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Doctor insights on: Creatine Kinase Isoenzymes

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Creatine Kinase (Definition)

Creatine kinase is an enzyme found in muscles throughout the body. There are different subtypes of the enzyme, called isoforms, which predominate in different organs. For instance, the isoform in skeletal muscles is different from that which is most heavily found in the heart muscle. A blood tests detects levels of this in the body, for example if ...Read more


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Elevated total creatine kinase with normal isoenzymes. What does this mean?

Elevated total creatine kinase with normal isoenzymes. What does this mean?

CPK: Ck is a polycomponent muscle enzyme. The ck mb is the muscle-brain part of ck total. That is why the lower value for mb. The lab normals would tell whether these are elevated or not. Elevations are usually from muscle damage and the mb is found in heart. ...Read more

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What supplements would lower creatine kinase levels. ?

What supplements would lower creatine kinase levels.

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None: No supplements will lower creatine kinase which signifies potential muscle breakdown when elevated. In past, we tested CK when we suspected a heart attack. Levels can also be elevated when muscles are damaged (rare condition = rhabdomyolysis). Check out http://labtestsonline.org/understanding/analytes/ck/tab/test/ & http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8336 ...Read more

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What are ldh isoenzymes?

What are ldh isoenzymes?

Obsolete test: There are five forms of the ldh enzyme. Type i is especially abundant in heart, and if it was higher than type ii, it was a marker for heart attack. If all five were equally high, think infectious mono, type v was marker for skeletal muscle or liver injury, and so forth, type iii for a lung infarct. It was helpful but today's labs are more sensitive and more specific. ...Read more

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Are creatinine kinase levels elevated during weight lifting?

Are creatinine kinase levels elevated during weight lifting?

Yes: Creatinine kinase can be high after a vigorous exercise routine. Maintaining good hydration is important to clear it from the body. ...Read more

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What could increased creatine kinase and aldolase levels indicate?

What could increased creatine kinase and aldolase levels indicate?

Likely muscle injury: Creatine kinase and aldolase would both be elevated after a muscle injury. Ck can also be elevated in kidney failure. Adolase can be sub-classified into a, b and c which helps differentiate from which tissue the high levels came. ...Read more

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Elevated total creatine kinase with normal isoenzymes. What does this mean?

CPK: Ck is a polycomponent muscle enzyme. The ck mb is the muscle-brain part of ck total. That is why the lower value for mb. The lab normals would tell whether these are elevated or not. Elevations are usually from muscle damage and the mb is found in heart. ...Read more

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Would troponin, Creatine kinase and/or CK-MB be elevated with myocarditis and pericarditis?

Would troponin, Creatine kinase and/or CK-MB be elevated with myocarditis and pericarditis?

Yes: The level of rise would depend on the amount of damage to the myocardial cells. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. ...Read more

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Does creatine kinase only rise with muscle injury?

Does creatine kinase only rise with muscle injury?

Muscle and Brain: Creatine kinase is present in skeletal muscle, heart, smooth muscle and brain and injury to any of these can cause elevation of this enzyme. ...Read more

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Is creatine Kinase typically elevated in ALS patients?

Is creatine Kinase typically elevated in ALS patients?

Below: Serum creatine kinase (CK) levels were recorded in 100 patients with amyotrophic lateral sclerosis (ALS). CK concentrations were elevated in 43% of the patients, with a mean level of 240 U/liter and a range of 59-1,327 U/liter (male normal less than 95 U/liter, female normal less than 59 U/liter). All patients with elevated CK had muscle weakness. Seven patients were initially misdiagnosed as hav ...Read more

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Does statins cause elevated creatine?

Does statins cause elevated creatine?

statins: Sometimes creatine phosphokinase levels are elevated in people taking statins. Some people having statin related muscle pains get relief from creatine supplements. What all this means is still under study. ...Read more

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Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Increased aldolase,  complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Complicated: When i was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more

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Can statin drugs increase creatinine level?

Can statin drugs increase creatinine level?

Yes: While very uncommon, all of the statin drugs have been known to cause muscle injury. The release from injured muscle of a substance called myoglobin can plug up the kidneys and cause the creatinine to rise. However, under those circumstances there is usually significant muscle pain or weakness and often the urine has a reddish appearance. Also a muscle enzyme (CPK) will be strikingly elevated. ...Read more

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What is difference of creatinine serum VERSUS creatine kinas total serum?

Different tests: Creatinine is a waste product of (mainly muscle) metabolism, & builds up when the body (kidney) cannot get rid of it. Creatine Phosphokinase, AKA Total CPK, is an enzyme produced by certain cells in the body that produces creatine byproducts (muscle, bone, brain, heart have CPK). An elevated CPK means one of these organs is/was damaged in some way. So the 2 tests measure different things. ...Read more

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Testosterone and creatinine clearance?

Clarify: I'm not sure what your question is. Testosterone should be used with caution in patients with conditions involving edema, such as impaired kidney function, as the hormone may worsen edema. One of the adverse effects of testosterone is an increase in serum creatinine concentration. ...Read more

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What could cause an elevated creatine kinase test?

What could cause an elevated creatine kinase test?

Muscle injury: Creatinine kinase is released from injured or dead muscle cells, be those skeletal, cardiac of smooth muscle cells. Renal failure is also associtated with modestly elevated levels. ...Read more

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Why would need a serum creatine kinase measurement?

Why would   need a serum creatine kinase measurement?

Muscel injury: Ck levels are elevated with muscle injury. All muscles, skeletal, cardiac and smooth muscles release ck on injury. Some drugs and alcohol can also damage muscle and cause high ck. ...Read more