymphoma: Hstcl is a rare cancer of the white blood cells. It usually affects young men with a history of immunosuppression for other diseases like inflammatory bowel disease (uc and/or crohn's) or after an organ transplant. The bad cells usually grow in the liver, spleen and bone marrow. It is treated with chemotherapy and possibly a bone marrow transplant. It unfortunately can be difficult to cure. ...Read more
What is the relationship of hepatosplenic t-cell lymphoma and low lymphocyte levels in the blood?
Retained in spleen: The spleen can be quite large and contain really high numbers of malignant lymphocytes. In these cases, both normal and malignant lymphocytes can be low in the peripheral blood. ...Read more
NK/T cell NHL: The treatment is largely determined by the extent of disease. Patients with localized stage, therapy would be combined radiation and chemotherapy. Patients with disseminated lymphoma, combination chemo would be recommended. For most patients who achieve a partial response after induction therapy, a bone marrow transplant as consolidation would be recommended. Discuss with your oncologist. ...Read more
Skin biopsy for some reason tested cd3 but was neg does that ensure no t cell lymphoma or it could still be developing?
Yiour doctor/oncolog: Only you're treating doctor can help explain what is going on. Please ask him/her to explain and get your answers from the person putting you thru the biopsies etc. It does not sound anything meaningful to me. ...Read more
Peripheral t-cell lymphoma cure: chop induction+ifosfamide/mtx + autologous transplant or romidepsim+brenduximab?
Complex problem: Cannot comment with 2 lines of information. Need the entire clinical context. If you seek more detailed information get a formal second opinion. ...Read more
Have itchy skin. 2 biopsies with lymphocyte infiltrate no T cell lymphoma. Ana was 640. Could it be autoamune. Have Hypothyroid.
It could be: If your hypothyroidism is related to an autoimmune disorder, then your skin problem may be as well — guilty by association. Make sure that you have not become allergic to one of the medications you have been taking. There are several options on treatment and I suggest that you consult a dermatologist, a 2nd opinion if needed. ...Read more
Is angioimmunoblastic t-cell lymphoma still treatable if in the marrow, anemia, low platelets, swelling?
T cell lymphoma: It is treatable but need careful supervision under the oncologist as chemo can be detrimental with low blood counts but sometimes that is the only way marrow can be cleared of lymphoma so lot of thinking needs to be done in selecting appropriate chemo for such patients. ...Read more
I had t-cell lymphoma 3 times about 10 to 7 years ago, then breast cancer, did chemo and radi. And now, I have cracks in teeth is this normal?
Long term effects: Yes chemotherapy & radiotherapy will cause short term and long term damage to teeth along with gums. Yours could be long ted effects, causing cracks including loss of enamel. Good you won the battle 4 times, think it as battle scars, visit your dentist to save them. Good luck. ...Read more
Severe depression. What can I do? I just want to feel good again.(inside that is). I suffer chronic back pain from inneffective surgeries and have t-cell lymphoma. I have tried antidepressants(zoloft, paxil, Lexapro and pristiq). None of these have helped. Can
A : A combination of cognitive behavioral therapy and anti depressants is an effective treatment strategy. There are other anti depressants with a different mechanism of action that could be tried- eg: tricyclic anti depressants (nortriptyline), mirtazapine, MAO inhibitors. The treatment could also be augmented with medications in the class of Abilify (aripiprazole), seroquel etc. If nothing else works, electroconvulsive therapy is a safe and effective treatment option. Please talk to your psychiatrist and hope you get well soon. ...Read more
My grandson has anaplastic t-cell lymphoma. But it is low level lymphoma located on his left arm. What treatment would be best?
See a Ped Onc: Anaplastic large t-cell lymphomas (alcl) in kids usually have spread around the body by the time they are diagnosed. Very rarely they can remain localized to only one spot in the skin. Because of the rarity of this diagnosis the best treatment is not known, but good results have been reported with chemo, surgery and even radiation. A qualified pediatric oncologist can help find the best course. ...Read more
Cure is possible...: Cure is possible but depends on many individual patient factors. ...Read more
I have been sick for 2 years. At first I was diagnoses with tcell lymphoma. Trip to the mayo clinic ruled that out but still have abnormal t cell.?
Inflammatory?: Lymphocytes (t cell, b cell) can be "abnormal" but not cancerous such as inflammatory (viral) or autoimmune conditions. That might relate to 2 years of being sick. In that case the underlying condition (often hard to pinpoint) should be treated. The lymphoma (& other specialty) mds at mayo are exceptional. If you are in nc, there are other great institutions close by (eg, unc, etc) to investigate. ...Read more
Start with this link: http://www.cancerresearchuk.org/cancer-help/about-cancer/cancer-questions/childhood-non-hodgkins-lymphomaGet a more detailed answer ›
What is the reason for a CD4 / cd30 dual positive cell count in a cutaneous lymphoma panel? What does 53% & 2400 absolute count of these cells signal?
Biomarkers in blood: If your blood had a flow cytometry test showing expression of both markers, CD4 and CD30, and you have a lump or lymphadenopathy, then the hemeonc is looking for involvement of blood with T cell lymphomas that contain both markers. Transformed Mycosis Fungoides, spread of cutaneous anaplastic lymphoma which are often CD4+CD30+, or systemic ALCL going to blood could be reasons. Ask hemeonc about above ...Read more
What's the signifigance of finding 53% of peripheral blood cd4+ / cd30+ dual positive cells in a cutaneous lymphoma panel? Is this a sign of ALCL?
Could be call MD Onc: The most common Cutaneous T cell lymphoma is mycosis fungoides, which are CD4+ but lacks CD30 early on. Once progressed, the CD4 may acquire CD30, and hence transform to a mimic of anaplastic large CD30 + lymphoma. That said, so is coexpression of 53% in blood is unusual for cutaneous CD30 lymphomas, which are CD4+CD30+ yet mostly confined in skin. Systemic forms may show in blood. Call HemeOnc MD ...Read more
Panicking skin biopsy cd3 failed to reveal significant t cell dyscrasia. Do I have the start of lymphoma?
Can you clarify?: You list varying ANA results, one set of low compliment results, fatty liver, hysteroscopy and biopsy negative for cancer, and a skin biopsy that some pathologist stained up with cd3 for some reason and didn't find lymphoma. Lymphoma announces itself as an obvious mass or obvious symptoms. Why in the world are you panicking? Is this a communication failure with your physician? ...Read more
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