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Doctor insights on: Cryoglobulinemia

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Dr. Ihab Ibrahim
12 doctors shared insights

Cryoglobulinemia (Overview)

In cryoglobulinemia blood contains large amounts of cryoglobulins - these abnormal proteins are insoluble at low temperatures. These are present in lot of autoimmune conditions as well as other conditions.


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What are the symptoms of cryoglobulinemia that is linked with amyloidosis?

What are the symptoms of cryoglobulinemia that is linked with amyloidosis?

Cryoglobunliemia: May have no symptoms if cryo levels are low. Cryos can accumulate in the tissues, especially blood vessels. Excess bruising (purpura) on the skin is seen and sometimes a vasculitis (inflammation of the small blood vessels) - especially the lower extremities. Occassionally with very cold weather the fingers may get dark due to sludging. This could even cause damage of the finger tips. So keep warm! ...Read more

Dr. Ihab Ibrahim
12 doctors shared insights

Cryoglobulinemia (Overview)

In cryoglobulinemia blood contains large amounts of cryoglobulins - these abnormal proteins are insoluble at low temperatures. These are present in lot of autoimmune conditions as well as other conditions.


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How can cryoglobulinemia be treated?

How can cryoglobulinemia be treated?

See details: Treatment depends of the area of the body involved and the severity of the involvement. If it is due to an underling disease such as myeloma or hepatitis c, it is often most effective to treat that disease first. Primary cryoglobulinemia is often treated with Prednisone and/or immunosuppressives and occasionally with plasma exchange. ...Read more

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How do I get rid of hyper pigmintattion?

How do I get rid of hyper pigmintattion?

Hydroquinone: Hyperpigmentation if often caused be inflammation du to injury or infection and the action of the sun. Hydroquinone, and sunscreens can revers the process and improve the hyperpigmentation. ...Read more

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How can cryoglobulinemia be treated?

See details: Treatment depends of the area of the body involved and the severity of the involvement. If it is due to an underling disease such as myeloma or hepatitis c, it is often most effective to treat that disease first. Primary cryoglobulinemia is often treated with Prednisone and/or immunosuppressives and occasionally with plasma exchange. ...Read more

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What is the definition or description of: cryoglobulinemia?

What is the definition or description of: cryoglobulinemia?

Insoluble proteins: Cryoglobulinemia is a condition in which a person's blood contains a large amount of a specific type of protein called cryoglobulins. This type of protein can clump up (become insoluble in blood) at reduced temperatures. These insoluble proteins can then block small blood vessels and cause clinical symptoms. Patients with multiple myeloma or hepatitis c can develop cryoglobulinemia. ...Read more

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What are the symptoms of cryoglobulinemia that is linked with amyloidosis?

Cryoglobunliemia: May have no symptoms if cryo levels are low. Cryos can accumulate in the tissues, especially blood vessels. Excess bruising (purpura) on the skin is seen and sometimes a vasculitis (inflammation of the small blood vessels) - especially the lower extremities. Occassionally with very cold weather the fingers may get dark due to sludging. This could even cause damage of the finger tips. So keep warm! ...Read more

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Is it possible for membranoproliferative glomerulonephritis to be caused by mixed cryoglobulinemia?

Is it possible for membranoproliferative glomerulonephritis to be caused by mixed cryoglobulinemia?

Yes: This would be indeed one condition capable of causing immune complex deposition in the glomeruli with associated pattern of membrano proliferative disease in renal histology. ...Read more

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Help please, my doctors think I have cryoglobulinemia that is linked with amyloidosis. What is the cause of this?

Help please, my doctors think I have cryoglobulinemia that is linked with amyloidosis. What is the cause of this?

3 broad : Cryoglobulinemia associated with amyloid is generally due to 1 of 3 causes: 1: an immune blood cell disorder (such as multiple myeloma) 2: an infection ( like hepatitis C) or 3: a "connective tissue" immune disorder such as lupus. Therapy is quite specific for each cause. You should talk with your MD to determine which type of specialist might be needed to clarify the exact cause and best Rx. ...Read more