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Doctor insights on: Crest Scleroderma Symptoms

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What is scleroderma crest variant?

What is scleroderma crest variant?

Limited : The limited cutaneous form of systemic sclerosis is also referred to as crest syndrome. "crest" is an acronym for calcinosis, raynaud's syndrome, esophageal dysmotility, sclerodactyly, and telangiectasia. ...Read more

Dr. Pierre Moeser
185 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


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Ana positive 1:80 homogeneous pattern & 1:160 centromere pattern...Additional tests needed or just by centromere pattern crest & scleroderma r present?

Almost certain: Positive anti-centromere antibodies would indicate the presence of scleroderma/crest, better if anti–scl-70 antibodies also present, plus clinical symptoms and signs. ...Read more

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Is ANA pattern nucleolar with a negative ENA always diffuse scleroderma no symptoms

No: The nucleolar ANA pattern may pop up in a variety of situations, or even fairly low titers in healthy people. And the test is easy to do wrong. This isn't even much of a prediction that you'll develop signs of scleroderma in the future. ...Read more

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Are Parkinson's symptoms & post-polio syndrome symptoms similar?

Are Parkinson's symptoms & post-polio syndrome symptoms similar?

They are different!: Post-polio symptoms emanate from neural changes in the spine, while Dopamine depletion in the substantia nigra is the cause for parkinson's. Stumbling and awkward motion can be common to both, but in the end they are distinctly different. ...Read more

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Ana positive, 1:320 centromere pattern. Some joint pain, some swelling, fatigue. Could I have lupus or scleroderma?

Ana positive, 1:320 centromere pattern.  Some joint pain, some swelling, fatigue.  Could I have lupus or scleroderma?

See below: Lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. The information you provided suggests scleroderma/crest. See this site for more info and discuss with your doctor. http://www.mayoclinic.com/health/scleroderma/ds00362. ...Read more

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Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Occam's Razor: Usually Systemic Sclerosis and/or limited Scleroderma is not characterized by arthritis like you describe. The typical biomarker the anti Scl-70 (anti-topoisermorase). Symptoms have to be put into context and better described than elbow and forearm pain. This one you should see a rheumatologist about. Dermatology would be useful as well. Best of luck! ...Read more

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Does crest syndrome always have noticeable symptoms?

Not necessarily: No, milder forms of crest syndrome are diagnosed late as the symptoms from one or more of the five conditions within crest are not noticeable. ...Read more

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What are signs, symptoms of scleroderma?

What are signs, symptoms of scleroderma?

Tight skin: People with scleroderma have tight skin, but have other findings including raynauds, finger changing color in the cold or stress, joint pain, and can have internal involvement in the lungs, heart, kidney etc. Each person has different finding and the rheumatologist helps to put it together. ...Read more

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Which symptoms 1st appear in someone with lupus or scleroderma?

Which symptoms 1st appear in someone with lupus or scleroderma?

It depends: There are several different symptoms that can appear, but it all depends on the patient. ...Read more

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Anxiety, depression, weakness, fasciculations, neuropathy sensations, tinnitus along with lupus symptoms. Possible to have CNS lupus with negativeana?

Anxiety, depression, weakness, fasciculations, neuropathy sensations, tinnitus along with lupus symptoms. Possible to have CNS lupus with negativeana?

Complex question : Large differential diagnosis here. See a neurologist and rule out ms and other neurological, tumors, toxic, metabolic, infectious causes .... Labs and imaging studies. ...Read more

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What is the best climate for me. I have lupus scleroderma RA fibromyalgia and crest syndrome ?

What is the best climate for me. I have lupus scleroderma RA fibromyalgia and crest syndrome ?

The Mighty Vitamin D: You may do better in warmer climate closer tot he equator for 2 reasons: more vitamin D and more exercise . Receiving more sunlight would naturally raise your vitamin D levels. Adequate vitamin D is essential for fibromyalgia relief, and is a powerful anti-inflammatory.More exercise, especially light walking or yoga on the beach would add to the benefit of vitamin D. ...Read more

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What are the symptoms of systemic lupus erythematosus?

What are the symptoms of systemic lupus erythematosus?

Many: People with lupus may have joint pain, skin rashes, chest pain, heart probelms, hair loss, fingers changing color in the cold, rash in the sunshine, neuro-psychologic problems. These are only soemof the symtpoms peopel can have. They can also have none of these. Your physician will evaluate all of these, get labs tests and imaging. ...Read more

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Dr. Thomas Fiala
144 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more