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Doctor insights on: Cutaneous Mastocytosis

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What is cutaneous mastocytosis?

What is cutaneous mastocytosis?

Mastocytosis: Mastocytosis is as skin disease where mast cells (a type of white blood cell containing histamine) accumulate in the skin--can be isolated or solitary or can be diffuse with multiple lesions. Needs to be seen by dermatologist. ...Read more

Dr. Brant Ward
43 doctors shared insights

Mastocytosis (Definition)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine ...Read more


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I have been diagnosed with cutaneous mastocytosis. Can pain in the abdomen and bleeding between periods be caused by this too ?

Yes: If your Drs are smart enough to diagnose urticaria pigmentosa, or cutaneous mastocytosis, they can guide you through all the associated symptoms. They can also [bone marrow?] check for systemic mastocytosis. Your Drs should be able to answer all your questions and evaluate all your symptoms. ...Read more

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How can you tell if mastocytosis is systemic or just cutaneous?

How can you tell if mastocytosis is systemic or just cutaneous?

Evaluation: Systemic involvement will be more suspicious when the serum tryptase level is significantly elevated and you also have other generalized symptoms like GI problems or abnormality in the blood counts for instance. A biopsy of the suspected involved organ like biopsy of the bowel, or bone marrow biopsy will tell you definitively whether it is systemic or not. Discuss with your doctor. ...Read more

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What does mastocytosis mean?

What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Anyone diagnosed mastocytosis? How?

Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more

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What is mastocytosis and is it serious?

Mastocytosis: Is an excess number of mast cells. It is usually not an aggressive process. ...Read more

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What is the definition or description of: mastocytosis?

What is the definition or description of: mastocytosis?

Too many mast cells: Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells. ...Read more

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What is a cure for mastocytosis?

What is a cure for mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Anyone know treatment of mastocytosis?

Anyone know treatment of mastocytosis?

Topical steriods: If your mastocytosis is symptomatic, then prescription strength topical steriods are beneficial. ...Read more

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Survival rate with systemic mastocytosis?

Survival rate with systemic mastocytosis?

Usually normal: Most people with a systemic mastocytosis have the 'indolent' variey, in which case their life span is the same as anyone else's (provided they get appropriate treatment for any anaphylactic reactions). There are very rare cases that we call 'aggressive.' in this case, it may shorten expected lifespan depending on just how 'aggressive' it is, but some of these may be amenable to treatment. ...Read more

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Cutaneous (Definition)

Skin is the largest and one of most complex organs of body. 3 layers: epidermis (outer), dermis (main part) and subcutaneous layers covers entire body, contains many specialized cells, maintains body temp, gathers sensory info from the outer world, has extremely important immune functions. It can give crucial clues as to what is internal. Dermatology and plastic surgery are ...Read more