Doctor insights on:
Congenital Hepatic Fibrosis
Fibrosis = scarring: Inflammation of the liver, as almost anywhere else in the body, often heals with scarring. Lose enough functioning liver cells to scarring & you get cirrhosis. A fibrosis score is typically calculated during liver biopsy (& some fancier liver imagings) to calculate how much damage a chronically inflammed liver has sustained, & its risk of failing /decompensating. Then you need a liver transplant. ...Read more
None: Fibrosis is scarring as a result of inflammation and tissue damage. Eventually the scarring isolates pockets of hepatocytes (liver cells) so that they can no longer function appropriately. This is cirrhosis, and that creates problems resulting in symptoms. ...Read moreSee 1 more doctor answer
Liver biopsy = hepatic parenchyma showing moderate to severe chronic hepatitis w/bridging fibrosis &focal changes of early micronodular cirrhosis. Grade 3-4 stage 3-4. Can thyroid cause this? Or what?
Certainly: Cystic Fibrosis (CF) most common life-limiting genetic disorder of Caucasians, affecting approximately 30K people in the US.A, impacting mainly respiratory function. In recent years patients symptoms better controlled by genetic findings and better medications.Emotional & phys. development depend on severity, time in hospital, complications.Morb. & mort.factors afect emotional,cognitive behavior. ...Read more
As a carrier: Genetic carrier testing: more than 10 million americans are symptomless carriers of the defective CF gene. This blood test can help detect carriers, who could pass CF onto their children. To have cystic fibrosis, a child must inherit one copy of the defective CF gene from each parent. ...Read more
Yes: Yes it is possible. Presentation of cystic fibrosis varies greatly, and it is possible, depending on your specific mutation (and other factors) to present at a later age. In order to prevent late diagnoses, all states now have a newborn screen in place for cystic fibrosis. ...Read moreSee 1 more doctor answer
I have family members with cystic fibrosis. Is it possible to start show the symptoms in my 20's?
What are the chances of a child getting cystic fibrosis among the different racial groups in the u.S.?
Overall 1/3700: Acording to the CF foundation: the overall birth prevalence is 1/3700 . It can occur in any race, however the greatest incidence is in caucasians of northern european descent, being 1/2500. The other major groups affected are hispanics 1/13500, african americans 1/15000. More than 10 million of us carry one part of the defective gene, but to have the disease you must have a copy from both parents. ...Read moreSee 1 more doctor answer
Retroperitoneal Fibr: Retroperitoneal fibrosis is a rare disease, often idiopathic, but drugs, infections malignancies, prior surgeries, radiation therapy, smoking, and asbestos exposure have been implicated. . It is characterized by the presence of inflammatory and fibrous retroperitoneal tissue that often encases the ureters & other abdominal organs. Symptoms include back or flank pain, and decreased kidney function ...Read more
Depends on genes: The risk of acquiring cystic fibrosis (CF) depends on whether the parents of a child are carriers for the gene. It is estimated that about 1 in 20 americans are carriers of the CF gene. In order for a child to acquire the disease, both parents must be carriers. If both parents are carriers, there is then a 25% chance that the child will acquire the disease. ...Read moreSee 1 more doctor answer
Cough, poor growth: Common symptoms of cystic fibrosis include cough, wheeze, recurrent lung infections, poor growth, foul smelling stools, salty sweat, clubbing, and rectal prolapse. The more symptoms the greater the chance of having cystic fibrosis. Most infants today are diagnosed by newborn screening for CF before they develop any symptoms and early therapy can minimize disease symptoms. ...Read more