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Doctor insights on: Complications Of Sickle Cell Anemia

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Describe symptoms of sickle cell anemia trait?

Describe symptoms of sickle cell anemia trait?

Usually none.: Patients with sca trait usually have no symptoms. If they are in an environment where oxygen is low, like high altitude, it is possible to have a pain crisis like sca patients get, but it is quite rare. ...Read more

Dr. James Ball
355 doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more


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Is malaria and sickle cell anemia related?

Is malaria and sickle cell anemia related?

Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read more

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What are symptoms of sickle cell anemia crisis?

What are symptoms of sickle cell anemia crisis?

Pain.: When red cells sickle, they become rigid and block the flow of blood. If this happens in muscle or bone, the result is pain. In the lung it's pain and shortness of breath. In the brain, it can cause a stroke. Any organ can be effected. A painful crisis happens when blood flow is interrupted. They are episodic and unpredictable. ...Read more

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Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more

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Could carriers of sickle cell anemia develop symptoms.?

Could carriers of sickle cell anemia develop symptoms.?

Sickle cell trait: Sickle trait means one copy of hemoglobin carries the mutation for sickle cell disease and the other copy is unaffected. Most people with sickle trait are unaffected by this. For athletes with sickle trait, it is essential to keep well hydrated. See http://www.Cdc.Gov/ncbddd/sicklecell/traits.Html for good recommendations. ...Read more

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What are some of the splenic complications of sickle cell anaemia?

What are some of the splenic complications of sickle cell anaemia?

See below: Splenic infarction (cut off of blood supply to the spleen) can occur (this is painful!) when patients are kids. As patients enter adulthood, the spleen can eventually disappear. This can make patient more suspectible to infections that would not occur in patients with functioning spleens. ...Read more

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Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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What chromosome carries the gene for sickle cell anemia?

What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

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What are the symptoms of sickle cell disease- hydroxyurea?

What are the symptoms of sickle cell disease- hydroxyurea?

Well tolerated drug.: Hydrea (hydroxyurea) is a chemotherapy like drug that can help prevent painful crises in patients with sickle cell disease. It is well tolerated for the most part. There can be fatigue, mouth sores and loose stools. It will routinely lower the white blood cell count and platelets, but not to dangerous levels. Hemoglobin may actually improve. There is ? Of leukemia risk in other diseases, but not in scd. ...Read more

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What are the effects of sickle cell anemia?

Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more

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What are the types of gene defects in sickle cell anemia?

What are the types of gene defects in sickle cell anemia?

Several: There are several genetic defects that lead to sickle cell anemia. They all lead to a change in the 6th Amino Acid in the beta-globin chain in which valine is substituted for glutamic acid. At least 5 different dna mutations have been identified that all lead to the same Amino Acid substitution, and thus, sickle cell anemia. ...Read more

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What are the symptoms of sickle cell trait vs anemia?

What are the symptoms of sickle cell trait vs anemia?

Trait is asymptomatc: A person with as hemoglobin (sickle cell trait is almost always asymptomatic themselves but can pass the mutated gene onto their children. A person with sshemoglobin(sickle cell anemia) is also sometimes asymptomatic, but often develops some symptoms including: anemia, fatigue, pain, slow growth, increased incidence of infection crises, etc. ...Read more

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What conditions are associated with sickle cell anemia?

What conditions are associated with sickle cell anemia?

There are many: You are predisposed to acute chest crises, painful crises, stroke, lung hypertension, kidney dysfunction, and many many others. ...Read more

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Can sickle cell anemia be fatal?

Can sickle cell anemia be fatal?

Yes: Individuals with sickle cell anemia are at high risk to develop invasive bacterial infections, e.g., meningitis and bacteremia, especially by pneumococcus. Penicillin prophylaxis, immunization, and prompt medical attention for febrile illness have greatly reduced fatality from serious infection. ...Read more

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What are similar sickle cell and aplastic anemia symptoms?

What are similar sickle cell and aplastic anemia symptoms?

Anemia: The only thing similar is that both have anemia ( decrease level of hemoglobin ). That is all. Sickle cell anemia and aplastic anemia are completely different disorders. Each has different pathogenesis, different clinical manifestation/symptoms, etiologies, treatments etc. ...Read more

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What causes sickle cell anemia besides malaria?

What causes sickle cell anemia besides malaria?

Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia protects carriers from malaria infections, which could be advantageous in certain parts of the world. Malaria does not cause sickle cell anemia. ...Read more

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What's the life expectancy of someone with sickle cell anemia?

Shortened. : Depends on the complications experienced as a child. Those with numerous complications will love shorter lives than those without complications. Those without complications can live into their 60s the average lifespan of someone with sickle cell is probably in the mid to late 40s we are still trying to understand why some people have so many troubles and others do not. ...Read more

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Can the basic genetic defect of sickle cell anemia be treated?

Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficult and dangerous procedure that can lead to significant complications and death. This is why it is not routinely used to treat sickle cell anemia. Research is ongoing in attempts to have people with sickle cell anemia make normal blood cells. ...Read more

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Is sickle cell anemia contagious?

No: Sickle cell anemia is not an infection - thus it is not contagious. It is a genetic disease and so, it is hereditary. ...Read more

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Dr. Steven Ginsberg
1,283 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more