Doctor insights on:
Congenital Central Diabetes Insipidus
Dx'd w/partial idiopathic central diabetes insipidus 20yrs ago by H20deprivation test. Put on DDAVP (desmopressin). No longer needed DDAVP (desmopressin) after 2 yrs.Sx better.Why?
Central DI: Hard to answer. It was called "idiopathic", meaning no clear cause. In a 13 yr old, the causes could include a tumor, certain medications, trauma/surgery, meningitis, etc. It is possible that something happened back then but then resolved. Is it possible that you now still have partial DI? Under usual conditions, don't need DDAVP, (desmopressin) but under water stress you may. See your Endocrinologist. ...Read more
Diabetes is a disease of increased blood glucose levels. Glucose is a type of sugar that comes from the intake of food. Insulin is a type of hormone that removes the glucose from the blood and moves it into the cells to provide them with energy. There are two different types of diabetes: type 1 and type 2. Type 1 diabetes is when the body does not make any insulin. Therefore, glucose stays inside the blood and does not move into the cells. Type 2 diabetes, which is commonly associated with obesity, is when the body is either resistant to the effects of insulin or when the body does not produce enough insulin. Increased levels of glucose in the body causes severe damage to the ...Read more
Can partial central diabetes insipidus go away or improve? After 2yrs needing ddavp (desmopressin) to control, eventually urine started to concentrate without it.
I have seen: one patient in which this happened, but it is very uncommon if the diagnosis is made correctly. Check w/your doctor. ...Read more
Is central diabetes insipidus related to adrenal insuffiency? Im having an ACTH test to check adrenal function.
Can be: Hi. If you have Addison's (skin, crease, gum, and scar darkening, malaise, nausea, dizziness, vital signs abnormalities, electrolyte abnormalities, etc), your ACTH will be very high. Addison's is most commonly an autoimmune disease. At least a subset of idiopathic central DI appears to be autoimmune in nature, and the risk of that goes up with other autoimmune diseases. If real, you got 2 rare 1's ...Read more
Besides head injury, pregancy, surgery,or pituitary tumor, what can cause one to have transient central diabetes insipidus? autoimmune?
Hard to say: Hi. I'd like to see the evidence for transient DI. Most autoimmune DI (for which there is no clinical lab test...yet) is not transient as far as we know, although that would be high on the list of suspects for a transient DI, in my opinion, having excluded the other causes you mention. Consider yourself fortunate if it's transient! Happy 2015! ...Read more
If the cause disappe: The degree of recovery is largely dependent on the underlying cause of the disease. Complete resolution of symptoms may not be seen in individuals with severe disease. Chronic diabetes insipidus, although inconvenient, is not usually a dire medical condition. When properly treated, diabetes insipidus itself does not reduce life expectancy. The prognosis, therefore, depends on the underlying diseas. ...Read more
It depeds on reason: One component of effective management of nephrogenic diabetes insipidus is the low sodium diet. Restricted sodium intake limits renal solute load and permits full effectiveness of chorothiazide. The usual sodium intake for persons in the us is about 5000 mg/day. From a medical perspective, the low sodium restriction for treatment of hypertension is 2400 mg/day. ...Read more
Early = better: I can't tell you how often, but I can strongly urge you to see your provider ASAP to stop taking lithium and if this is a fairly new problem, it is more likely to reverse, but it can take time. The damage done is to the kidney - be sure to stay well hydrated and make an appointment. I hope you've caught it in time - good thinking to ask! Best wishes for a good result! ...Read more
Unrelated conditions: Diabetes mellitus (dm) is a condition of excessively high sugars which can cause one to void large amounts of urine frequently. Type 1 dm is caused by pancreatic failure so Insulin is required. Type 2 dm is resistance to Insulin or inefficient use. Diabetes insipidus is voiding large amounts of urine frequently due to either kidney or brain disorder, both unrelated to sugar & insulin. ...Read more
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