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Doctor insights on: Congenital Central Diabetes Insipidus

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Dr. Luis Gonzalez-mendoza
251 doctors shared insights

Diabetes Insipidus (Definition)

A condition in which your pituitary gland does not make the ADH hormone, and you have to drink and urinate constantly. Many with this condition carry water with them at all ...Read more


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Could chiari malformation cause pituitary problems or diabetes insipidus?

Could chiari malformation cause pituitary problems or diabetes insipidus?

Very unusual: 7 cases of hypopituitarism all having a history of breech delivery, asphyxia at birth, and syringomyelia. A small pituitary gland was found on MRI or CT in six cases, invisible pituitary stalk on MRI in five cases, and type 1 Arnold-Chiari malformation in six cases. A constellation of these abnormalities best explained by traction of brain and spinal cord.Not usually with uncomplicated Chiari 1. ...Read more

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Is nephrogenic diabetes insipidus similiar to children's diabetes or not?

Is nephrogenic diabetes insipidus similiar to children's diabetes or not?

Imprecise question: Diabetes insipitus is decreased production or effect of vasopressin- nephrogenic is where it's effect reduced because of a kidney issue diabetes mellitus is a high sugar problem due to immune destruction of cells making Insulin in pancreas they are different disease states. ...Read more

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How are diabetes insipidus and diabetes mellitus different?

How are diabetes insipidus and diabetes mellitus different?

Very different: Diabetes mellitus is the typical "diabetes" that we are familiar with. It's caused by an Insulin problem (too little or just not working well (resistance)) causing elevation in blood sugar. Diabetes insipidus is a water problem characterized by lots of urination and high sodium level. It's caused by an ADH (vasopressin) (antidiuretic hormone) problem (too little or just not working well). ...Read more

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Pathophysiology of diabetes mellitus in pregnancy?

Pathophysiology of diabetes mellitus in pregnancy?

Glucose intolerance: The short paragraph here doesn't give me alot to explain this, but basically pregnancy is a relatively glucose resistant state and the more times you are pregnant, the more likely you get gestational diabetes. There are alterations in Insulin levels and Insulin resistance during the pregnancy. The typical american diet of high sugar processed foods doesn't help. ...Read more

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Could diabetes insipidus lead to seizures?

Could diabetes insipidus lead to seizures?

Seizures and DI: DI could be related to seizures, at least because there are changes in electrolytes in cases of DI, and electrolyte abnormalities often cause seizures. Electrolytes include sodium, potassium and calcium. ...Read more

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What is diabetes insipidus?

What is diabetes insipidus?

Two types: Either antidiuretic hormone (ADH (vasopressin)) is not being made in the posterior part of the pituitary or ADH (vasopressin) is being made, but the kidney lacks the receptor to which ADH (vasopressin) is bound in order to work to preserve water from leaving the body in excess. ...Read more

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Possible complications of diabetes mellitus?

Possible complications of diabetes mellitus?

Many: Diabetes is a multi system disease. Therefore it can affect almost any part of your body. You name, i can tie a potential diabetic complication. I'll quickly go head to toe. 1: brain - stroke 2: eyes: blindness 3: heart: coronary disease 4: gi: gastroparesis (slowing) 5: genito/urinary: erectile dysfunction 6: legs: poor circulation this is just a small sampling! ...Read more

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Can symptoms of diabetes insipidus disappear?

Can symptoms of diabetes insipidus disappear?

If the cause disappe: The degree of recovery is largely dependent on the underlying cause of the disease. Complete resolution of symptoms may not be seen in individuals with severe disease. Chronic diabetes insipidus, although inconvenient, is not usually a dire medical condition. When properly treated, diabetes insipidus itself does not reduce life expectancy. The prognosis, therefore, depends on the underlying diseas. ...Read more

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Are diabetes, thyroid diseases, child births common causes of obesity?

Are diabetes, thyroid diseases, child births  common causes of obesity?

Obesity: Obesity is the main cause of diabetes type 2. Thyroid disease can cause weight gain or weight loss, depending on what it's doing. Obesity does not cause child births. ...Read more

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How does diabetes mellitus causes placental insufficiency ?

How does diabetes mellitus causes placental insufficiency ?

Blood flow: Diabetes is a glucose control disorder that affects blood vessels. If diabetes is well controlled then the injury to blood vessels is negligible. When blood vessels are narrowed or compromised-then the fetus receives less blood flow and nutrients which may be associated with newborn problems. ...Read more

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What hormone imbalance leads to the type II diabetes mellitus disorder?

What hormone imbalance leads to the type II diabetes mellitus disorder?

It is a problem of y: Yoru pancreas secreting enough Insulin when you need it. The types of diabetes i and ii also affect your bodies response to sugar intake (or carb). Basically you need to see a doctor when you have diabetes. You also need to get a glucose meter so you can monitor it yourself. That you can buy over the counter. In general fasting (early morning) glucose is one goal.. And then over the day... ...Read more

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Is central diabetes insipidus related to adrenal insuffiency? Im having an ACTH test to check adrenal function.

Is central diabetes insipidus related to adrenal insuffiency? Im having an ACTH test to check adrenal function.

Can be: Hi. If you have Addison's (skin, crease, gum, and scar darkening, malaise, nausea, dizziness, vital signs abnormalities, electrolyte abnormalities, etc), your ACTH will be very high. Addison's is most commonly an autoimmune disease. At least a subset of idiopathic central DI appears to be autoimmune in nature, and the risk of that goes up with other autoimmune diseases. If real, you got 2 rare 1's ...Read more

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Other causes of polydypsia and polyuria than diabetes insipidus and psychogenic?

Other causes of polydypsia and polyuria than diabetes insipidus and psychogenic?

Classic causes: But many patients have taken to consuming large amounts of water due to perception that this is valuable for their health. An internist is ideal to figure this out. ...Read more

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Besides head injury, pregancy, surgery,or pituitary tumor, what can cause one to have transient central diabetes insipidus? autoimmune?

Besides head injury, pregancy, surgery,or pituitary tumor, what can cause one to have transient central diabetes insipidus? autoimmune?

Hard to say: Hi. I'd like to see the evidence for transient DI. Most autoimmune DI (for which there is no clinical lab test...yet) is not transient as far as we know, although that would be high on the list of suspects for a transient DI, in my opinion, having excluded the other causes you mention. Consider yourself fortunate if it's transient! Happy 2015! ...Read more

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What are the predisposing factors in gestational diabetes mellitus?

Weight/Genetics: Diabetes often runs in families, and 70% of women with gestational diabetes will get diabetes later in life. Major risks include obesity (body mass index >30), older maternal age, past history of gestational diabetes, and ethnicity (african americans, native americans, south asia/india, hispanic, pacific islanders, and some from the caribbean). Be sure to get re-tested 6-12 weeks after delivery. ...Read more

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Dx'd w/partial idiopathic central diabetes insipidus 20yrs ago by H20deprivation test. Put on DDAVP (desmopressin). No longer needed DDAVP (desmopressin) after 2 yrs.Sx better.Why?

Dx'd w/partial idiopathic central diabetes insipidus 20yrs ago by H20deprivation test. Put on DDAVP (desmopressin). No longer needed DDAVP (desmopressin) after 2 yrs.Sx better.Why?

Central DI: Hard to answer. It was called "idiopathic", meaning no clear cause. In a 13 yr old, the causes could include a tumor, certain medications, trauma/surgery, meningitis, etc. It is possible that something happened back then but then resolved. Is it possible that you now still have partial DI? Under usual conditions, don't need DDAVP, (desmopressin) but under water stress you may. See your Endocrinologist. ...Read more

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Can partial central diabetes insipidus go away or improve? After 2yrs needing ddavp (desmopressin) to control, eventually urine started to concentrate without it.

Can partial central diabetes insipidus go away or improve? After 2yrs needing ddavp (desmopressin) to control, eventually urine started to concentrate without it.

I have seen: one patient in which this happened, but it is very uncommon if the diagnosis is made correctly. Check w/your doctor. ...Read more

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Is central diabetes insipidus related to adrenal insuffiency? Im having an ACTH test to check adrenal function.

Can be: Hi. If you have Addison's (skin, crease, gum, and scar darkening, malaise, nausea, dizziness, vital signs abnormalities, electrolyte abnormalities, etc), your ACTH will be very high. Addison's is most commonly an autoimmune disease. At least a subset of idiopathic central DI appears to be autoimmune in nature, and the risk of that goes up with other autoimmune diseases. If real, you got 2 rare 1's ...Read more

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Besides head injury, pregancy, surgery,or pituitary tumor, what can cause one to have transient central diabetes insipidus? autoimmune?

Hard to say: Hi. I'd like to see the evidence for transient DI. Most autoimmune DI (for which there is no clinical lab test...yet) is not transient as far as we know, although that would be high on the list of suspects for a transient DI, in my opinion, having excluded the other causes you mention. Consider yourself fortunate if it's transient! Happy 2015! ...Read more

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Can symptoms of diabetes insipidus disappear?

If the cause disappe: The degree of recovery is largely dependent on the underlying cause of the disease. Complete resolution of symptoms may not be seen in individuals with severe disease. Chronic diabetes insipidus, although inconvenient, is not usually a dire medical condition. When properly treated, diabetes insipidus itself does not reduce life expectancy. The prognosis, therefore, depends on the underlying diseas. ...Read more

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Foods that help people with diabetes insipidus?

It depeds on reason: One component of effective management of nephrogenic diabetes insipidus is the low sodium diet. Restricted sodium intake limits renal solute load and permits full effectiveness of chorothiazide. The usual sodium intake for persons in the us is about 5000 mg/day. From a medical perspective, the low sodium restriction for treatment of hypertension is 2400 mg/day. ...Read more

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How often is diabetes insipidus from lithium reversible?

How often is diabetes insipidus from lithium reversible?

Early = better: I can't tell you how often, but I can strongly urge you to see your provider ASAP to stop taking lithium and if this is a fairly new problem, it is more likely to reverse, but it can take time. The damage done is to the kidney - be sure to stay well hydrated and make an appointment. I hope you've caught it in time - good thinking to ask! Best wishes for a good result! ...Read more

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What is the difference between diabetes insipidus and mellitus?

What is the difference between diabetes insipidus and  mellitus?

Unrelated conditions: Diabetes mellitus (dm) is a condition of excessively high sugars which can cause one to void large amounts of urine frequently. Type 1 dm is caused by pancreatic failure so Insulin is required. Type 2 dm is resistance to Insulin or inefficient use. Diabetes insipidus is voiding large amounts of urine frequently due to either kidney or brain disorder, both unrelated to sugar & insulin. ...Read more

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Could symptoms of diabetes insipidus disappear and then return, why?

YES: Post brain surgery or trauma or irradiation or chemotherapy, can cause transient diabetes insipidus and siadh. Treatment is indicated during the transient phase. ...Read more

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How does diabetes insipidus affect lifespan?

How does diabetes insipidus affect lifespan?

Little: Diabetes insipidus is caused by the inability of the kidneys to conserve water, which leads to frequent urination and pronounced thirst.The outcome depends on the underlying disorder. If treated, diabetes insipidus does not cause severe problems or reduce life expectancy. ...Read more

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Can you tell me how hypernatremia occur in diabetes insipidus?

Can you tell me how hypernatremia occur in diabetes insipidus?

ADH (vasopressin): Hypernatremia occurs in diabetes insipidus secondary due to the lack of anti diuretic hormone (ADH) effect in the kidney, resulting in decreased free water absorption thus creating a higher sodium. ...Read more

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Why are thiazide diuretics used in diabetes insipidus?

Why are thiazide diuretics used in diabetes insipidus?

Paradox: Thiazides paradoxically reduce the amount of urine the kidneys produce in the nephrogenic form of di. Thiazides are not used in the central form. ...Read more

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What is the fluid deprivation test for diabetes insipidus?

What is the fluid deprivation test for diabetes insipidus?

Vasopressin test.: This is a dehydration test for diabetes insipidus. First, fluid is withheld until urine osmolality is stable. Then 5 u of vasopressin is given by subcutaneous injection. The urine and plasma osmolality/concentration is measures before and one hour after the injection. Argenine vasopressin or avp given to these patients causes a >9% rise in urine osmolality. In normal patients, it is <9%. ...Read more

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How are diabetes insipidus and diabetes mellitus different?

Very different: Diabetes mellitus is the typical "diabetes" that we are familiar with. It's caused by an Insulin problem (too little or just not working well (resistance)) causing elevation in blood sugar. Diabetes insipidus is a water problem characterized by lots of urination and high sodium level. It's caused by an ADH (vasopressin) (antidiuretic hormone) problem (too little or just not working well). ...Read more

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What types of treatments are available for diabetes insipidus?

What types of treatments are available for diabetes insipidus?

Depends: There are two types of diabetes insipidus (di). In central di the patient is not making enough of a hormone to reabsorb water in the kidneys, and in nephrogenic di the kidneys don't respond to the hormone. Central di is treated with desmopressin. Nephrogenic di is treated with thiazide diuretics. Both treatments will prevent excessive thirst and decrease the amount of urine. Need to find the cause. ...Read more

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Why does hypernatremia occur in patients with diabetes insipidus?

Why does hypernatremia occur in patients with diabetes insipidus?

Dehydration: If you have diabetes insipidus and don't take in enough water to balance what you urinate out, hypernatremia can result. Ddavp (desmopressin) can usually return your life to normal. Talk w/your doctor. ...Read more

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Is there a connection between celiac disease and diabetes insipidus?

Is there a connection between celiac disease and diabetes insipidus?

No: None that I am aware of and I could not find anything significant in a quick search. Type 1 diabetes and celiac are more common together, but not diabetes insipidus. ...Read more

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Dr. Quang Nguyen
3,331 doctors shared insights

Diabetes (Definition)

A group of diseases that result in too much sugar in the ...Read more