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Doctor insights on: Coombs Test Positive Newborn

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Newborn had positive Coombs test - I'm O positive and he's B positive. He didn't develop jaundice. How common is a positive Coombs test in newborns?

Newborn had positive Coombs test - I'm O positive and he's B positive. He didn't develop jaundice. How common is a positive Coombs test in newborns?

Common.: About 1 out of 3 pregnancies where the mother and child are ABO incompatible will be Coombs positive, but actual hemolytic disease of the newborn is rare. Only IgG type anti-A or anti-B cross the placenta, which most people don't express. Second the A and or B antigen is not heavily expressed on fetal cells. Also other cells besides RBCs express A and or B and "soak up" the antibodies. ...Read more

Coombs Test (Definition)

Coombs serum is an antibody directed against other antibodies that makes antibody-coated red cells stick together. The direct Coombs test seeks antibodies on a patient's own red cells that may be causing red cell damage and perhaps anemia. The indirect Coombs test is used in blood banking to determine what antigens are present on unknown red cells by seeing ...Read more


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I am rh- and my boy friend is rh- so will my babys indirect Coombs test came back positive?

I am rh- and my boy friend is rh- so will my babys indirect Coombs test came back positive?

Baby is also Rh-: Your baby will also be rh-. Because rh- is recessive to rh+ you and your boyfriend both have two rh- genes. Your haplotype is rh-/rh- and your phenotype rh- and so is his. You and he can only give rh- genes to your babies. All of your babies with this father will be rh-/rh-. Don't sweat it. ...Read more

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Hi my Coombs test is positive what I have to do? What is the next step?

Hi my Coombs test is positive what I have to do? What is the next step?

Let me explain: The direct Coombs test is used to test for autoimmune hemolytic anemia; ie, a condition of a low count of red blood cells (aka rbcs) caused by immune system lysis or breaking of rbc membranes causing rbc destruction. Follow hematologist direction for the treatment and precautions. ...Read more

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I`m pregnant, have rh-positive blood type and Coombs test is positive. It`s my second pregnancy, in first I had negative coombs. Will my baby be ok?

I`m pregnant, have rh-positive blood type and Coombs test is positive. It`s my second pregnancy, in first I had negative coombs. Will my baby be ok?

Unsure: You will likely need to have additional testing done during the pregnancy to determine if there is any compromise of the fetus. If there is a problem with the fetus due to rh iso-immunization, then there are interventions that can improve the outcome. Keep your appointments. ...Read more

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Would it be possible for a body to have adjusted to autoimmune hemolytic anemia over time. I have had fatigue, low grade fevers, positive coombs test, and an alarming drop in blood levels after surgery not losing much. Labs come back low normal.

Would it be possible for a body to have adjusted to autoimmune hemolytic anemia over time. I have had fatigue, low grade fevers, positive coombs test, and an alarming drop in blood levels after surgery not losing much. Labs come back low normal.

Worth knowing: Let's finish your workup. Plenty of folks are Coombs-positive but not hemolyzing. If your reticulocyte count is up and you're well-nourished and aren't iron-deficient and it's been a while since surgery, maybe you're hemolyzing -- a reticulocyte count will tell you. With Coombs-pos, fatigue, low-grade fever, get tested for lupus. Your physician needs these missing pieces. ...Read more

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What is the definition or description of: Coombs test?

What is the definition or description of: Coombs test?

Red cell antibodies: Coombs serum is an antibody directed against other antibodies that makes antibody-coated red cells stick together. The direct Coombs test seeks antibodies on a patient's own red cells that may be causing red cell damage and perhaps anemia. The indirect Coombs test is used in blood banking to determine what antigens are present on unknown red cells by seeing what antibodies they bind. ...Read more

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What are the differences between direct Coombs test and indirect Coombs test?

What are the differences between direct Coombs test and indirect Coombs test?

Both test Ag-Ab rxns: Direct Coombs will test for the reaction using the patient’s RBCs, if there is a reaction, then the direct test is positive, used to test for autoimmune hemolytic anemia.
Indirect Coombs test uses the patient’s serum (not rbcs) which is added to rbcs that are known to have a certain antigenicity, positive in cases of hemolytic diseases of the newborn, mother's serum against baby's RBCs, ...Read more

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What is the difference between the direct Coombs test and indirect Coombs test?

What is the difference between the direct Coombs test and indirect Coombs test?

Bound vs unbound ABs: Direct coombs' test is used to detect antibodies that are already bound to the surface of red blood cells. Many diseases and drugs (quinidine, methyldopa, and procainamide) can lead to production of these antibodies

indirect coombs' test looks for unbound circulating antibodies against a series of standardized red blood cells. The indirect coombs' test is only rarely used to diagnose a condition. ...Read more

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What is the indirect and direct Coombs test?

What is the indirect and direct Coombs test?

RBC antibodies: These tests are used to detect antibodies against red blood cells (rbcs). The direct Coombs test is used in autoimmune hemolytic anemia. That's when your antibodies attack & destroy you own rbcs. The indirect test is used to detect potential transfusion reactions & in pregnancy especially for rh incompatibility when mom is rh- & fetus is rh+. For a more complete explanation see wikipedia. ...Read more

Lena Caron Dr. Caron
3 doctors agreed:
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S there difference between indirect and direct Coombs test?

Lena Caron Dr. Caron
3 doctors agreed:

Yes: The direct Coombs test is typically used to test for autoimmune hemolytic anemia, a disorder involving destruction of red blood cells. It determines whether or not antibodies are present on the surface of the patient's rbcs. The indirect Coombs test is typically used to test for blood type compatibility prior to a transfusion, and detects the presence of antibodies in the serum of the patient. ...Read more

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Why can't you donate plasma with an abnormal indirect Coombs test result?

Why can't you donate plasma with an abnormal indirect Coombs test result?

Antibody to red cell: A person with positive indirect Coombs test has antibodies to red cells. If such plasma is transfused into a person, s/he could suffer loss of her/his own red cells. ...Read more

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Is the direct Coombs test done at birth testing the baby or the mother? Whose Coombs is being tested?

Is the direct Coombs test done at birth testing the baby or the mother? Whose Coombs is being tested?

Baby's Red cells and: Mother's antibodies. The Direct Coombs test in a newborn is done to look for maternal antibodies that may have coated the baby's red cells. So, in a way both are being tested, but it is mainly to test for maternal antibody induced hemolytic anemia in the baby. ...Read more

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I am b - hubby is o +. I am not pregnant but before pregnancy can I get the indirect Coombs test done to check if my blood is sensitized?

I am b - hubby is o +. I am not pregnant but before pregnancy can I get the indirect Coombs test done to check if my blood is sensitized?

Ask OB/Gyn: Easier and safer to get Rhogam shot to provide passive protection to fetus, if are or might become sensitized to (+) due to any peri-placental sharing. ...Read more

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If mother is o positive and baby is a or b postive, how many will test postive for direct Coombs at birth? My Son did but didn't have jaundice.

If mother is o positive and baby is a or b postive, how many will test postive for direct Coombs at birth? My Son did but didn't have jaundice.

Not automatic: If there are minor blood type incompatibilities, like ABO, not every doctor will test every baby with a direct Coombs. Some only test if the baby shows signs of early jaundice. So it's very difficult to say the exact percentage who are positive because not every baby who fits the question is even tested, let alone keeping track of how many are positive. Being + doesn't equal jaundice as you've seen ...Read more

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We got a score of.87 on our newborns c5oh test and he is considered positive. What does this mean?

We got a score of.87 on our newborns c5oh test and he is considered positive. What does this mean?

Metabolic: Disorders can give elevated acylcarnitine levels. The definitive test to explore this screening result will be urine organic acids on infant and mother, plasma acylcarnitine analysis, and serum biotinidase assay. Other tests may be needed and a geneticist will be consulted. This level will require prompt testing so that if it is confirmed to be an error in metabilism your baby can be treated now. ...Read more

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Is it necessary to have a confirmatory test if found positive in g6pd newborn screening?

Usually not...: If a baby is found to have g6pd deficiency on newborn screening, it usually means that the infant actually has it. The test can be falsely negative in certain circumstances, but a positive test is usually accurate. That being said, different states use different tests. I would 1st talk with your pediatrician about this, then they may refer you to hematologist to get guidance on living with g6pd. ...Read more

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What should I do if my newborn's meconium tests positive for opiates?

What should I do if my newborn's meconium tests positive for opiates?

Hard to say: Meconium will hold traces of drug exposures for months. This includes any prescription or non prescription drug. In some cases it is used in child protection evaluations. A positive test does not necessarily translate into any problems for baby. You will need to provide information to verify where exposure occurred. ...Read more

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If I shot heroin 3 times during my relapse stage up til 19 weeks pregnant, before I knew I was pregnant. Will my newborn test positive at birth.?

If I shot heroin 3 times during my relapse stage up til 19 weeks pregnant, before I knew I was pregnant. Will my newborn test positive at birth.?

Depends on what...: If they test urine, unlikely to test positive. However if they test meconium, cord or hair/nails, they could show positive results. It really is just better for ALL involved (you, your baby and your OB) if you just admit the use of the heroin now to your OB so they can appropriately watch the baby. That baby spent half of your pregnancy exposed, especially in first trimester, so OB NEEDS to know. ...Read more

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Can an epinephrine injection into the mother's i.V during labor cause a newborn to test positive for methamphetimine?

Can an epinephrine injection into the mother's i.V during labor cause a newborn to test positive for methamphetimine?

Drug Testing: Nope. Not in any way. If you have been using methamphetamines it is best now to come clean. It is best to get the baby tested appropriately so that they do not have any health consequences.

Every single doctor here would agree that we want you healthy, sober, in recovery where you can be the very best mom possible.

Or, if you are going to use methamphetamines perhaps adopting the baby out.. ...Read more

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Can a newborn baby test positive for marijuana if the mother wasn't? The mother was always closed up with boyfriend & he smoked constantly but she never did while she was pregnant & never tested postive during th whole pregnancy.

Can a newborn baby test positive for marijuana if the mother wasn't? The mother was always closed up with boyfriend & he smoked constantly but she never did while she was pregnant & never tested postive during th whole pregnancy.

Possible/unlikely: You would only be tested if for some reason you end up on the risk list and they look. Babies first poo can contain traces of drug exposure as far back as several months, and those tests are looking for any, not the amount. Heavy drug use by one parent might get you into problems with the Child and family services anyway. They would notice the smell. ...Read more

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Can a newborn baby test positive for marijuana if the mother wasn't? The mother was always closed up with boyfriend & he smoked constantly but she never did while she was pregnant & never tested postive during th whole pregnancy.

Can a newborn baby test positive for marijuana if the mother wasn't? The mother was always closed up with boyfriend & he smoked constantly but she never did while she was pregnant & never tested postive during th whole pregnancy.

Testing differences: When I test a baby I do so o n their 1st poo, which can retain any evidence of drug exposure for the preceding months. Mother doesn't have to be a smoker for 2nd hand smoke to turn baby positive. In my state, baby would go home in foster care and the next year or more would be a nightmare for everyone. ...Read more

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Am 16weeks pregnant and I tested coombs Indirect positive. Can it affect the baby or makes the baby abnormal?

Am 16weeks pregnant and I tested coombs Indirect positive. Can it affect the baby or makes the baby abnormal?

It refers to blood: You have red blood in you as does your husband. On the outside of the cells there are sugar molecules- either A or B or neither. Each of you will contribute the genes so the infant will get one from you and one from him and have either type A or type B or type AB or type O (neither). There is another Rh system. The Coombs refers to antibodies that you have against blood cells. Disc with your OB ...Read more

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Am 16weeks pregnant and this is my second pregnancy. I tested coombs Indirect positive. Can it affect the baby or makes the baby abnormal?

Am 16weeks pregnant and this is my second pregnancy. I tested coombs Indirect positive. Can it affect the baby or makes the baby abnormal?

Which antibody?: It sounds like you are referring to an antibody screening test which is done on all pregnant women. Some antibodies are significant during pregnancy, some only matter if you are receiving blood during a transfusion and others do not matter at all. Ask your doctor to go over your specific test result and explain the clinical significance ...Read more

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How far back does a newborns drug test go?

How far back does a newborns drug test go?

Depends: The type of test will determine the sensitivity and time frame covered.Urine tests often covers the preceding week or so. Meconium tests can cover a month or more. ...Read more

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How do they test newborn for illegal drugs>?

How do they test newborn for illegal drugs>?

Drug screening: A urine specimen can be collected on the baby and sent for a drug screen just like it is done on the mother. Also, the first stool of the baby (meconium) can be analyzed for drugs. The meconium will reveal the illegal drugs mom has taken since about 20 weeks gestation. Also an umbilical cord specimen and hair analysis can be done in some special labs. ...Read more

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Can someone tell me about tests in newborn for galactosemia?

Simple: Ask for a blood galactose. I don't know why you ask but if there is any suspicion the disease is exacebated by milk. Its effect is to cause cataracts, one of the few causes of this in infancy. ...Read more

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What are the tests for transient neonatal pustular melanosis?

Visual Diagnosis: This benign skin condition seldom warrants any tests. A scraping of the pustules reveals white cells & eosinophils without germs. The eruption pattern & lack of inflammation separate it from other entities. ...Read more

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What are the tests for neonatal seizures?

What are the tests for neonatal seizures?

Evaluation: Evaluation includes the observation of the episodes by nurses and physicians, an electroencephalogram (EEG), and neuroimaging (head ultrasound, MRI). there are tests of blood chemistries, blood tests and lumbar puncture to determine if an infection is causing the seizures. ...Read more

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What are the tests for neonatal pneumonia?

See below: Normally would be the child's history, exam, chest x-ray, and a pulse ox. ...Read more

Dr. Jeffrey Satinover
1 Doctor shared a insight

Neonatal (Definition)

The term neonatal is generally used to describe events that occur with an infant within the first 30 days after birth. Some practitioners are looser with the definition & extend the ...Read more