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Creutzfeldt Jakob Disease And Unsteady Gait
Gait is the way locomotion is achieved using our limbs. Gait is defined as "bipedal, biphasic forward propulsion of center of gravity of human body, in which there is alternate movements of different segments of the body" . Different gaits are characterized by differences in limb movement patterns, overall velocity, forces, ...Read more
Basal ganglia: The area of the brain called basal ganglia has a lot of neurotransmitters like dopamine--some parkinson pt present with dystonia---when parkinson advance and people become rigid they get to be off and on--dystonic alternate with excessive movements. ...Read moreSee 1 more doctor answer
Severe: Mad cow's disease (bovine spongioform encephalopathy =bse) is a very serious incurable disease often with progressive psychological and mental problems associated with rigidity and movement disorders of the extremities fortunately now that we know the etiology very rare the equivalent creutzfeld jacob disease = cjd occurs in one out of a million of the population. ...Read more
A prion disease: Cjd is caused by infection/exposure to an abnormal form of the prion protein (pp). The abnormal form of pp is a completely bent out of shape version of the normal pp . This abnormal shape is very hard for the protein to change to spontaneously, but this can happen (1 in a million people). Once changed the abnormal pp changes other pp's and so on as the disease rapidly spreads/kills the brain. ...Read moreSee 2 more doctor answers
Both are prion DZ's: Creutzfeldt-jakob is the term we use for disease caused by prions when there is no family history or known exposure to prions. Bovine spongiform encephalopathy was a particular strain of slightly-different prions that went epidemic in england from poor meat-industry practices; different pathology and clinical picture. ...Read moreSee 1 more doctor answer
Caused by hospital: Cjd is iatrogenic if the agent which causes the disease, called a prion, is transmitted using contaminated medical instruments or materials. They can contaminate neurosurgical instruments used on the brain of people with the disease. Exposed instruments need very unique sterilization procedures, so rare cases have been reported where the instruments remained contaminated and disease transmitted. ...Read moreSee 1 more doctor answer
Very different: Locked in syndrome is usually the result of an injury to the brainstem that results in a loss of communication between the brain and the spinal cord. Motor neuron disease is a progressive degenerative process that affects the nerve cells that carry signals from the brain to the muscles that allow us to move. The most well known example of this is amyotrophic lateral sclerosis. ...Read moreSee 1 more doctor answer
In creutzfeldt jacob disease (cjd) and/or new variant cjd, is the classical/alternate complement pathway negatively affected in any way?
No: There's no inflammatory response to the prions. Given that everything affects everything else in a petri dish (which is why everything supposedly causes and prevents cancer), i must advise you that this line of inquiry isn't going to lead to anything helpful. I'm glad you have an inquiring mind, thanks for asking. ...Read more
What is progressive neuro-degenerative disease or any neuro-degenerative or atrophy cerebellar diseases or mental diseases?
Example: Neurodegenerative illnesses that affect the cerebellum may be the different forms of multiple system atrophy, such as OPCA. Other neurodegenerative illnesses (that do not affect the cerebellum) include Alzheimers, Parkinsons, and ALS. ...Read more
Usually not similar: Motor neuron disease and spinocerebellar ataxia (sca) are very different diseases. The former affects motor neurons that control voluntary muscle activity, while the latter are a group (nearly 60 different ones currently) of disease that are progressive, degenerative, and affect coordination. Sca-36 does have ataxia in combination with motor neuron disease, but this is the exception not the rule. ...Read more
Without knowing : Your grandparent, i can't say. All dementias are neurodegenerative illnesses in one way or another. And, yes, depression in older patients can present with memory problems. Have your grandparent evaluated by a geriatric psychiatrist to help you figure this out. ...Read moreSee 1 more doctor answer
Diseases like parkinson's, progeria, alzheimer's, leukemia, aids, motor neurone disease etc. Is there hope for any sort of cure?
Description: Static=doesn't change; encephalopathy= a problem that affects the ability of the brain to function This is a description not a disease. It is commonly used to describe the injury that causes cerebral palsy. It can also also be applied to a brain injury from trauma (car crash, fight, fall,etc.) or residual injury from an infection like meningitis. ...Read moreSee 1 more doctor answer
Paralysis of muscles: Lou gehrig's disease is also known as amyotrophic lateral sclerosis. The disease attacks nerve cells in the brain and spinal cord that run the muscles that we can normally control. The cause of the disease is not known. In about 10% it is genetic. People with lou gehrig's disease slowly become weak in the arms and legs, and can have difficulty speaking, swallowing, and breathing. ...Read moreSee 1 more doctor answer
No: Mad cow disease is believed to be a disease caused by the build up (and transmission) of a certain protein in the nerves of our brain. The resultant damage can cause gliosis, but gliosis can also occur in a variety of conditions other than mad cow disease. Gliosis is a term to explain "scarring" in the brain that could be caused by trauma, infections, tumors, radiation therapy, etc. ...Read more
Many things.: Parkinson's Disease will present with physical symptoms such as shakiness, stiffness of the limbs causing a shuffling gait, lack of facial expression causing a mask-like face and the dementia may occur later while Alzheimer's dementia starts with gradual memory problems which begin to get worse in a few years and maybe accompanied with paranoid delusions. ...Read more
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