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Doctor insights on: Connective Tissue Histology Slides

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Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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Histological section shows mainly decidualised endometrial tissue with hyperplastic glandular component specimen: uterine evacuation?

Histological section shows mainly decidualised endometrial tissue with hyperplastic glandular component

specimen: uterine evacuation?

Hyperplasia: The sample you describe is suggestive of overgrowth of tissue in the uterus due to irregular menstrual cycles. It is seen in women who go for > 6 months without bleeding and suggests overstimulation due to estrogen effect. If left untreated, it could lead to endometrial cancer. Still, it is very slow growing but needs to be monitored. ...Read more

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Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?

Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?

Marker not prognosis: CK7 and calretinin are used to verify that the tumor is mesothelial in origin (versus adenocarcinoma of the lung). It does not provide information about prognosis. Factors associated with pleural mesothelioma prognosis include: functional status, blood counts, histology (epithelial best vs fibrosarcomatous poorest), and tumor size (degree of involvement of pleural cavity). Several new trials. ...Read more

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What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"

What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"

Connective tissue: This is a constellation of disease affecting the supporting tissue throughout the body. It involves fat, cartilage,bone.there are different types with names such as Eleros Danlos , Marfans syndrome, Osteogensis imperfecta, they are all a result of gene dysfunction.ie are inheritable disorders. Most are fairly uncommon. The treatment varies depending on the specific areas involved ...Read more

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Please interpret this tissue biopsy. Fibrous pericardium with granulation tissue and fibrinous exudate. There is mild fibroplasia?

Please interpret this tissue biopsy. Fibrous pericardium with granulation tissue and fibrinous exudate.  There is mild fibroplasia?

Healing: The pericardium has been injured in some way, perhaps by surgery or there may be a healing infection. What is means most of all is there isn't tumor. ...Read more

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What is undifferentiated connective tissue disease?

What is undifferentiated connective tissue disease?

Type not clear: Undifferentiated connective-tissue disease (uctd) is a diagnosis applied to signs and symptoms that are consistent with a connective-tissue disease (ctd) but that do not fulfill the classification or diagnostic criteria for any one of the defined ctds such as (rheumatoid arthritis, lupus, etc..). ...Read more

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2specs: mesothelial-lined tissu w/endometrial-like stroma: 1 stain: cd10positiv in stroma; 2: calretinin&d2-40 postv in mesoth. Cells. Poss malignant?

2specs: mesothelial-lined tissu w/endometrial-like stroma: 1 stain: cd10positiv in stroma; 2: calretinin&d2-40 postv in mesoth. Cells. Poss malignant?

Tumor markers: An answer to your question isn't possible on-line. This needs to be discussed with the doctor ordering the test and the doctor interpreting the results. More details of you history and reasons for the testing are needed. It's not possible in this situation to tell you more. ...Read more

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What is fibrocollagenous tissue and adipose tissue?

Good question: Fibrocollagenous tissue is the connective tissue throughout our bodies that help maintain shape and function. Adipose tissue is fat. ...Read more

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Is fibromatosis a soft tissue sarcoma?

Is fibromatosis a soft tissue sarcoma?

Yes: Fibromatosis, while it doesn't have "sarcoma"in the name is actually a low-grade sarcoma. However, this only applies to cases occurring in the abdomen. Less commonly, these tumors can occur on the extremity. Cases of Palmar and Plantar fibromatosis are not aggressive and generally behave in a benign fashion. Have your sarcoma pathology checked by an expert david.stockman@orthopath.com ...Read more

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Biopsy results says Mid Secretory Endometrium. endometirial biopsy, are fragments of tan spongy soft tissue. 1.0x1,0x0.2. What does it mean?

Biopsy results says Mid Secretory Endometrium. endometirial biopsy, are fragments of tan spongy soft tissue. 1.0x1,0x0.2. What does it mean?

Endometrial biopsy: Your result indicate that at the time of your biopsy you were in the secretory or second phase of your cycle just before menstruation. Good things to know: no evidence of hyperplasia (pretumor growth) or malignancy. Sounds like a normal biopsy. ...Read more

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Whats mixed connective tissue disease?

Whats mixed connective tissue disease?

Labs can confuse.: The labs are just a fraction of what needed to get you better. Your history and physical exam will determine your treatment. Looking for which labs will delay and confuse. You need to develop a few paragraphs of all your issues and sit down with your doctor to put the pieces together. Began a wellness program and add in magnesium and acupuncture. ...Read more

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Section studied shows cystic spaced, the wall comprising of fibro collagenous tissue. The spaces show focal lining by multilayered oval to round cells?

Section studied shows cystic spaced, the wall comprising of fibro collagenous tissue. The spaces show focal lining by multilayered oval to round cells?

Speak with your MD: Please speak with your md about your concerns. Interpretation of a section needs to be in the context of the clinical situation and the reason for the biopsy. ...Read more

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How do connective tissues differ from epithelial tissues?

Epithelium: Epithelial tissues are covering layers whereas connective tissue is usually beneath the epithelium connecting other tissues, supportive structures. ...Read more

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WHAT DOES BENIGN ENDOMETRIUM WITH A PROLIFERATIVE PATTERN, GLANDULAR BREAKDOWN AND DIFFUSE STROMAL BREAKDOWN - SCANT BENIGN ENDOCERVICAL TISSUE MEAN?

WHAT DOES BENIGN ENDOMETRIUM WITH A PROLIFERATIVE PATTERN, GLANDULAR BREAKDOWN AND DIFFUSE STROMAL BREAKDOWN - SCANT BENIGN ENDOCERVICAL TISSUE MEAN?

No worries!: Benign is normal or "non-cancerous". Proliferative just means the cells are in the phase where they are dividing which is normal during the estrogen part of the cycle. Endocervical tissue is just cells that came from inside the cervix - these were also benign! All good news! ...Read more

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Could a fat lobule in breast come back as benign breast tissue on core biopsy pathology?

Could a fat lobule in breast come back as benign breast tissue on core biopsy pathology?

Breast biopsy: Fat is a normal benign part of the breast, so a biopsy of the breast could potentially only show fat. However, usually in breast biopsy the tissue Of interest is the fibrous stroma containing the breast lobules and ducts. If a pathology report says 'benign breast tissue' this would generally refer to benign stroma/ducts/lobules, and not just fat. ...Read more

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Can blood on thyroid fna biopsy sample slides cause distortion of cell groups?

Can blood on thyroid fna biopsy sample slides cause distortion of cell groups?

No: Blood products, cells and vessels are in every tissue in your body, so inevitably they will be present in biopsies. Special stains and other substances are used to differentiate different cells and tissues. ...Read more

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Weakly prolif. Endo. W foci of stromal and glandular breakdown. Rare lymphoid aggregates found in portions of biopsy in context to myxoid stroma seen ?

Weakly prolif. Endo. W foci of stromal and glandular breakdown. Rare lymphoid aggregates found in portions of biopsy in context to myxoid stroma seen ?

No ovulation: This is a description of endometrium that has been in the proliferative (growing or recovery) phase for too long. That is the phase which normally preceeds ovulation. After ovulation, the endometrium moves into the secretory phase during which an embryo can be received if pregnancy takes place; otherwise a normal menstrual phase (period) begins. Hormonal treatment may be necessary if out of order. ...Read more

Connective Tissue (Definition)

There are many types of connective tissue, but in general it is a mass of fibers and thick "goopy" fluids secreted by specialized cells. The body often uses connective tissue to help ...Read more