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Doctor insights on: Csf Pcr Enterovirus

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Have IgG and IgM for CMV but PCR not detected. Pos rmsf IgM neg igg. Bands in CSF mri/white matter foci. Many symptoms possible ms.. No real answers?

Have IgG and IgM for CMV but PCR not detected. Pos rmsf IgM neg igg. Bands in CSF mri/white matter foci. Many symptoms possible ms.. No real answers?

Uncertainty: I am unclear as to what is really going on. Appears that you have immune activity in the central nervous system. You have some cross-reactivity in the serum for CMV and rickettsial infection. Don't think that need to add another disease to the picture. Best to discuss with your doctor or get a second opinion from another specialist. ...Read more

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Polymerase Chain Reaction (Definition)

Polymerase chain reaction is a method of finding a specific piece of dna and copying it over and over again until there is enough to study. The technique allows a scientist to detect very small amounts of dna in a swab sample then reproduce enough of it to study it. It is very sensisitive for detecting the presence of certain bacteria and is also used in doing other ...Read more


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Had HSV DNA PCR test with CSF? Negative. Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

Had HSV DNA PCR test with CSF?  Negative.  Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

No HSV in CNS: With these tests, you're obviously under a doctor's care, maybe including an infectious diseases specialist or neurologist. They can answer these questions best. But these results effectively rule out HSV infection of your central nervous system. Something else is causing the problem. That said, the HSV IgM test is notoriously unreliable. You probably also had an IgG test, probably negative. ...Read more

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What is the definition or description of: CSF culture?

What is the definition or description of: CSF culture?

Meningitis: In order to uncover the culprit in a case of meningitis, spinal fluid is obtained, and an attempt to grow the organism in the lab follows (culture). ...Read more

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What exactly is a CSF culture & what is its purpose? Is it difficult to perform and does it take longer than blood cultures for a result to come back?

What exactly is a CSF culture & what is its purpose? Is it difficult to perform and does it take longer than blood cultures for a result to come back?

Similar to blood: A CSF culture is when you take a sample of CSF (usually from a lumbar puncture which samples the CSF from the spinal canal in the lower back - so yes a bit more difficult to perform but still pretty routine) and culture it to see if there are bacteria (or sometimes viruses) growing in it, usually to look for meningitis. It takes the same amount of time as a blood culture (48 hours). ...Read more

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Why would someone need an enterovirus culture?

Viral cultures: Enteroviruses, such as coxsackie, echo, and polio, replicate in the gastrointestinal track and may cause fever and vague GI symptoms. More serious disease can occur if the virus spread to the central nervous system (causing viral meningitis or even poliomyelitis) or heart (causing myocarditis). The stool, cerebrospinal fluid and heart tissue can be cultured for this group of viruses. ...Read more

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I think I have the enterovirus because I have a cold in the summer. Is this likely the case?

I think I have the enterovirus because I have a cold in the summer. Is this likely the case?

Not enterovirus: Enteroviruses usually cause diarrhea or other intestinal complaints. Other classes of viruses like rhinovirus and adenovirus cause respiratory complaints in the summer. ...Read more

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How serious is enterovirus 68 and is there a test for it?

How serious is enterovirus 68 and is there a test for it?

Depends: Enterovirus 68 has gotten a lot of press recently. It has been causing outbreaks of severe respiratory disease, mainly limited to children with asthma or other respiratory problems. There is no specific treatment, but supportive care is very effective. Fortunately, the fatality rate from the virus is very low with proper supportive care. Hope this helps! ...Read more

Pcr (Definition)

Polymerase chain reaction is used in molecular biology to amplify copies of dna. It is used in dna cloning for sequencing, functional analysis of genes, identification of genetic finger prints, diagnosis of hereditary ...Read more


Cerebrospinal Fluid (Definition)

The fluid that bathes the brain and spinal cord provides an exchange pathway and balancing system for brain and spinal cord metabolism, besides a cushioning system for routine impacts of our ...Read more