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Doctor insights on: Cpk Levels In Muscular Dystrophy

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Muscilar dystrophy related to dystrophin protein?

Muscilar dystrophy related to dystrophin protein?

Two types: The most common is duchennes with beckers a distant second. Both are related to muscle protein abnormal structure. ...Read more

Dr. Kathryn Mosher
141 doctors shared insights

Muscular Dystrophy (Definition)

Muscular dystrophy includes a number of disorders which are associated primarily with abnormalities of the architecture of the cells, often causing changes in size and function (weakness). These disorders are typically inherited, and recognized early in life, although there are of course exceptions to this. Prognosis is based on the type of MD and expression ...Read more


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What causes creatinine kinase levels to rise with muscle weakness?

What causes creatinine kinase levels to rise with muscle weakness?

Damage to muscle: The correct term is creatine kinase (ck). Creatinine is something else. Useful to know: most "muscle" weakness is actually caused by nerve, not muscle, malfunction. True muscle weakess: myocytes (muscle cells) contain lots of the enzyme ck. Low levels are found in blood normally. Damage to myocyte cell membranes from a variety of causes causes leakage of ck into the blood. Recovery->normalization. ...Read more

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If CPK reduces does it help in duchnne muscular dystrophy?

If CPK reduces does it help in duchnne muscular dystrophy?

Not really: CPK / ck / creatine kinase is high in duchenne's because it leaks from the cells carrying the abnormal gene. Levels fluctuate in dmd patients as in everyone else with activity, and toward the end they may drop as muscle mass diminishes. Dmd is a cruel disease and if you or someone close to you is affected, you have my sympathy. Thank you for asking. ...Read more

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How are duchennes muscular dystrophy and myotonic muscular dystrophy different?

Amount of Dystrophin: The two conditions differ in their severity, age of onset, and rate of progression. Mutations in the dmd gene cause duchenne and becker forms of muscular dystrophy (dmd and bmd, respectively). Mutations that lead to an abnormal version of dystrophin that retains some function usually cause bmd, while mutations that prevent the production of any functional dystrophin causes dmd. ...Read more

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Is duchenne muscular dystrophy more prominent in certain ethnicities?

Is duchenne muscular dystrophy more prominent in certain ethnicities?

Duchenne: It is an x linked (from the mother) defective gene. Therefore it effects only boys. Not aware of an ethnic predilection. ...Read more

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Where does duchenne muscular dystrophy strike most in the body?

Where does duchenne muscular dystrophy strike most in the body?

Mutations in the : dystrophin gene, Xp21.2-p21.1, causes weakness in large, then small, skeletal muscles. Weakness of heart muscle, smooth muscle of GI tract & urinary tracts, Speech Sound Disorder, Intellectual Disability, Specific Learning Disability & behavior problems occur in some boys. Carrier girls may have cardiomyopathy. Specific mutations determine manifestations in boys & carrier girls. See mda.org. ...Read more

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How can one differentiate between duchenne muscular dystrophy and spinal muscular atrophy?

Diagnostics: Muscle biopsy or EMG will be able to differentiate. Presenting symptoms may lead one to be suspected more than the other as well. ...Read more

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What are the differences between duchennes muscular dystrophy and myotonic muscular dystrophy?

Both are inherited: neuromuscular disorders. DMD is caused by mutatation(s) on Chr. X. Onset of rapidly progressive muscle atrophy starts early in boys. Female carriers can have heart muscle disease. MD 1 is caused by mutant genes on Chr. 19; MD 2 by mutant genes on Chr. 3, Each child of a parent affected by either has a 50% chance of inheriting it, often with earlier & more severe symptoms than the parent's. ...Read more

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Does creatine kinase only rise with muscle injury?

Does creatine kinase only rise with muscle injury?

Muscle and Brain: Creatine kinase is present in skeletal muscle, heart, smooth muscle and brain and injury to any of these can cause elevation of this enzyme. ...Read more

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Is creatine Kinase typically elevated in ALS patients?

Is creatine Kinase typically elevated in ALS patients?

Below: Serum creatine kinase (CK) levels were recorded in 100 patients with amyotrophic lateral sclerosis (ALS). CK concentrations were elevated in 43% of the patients, with a mean level of 240 U/liter and a range of 59-1,327 U/liter (male normal less than 95 U/liter, female normal less than 59 U/liter). All patients with elevated CK had muscle weakness. Seven patients were initially misdiagnosed as hav ...Read more

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Can muscular dystrophy be only in one muscle?

Called atrophy: Dystrophy is a term reserved for a form of muscle disease (dys= problem with, trophy=growth) localised loss of muscle balk is called atrophy and is usually related to disuse or lower motor neuron problems. ...Read more

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What causes muscular dystrophy to run in families?

It's in the genes!: Many muscular dystrophies are caused by a defect in the genes. These defects are passed on to our children. Some are dominant meaning there is a 50/50 chance of passing it along, others are linked to gender or are recessive meaning you have to reproduce with someone with the same defect to have a child who is affected. ...Read more

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Is it safe to give blood with mitochodria myopathy muscular dystrophy?

Is it safe to give blood with mitochodria myopathy muscular dystrophy?

S Yes but: It is a genetic not transmitted disorder which is quite rare, but unfortunately many genetic disorders though not transmitted except possibly to offspring are often refused as donors at most blood banks. I know, because I have one (hemochromatosis). It`s no reflection on you. ...Read more

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Which chromosome is affected by duchenne muscular dystrophy (dmd)?

X chromosome: The gene for the abnormal protein is located on the x chromosome. Hence it is "x linked" . Mostly boys are affected. ...Read more

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Dr. Jay Park Dr. Park
3 doctors agreed:
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How come duchenne muscular dystrophy considered a genetic disorder?

Dr. Jay Park Dr. Park
3 doctors agreed:

Mutated gene in X : Duchenne muscular dystrophy is caused by an abnormal gene in x chromosome, and is inherited as an x-linked recessive trait. ...Read more

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Can muscular dystrophy be isolated to one single muscle?

Can muscular dystrophy be isolated to one single muscle?

No.: Muscular dystrophy is a group of inherited diseases which cause progressive weakness of muscles that allow movement. Muscular dystrophy usually will affect every muscle in a person with the disease. Symptoms may be more noticeable at first in one muscle but will progress. In one type of muscular dystrophy, the symptoms predominately affect muscles in the shoulder and pelvic girdles. ...Read more

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Why is lactate dehydrogenase in different forms in the heart, kidneys and skeletal muscle?

Why is lactate dehydrogenase in different forms in the heart, kidneys and skeletal muscle?

All over: Ldh is a non specific enzyme that is found in many areas Not a specific are has minimal utility in clinical medicine ...Read more

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What can extreme high levels of creatine kinase (skeletal muscle enzymes) be the result of?

What can extreme high levels of creatine kinase (skeletal muscle enzymes) be the result of?

Just being fit: The reference range is set on the assumption that you don't exercise. Fitness types routinely have values way up in the thousands. No need to limit your fun in the gym. ...Read more

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Why would a person with myotonic muscular dystrophy fall?

Why would a person with myotonic muscular dystrophy fall?

Can not relax muscle: This form of muscular dystrophy also features an inability to relax muscles at will. It most often begins in early adulthood. Muscles of the face are usually the first to be affected. ...Read more

Creatine Kinase (Definition)

Creatine kinase is an enzyme found in muscles throughout the body. There are different subtypes of the enzyme, called isoforms, which predominate in different organs. For instance, the isoform in skeletal muscles is different from that which is most heavily found in the heart muscle. A blood tests detects levels of this in the body, for example if ...Read more