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Doctor insights on: Cortisol Binding Globulin

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I have a swollen painful leg. I had a d-dimer 300, globulin 36 & neutrophil 6.44. Recent test anti-cardiolipin IgM was in 82u/ml pt 13.8 is it ok?

I have a swollen painful  leg. I had a d-dimer 300, globulin 36 &  neutrophil 6.44. Recent test anti-cardiolipin IgM was in 82u/ml pt 13.8 is it ok?

Cause of leg pain: Superficial phlebitis can cause this as well as non thrombotic problems such as cellulitis, infections, connective tissue problems etc. See a doc to separate out the confusion. There is always a reason for a painful leg. ...Read more

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What does it mean if my testosterone is normal but I have a low level of sex hormone binding globulin?

What does it mean if my testosterone is normal but I have a low level of sex hormone binding globulin?

Free Testosterone: Hi. If your total testosterone is normal and you have low SHBG, you have a plenty normal free testosterone. Therefore, you're eugonadal (normal pituitary and gonadal function). ...Read more

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How can you get pregnant if you have high sex hormone binding globulin?

How can you get pregnant if you have high sex hormone binding globulin?

Shbg: Elevated shbg can decrease available sex steroids which can have a physiologic effect. This effect is part of the mechanism of action of oral contraceptives. Avoid meds or plant sources of estrogen (excessive soy). Many can self regulate because the feedback inhibition of the pituitary responds to free and not bound hormone. ...Read more

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What to do if I have very low cortisol blood levels but very high saliva, both the same day and time, why is that?

What to do if I have very low cortisol blood levels but very high saliva, both the same day and time, why is that?

CBG: Hi. There is a blood protein that binds cortisol called cortisol-binding globulin (CBG). Some people are genetically lacking CBG, so that large fraction of bound (kind of inert) cortisol is missing, and their cortisol blood levels are much lower. CBG does not go into saliva, but cortisol does. Without knowing more details, that could account for the differences. ...Read more

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Total ck, sed rate, ana, ip ace, serum protein panel normal but gamma globulin (.6) cortisol am (30.8) Hx of low vit d and K. What could this mean?

Total ck, sed rate, ana, ip ace, serum protein panel normal but gamma globulin (.6) cortisol am (30.8)
Hx of low vit d and K. 
What could this mean?

Not much-: An important thing to remember is that lab results are not useful unless there is a clinical context. Advice is based on focusing on the patient, not the numbers. Though you mention a history of low vit D and K, did symptoms exist when the labs were drawn? Why were they drawn in the first place? Otherwise, it is best to ask your ordering doctor what the results mean. ...Read more

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Thyroxin binding globulin mine is 19 new dr checked it what's is the difference to thyroglobulin? Mines 19 but tg is .6.

Thyroxin binding globulin mine is 19 new dr checked it what's is the difference to thyroglobulin? Mines 19 but tg is .6.

Unusual measurements: Tbg increases with Estrogens and other conditions and increases the total t4. However, all this is irrelevant if your doctor measures free T4 and tsh, which accounts for thyroxine binding. I do not understand why your doctor is measuring tbg. To assess the thyroid status of someone who has had a thyroidectomy and is on synthroid, all you really need is a tsh. ...Read more

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What is the definition or description of: sex hormone binding globulin?

What is the definition or description of: sex hormone binding globulin?

See below: Sex hormone-binding globulin (shbg) or sex steroid-binding globulin (ssbg) is a glycoprotein that binds to sex hormones, to be specific, androgens and estrogens. Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. ...Read more

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What can decrease the serum levels of sex hormone binding globulin?

What can decrease the serum levels of sex hormone binding globulin?

Exercise & fat loss: Sex hormone binding globulin (shbg) is related to estrogen levels which are related to body fat. So the non-drug way to get around this is via exercise & nutrition in order to get rid of excess body fat, esp around your gut. If you can't lower your estrogen levels enough, some physicians (myself included) will attempt an off-label trial of an aromatase inhibitor to stop your body's conversion of t. ...Read more

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Can you get a girl pregnant if you have low sexual binding globulin?

Can you get a girl pregnant if you have low sexual binding globulin?

It's possible: Sex-steroid binding globulins affect the levels of hormones (both male and female hormones). Some hormone deficiencies can cause fertility problems, but they certainly are not specifically effective in preventing pregnancy. If you are trying to conceive, see a doctor. If you are trying not to conceive, see a doctor! ...Read more

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How can you get pregnant if you have high sex hormone binding globulin?

Shbg: Elevated shbg can decrease available sex steroids which can have a physiologic effect. This effect is part of the mechanism of action of oral contraceptives. Avoid meds or plant sources of estrogen (excessive soy). Many can self regulate because the feedback inhibition of the pituitary responds to free and not bound hormone. ...Read more

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What supplements can decrease the levels of sex hormone binding globulin?

What supplements can decrease the levels of sex hormone binding globulin?

Don't know of any: Shbg is affected by sex hormones. Estrogen increases and male hormones including testosterone decreases shbg. Lowering Insulin levels with a very low carbohydrate high fat diet will improve metabolic health that would ultimately increase shbg. ...Read more

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My testosterone is normal but I have a low level of sex hormone binding globulin. why?

My testosterone is normal but I have a low level of sex hormone binding globulin. why?

Testosterone: Missing from your question is whether you have a problem with erections and/or ejaculation. Please let me know when you have those answers. ...Read more

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Cancer patient new dr checked thyroxin binding globulin not thyroglobulin what is the difference?

Cancer patient new dr checked thyroxin binding globulin not thyroglobulin what is the difference?

You would: Have to ask your doctor for the reason. The two test measure totally different things and are utilized in totally different situations. ...Read more

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What does it mean if my testosterone is normal but I have a low level of sex hormone binding globulin?

Free Testosterone: Hi. If your total testosterone is normal and you have low SHBG, you have a plenty normal free testosterone. Therefore, you're eugonadal (normal pituitary and gonadal function). ...Read more

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What is the exact formula for calculating free testosterone based on total testosterone, albumin and sex hormone binding globulin?

What is the exact formula for calculating free testosterone based on total testosterone, albumin and sex hormone binding globulin?

Several available: Check out http://www.Issam.Ch/freetesto.Htm for a free testosterone calculator available online. Check out http://www.Eje-online.Org/content/152/3/471.Full for study regarding accuracy of several other calculators. ...Read more

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What does it mean if I am a female, have normal estrogen, testosterone & TSH, but low sex hormone binding globulin?

Nothing - u r normal: Regardless of gender, if your estrogen, testosterone & TSH are normal, then you're normal. Sex hormone binding globulin is used to bind up sex hormones, exactly what it says. Sometimes we check both total hormone as well as free hormone, since it's typically free hormone that accounts for benefit claimed by hormone. But rather than look at numbers, consider how you feel. We treat patients, not #s. ...Read more

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Can you tell me about normal testosterone, estrogen and TSH but low sex hormone binding globulin (female)?

Can you tell me about normal testosterone, estrogen and TSH but low sex hormone binding globulin (female)?

You're normal!: Regardless of gender, if your estrogen, testosterone & TSH are normal, then you're normal. Sex hormone binding globulin is used to bind up sex hormones, exactly what it says. Sometimes we check both total hormone as well as free hormone, since it's typically free hormone that accounts for benefit claimed by hormone. But rather than look at numbers, consider how you feel. We treat patients, not #s ...Read more

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Birth control upregulates sex hormone binding globulin SHBG allowing it to bind to more circulating Free Testosterone. will my levels ever be normal ?

Birth control upregulates sex hormone binding globulin SHBG allowing it to bind to more circulating Free Testosterone. will my levels ever be normal ?

Need more info: What are your levels. Are they high? What symptoms do you have? Lab numbers by themselves have very little value. One has to know the clinical setting to be able to interpret them correctly. ...Read more

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What might expln: tsh:2.475, t3:3, t4:1.1, testo.F:1.8, test.T:38 similarly fsh, lh, 17hydrox all normal -but sex hormone binding globulin elevated at 184?

What might expln: tsh:2.475, t3:3, t4:1.1, testo.F:1.8, test.T:38 similarly fsh, lh, 17hydrox all normal -but sex hormone binding globulin elevated at 184?

Need reverse T3 (liothyronine): Just commenting on the thyroid labs: i think you may have a slight hypothyroid problem, but hard to tell without complete labs. Is the T3 (liothyronine) a total or free? Also reverse T3 (liothyronine) needs to be done to know for sure. ...Read more

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