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Doctor insights on: Cushing's Disease Vs Cushing's Syndrome

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Do I have cushing syndrome or disease---what is the difference?

Do I have cushing syndrome or disease---what is the difference?

Cushing's: Cushing's syndrome is any conditions that cause the adrenal gland to produce too much cortisol. Cushing's disease is a adenoma (tumor) in the pituitary that produces a hormone called acth which causes the adrenal gland to produce too much cortisol. ...Read more

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Difference between cushing disease and syndrome ?

Difference between cushing disease and syndrome ?

Disease vs. syndrome: Hi. Cushing's disease is specifically hypercortisolism due to an ACTH-secreting pituitary adenoma. Cushing's syndrome is simply the clinical manifestations of hypercortisolism, and (once you know it's not pituitary) can be due to adrenal tumors (benign or malignant), exogenous glucocorticoid therapy, or a paraneoplastic syndrome (cancers that secrete ACTH or CRH). ...Read more

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What is the cause of the hyperpigmentation in people with cushing syndrome and addison's disease?

What is the cause of the hyperpigmentation in people with cushing syndrome and addison's disease?

Pituitary hormone: These people have increased secretion of crh (corticotropin releasing hormone & acth (adrenocorticotropic hormone, also called corticotropin) from the pituitary gland. The cells that secrete acth also secrete melanocyt stimulating hormone (msh). Msh stimulates skin and mucus cells to secrete melanin (dark bronze pigment) which leads to the hyperpigmentation. Thats the full story! ...Read more

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What is Cushing syndrome?

Cushing syndrome: read this: http://en.wikipedia.org/wiki/Cushing%27s_syndrome

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What are signs of cushing syndrome?

There are many: Many patients have multiple signs & symptoms, including (but not limited to): facial plethora, violet colored striae ("stretch marks"), high blood pressure, glucose intolerance, weight gain, facial roundness, weakness, and "central" obesity (i.e., in the truncal area). Acne, decreased libido, & menstrual irregularities are common. Detailed exam & testing are necessary to rule out related conditio. ...Read more

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What is cushing disease ?

Disease vrs Syndrome: Cushing disease, which is hypercortisolism caused by an acth-secreting pituitary adenoma, is the most common cause of cushing syndrome, and is responsible for 60% to 70% of cases. Cushing syndrome is mainly caused by other sources of corticosteroids like the medicines dr prescribe to treat many conditions ( prednisone, medrol, (methylprednisolone) solumedrol, (methylprednisolone) deposed rol, etc) commonly in copd, asthma, allergies. ...Read more

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What is cushing syndrome and its cure?

Pituitary tumor: A pituitary tumor causes classic cushings syndrome. The tumor releases acth which stimulates the adrenal gland to produce corticosteroid hormones. Cushings syndrome can come about because of steroid hormones being used to treat an underlying condition or rarely from a tumor of the adrenal gland. The cure of the syndrome depends on its cause. ...Read more

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What sort of disorder is cushing disease?

What sort of disorder is cushing disease?

Cushing's disease: Cushing's disease is a condition where the pituitary (tumor) is producing too much acth (adrenalcorticotropic hormone). This hormone stimulates your adrenal glands to produce extra cortisol (stress hormone) which in excess can cause a lot of metabolic problems. ...Read more

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What are the symptoms of cushing disease?

Many symptoms: Symptoms / signs: truncal obesity (mr. Potatohead look), "moon" facies, thinning of skin, easy bruising, "buffalo" hump in upper back, purple stretch marks, hypertension, fatigue, psychiatric sx, insomnia, excess hair growth, muscle weakness and loss. Symptoms are often progressive and should prompt screening. ...Read more

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What choices do I have for treating cushing disease?

What choices do I have for treating cushing disease?

Options: Cushing's disease is different than cushing's syndrome. Cushing's disease is caused by a tumor or enlargement (hyperplasia) of the pituitary gland. The best treatment is to take it out through surgery. If the surgery is incomplete, radiation treatment can then be used. Lastly, if these treatments are not successful, the adrenal glands may need to be removed to stop the production of cortisol. ...Read more