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Doctor insights on: Complement Total Ch50

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What is complement total (ch50) elevated over 60 mean? Any significance?

What is complement total (ch50) elevated over 60 mean? Any significance?

Basically no: It's more worrisome if it's low. Lab reference ranges are set so that maybe 5% of healthies fall outside on either end. Don't worry. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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My complement Total (CH50) was elevated in July. Four months later, it was low (33). What can cause this?

My complement Total (CH50) was elevated in July.  Four months later, it was low (33).  What can cause this?

It fluctuates: These levels vary tremendously with minor illness, even little viral stuff that you don't know you have. And reference ranges are set so that a few percent of healthies fall outside on either end. These labs are only small pieces in diagnostic puzzles. ...Read more

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Ana titer 1:80 — positive vitamin d — 17 complement, total >60 ch50 Any idea what I might have? I am scared that it is cancer.

Ana titer 1:80 — positive
vitamin d — 17
complement, total >60
ch50

Any idea what I might have?  I am scared that it is cancer.

Nothing to suggest..: Cancer. You are vitamin d deficient! as are 1/2 of my patients. Your ANA titerbis insignificant. Please, nothing would suggest cancer by these tests! ...Read more

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What to do if I have high levels of total complement (ch50) and c-reactive protein. What does that mean?

Need to determine: Cause of elevation. Both of these are markers of inflammation. You should see your doctor to determine what may be causing inflammation. It does not have to be an infection. It is not feasible to be more helpful in this forum. ...Read more

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Could rosacea and ocular rosacea cause an elevated Total Complement (CH50)? I am healthy, very active, feel great.

Could rosacea and ocular rosacea cause an elevated Total Complement (CH50)?
I am healthy, very active, feel great.

Ocular rosea: Roscea can be an autoimmune disorder and as such can have elevated immune markers .Alternatively could be lupus. Did they check other markers like dsDNA Sm antibody? F/u /w dermatology


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834698/ ...Read more

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Crp of 8.4 and total complement of >63 are these elevated or just on the high end of normal?

Probably normal.: These numbers are non-specific. Unless you have a specific syndrome or symptoms these numbers really mean nothing. ...Read more

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What means very high CH50 complement? Mine is 277 CAE,C3 and C4 normal. Ref ranges for lab are only greater than 60,but I read high could be pathologis

How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. ...Read more

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I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?... Or would low C3 or C4 show up on ch50 test?

Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?... Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low C3 and C4 levels suggest activation of the classical pathway.
Low C3 and normal C4 levels suggest activation of the alternate pathway.
C4 could be low with a normal ch50. ...Read more

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Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?

Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?

Not enough info: Anas must always be evaluated in the context of the entire clinical picture. You have given no information about the clinical problem and why you are taking methotrexate. The ANA patterns can change from test to test. The patterns only mean something if they fit the clinical symptoms. ...Read more

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Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?

Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?

Abnormal labs: A positive ANA does not mean you have a specific disease. The high complement level is a good sign — low is not good. I recommend seeing a rheumatologist for further evaluation. ...Read more

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Crp 2.73, ESR 22, ANA + speckled 1:40, complement ch50 is >60. 15 years of fatigue/malaise, headaches, ibs, aches and pains. Any correlation?

Crp 2.73, ESR 22, ANA + speckled 1:40, complement ch50 is >60. 15 years of fatigue/malaise, headaches, ibs, aches and pains. Any correlation?

Chronic Lyme?: Have you been tested properly for chronic Lyme? Consider iSpot Lyme test, not conventional western blot. ...Read more

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If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.

If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.

Lab data: Without placing values in a clinical context with full history, exam and all data it is pointless to speculate. You need to be evaluated by a physician and if the one you are seeing cannot provide answers, get a second opinion. Try seeing an infectious diseases expert. ...Read more

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What is complement c3?

What is complement c3?

Complement C3: Complement C3 is a blood test that measures the activity of a certain protein that is part of the complement system. The complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. This test is usually elevated in immune diseases or infections. ...Read more

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What does it mean by complement activation?

Complement : Is a series of immune proteins that are usually cause a "chain reaction" of events that lead to inflammation and when activated by infection, hormonal changes, etc., it will cause this chain reaction to start aka complement activation. ...Read more

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What does the complement receptor type 1 do?

CR1: There is some controversy here, but it seems to mainly act through binding of C1q upon forming complexes with antibody in the bloodstream. CR1 is highly expressed on red blood cells, so these cells carry immune complexes away from the site of attachment to the spleen where the immune complexes are destroyed. An "immune complex" is a cluster of antibodies and there antigen targets (like a virus). ...Read more

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How is complement involved in immune responses?

Complement: The complement system helps antibodies and phagocytic cells clear pathogens. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. Generally synthesized by the liver. Stimulated by one of several triggers.... Etc. ...Read more

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I am feeling like a failure, complementing suicide each day?

I am feeling like a failure, complementing suicide each day?

Time 2 get support: You can find a local psychologist here http://locator. Apa. Org/. Often medication can help during a time like this. Your psychologist or physician can recommend a psychiatrist, if you’re interested in exploring medication options. If you feel like you are in crisis, please go to the nearest er or call 911. Suicide hotline 800-273-talk. ...Read more

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Can different types of health practitioners complement each other?

Should be a team: For many patients with multiple or complex medical problems several specialist may be indicated to work with the patient and their primary care physician for optimal diagnosis and treatment. Physicians of different specialties most certainly can and should complement each other as long as they stay within the scope of their expertise. ...Read more

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Complement C4 is .12 (normal is .14 -.54) is it worth getting repeated.

Complement C4 is .12 (normal is .14 -.54) is it worth getting repeated.

Depends: Complement C4 being low could indicate an issue with activation of the complement system such as after infection. It could also be related to liver disease, genetic deficiency of complement, vasculitis, lupus, or even could just be a low-normal value for you. So I would repeat testing only if you have other medical concerns that are currently being evaluated. ...Read more

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What is the average weight to complement a person with the height of 5'9"?

What is the average weight to complement a person with the height of 5'9"?

155 pounds!: Good morning, at 5'9 you are at the 50th percentile (average) height for us men; the corresponding weight for will be 155 pounds. ...Read more

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What food to eat before/after training or competing to help me complement my exercise and lose weight?

What food to eat before/after training or competing to help me complement my exercise and lose weight?

Chocolate milk after: For average person, what to eat, whether before/after exercise, and at what time of day (AM/PM) is really immaterial. Instead, we should be just focusing on exercising. Period. Unless we're an elite athlete, in which case, our coach will set up strict programs & times for both nutrition & exercise. But if you want to obsess over this, check out menshealth.com, mensfitness.com & mensjournal.com. ...Read more

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I am feeling like a failure, complementing suicide each day due to feeling worthless, what should I do?

I am feeling like a failure, complementing suicide each day due to feeling worthless, what should I do?

DON'T DO IT: One of the few statistics that is the same today as when I was in med school long ago is that among young adults in reasonably good physical health who attempted suicide and failed, ninety-nine percent were glad, one year later, that they failed. There are things you can learn (new skills, new ways of thinking) that will make all the difference. Key is to find a competent guide / therapist. ...Read more

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What foods complement each other well nutritionally?

What foods complement each other well nutritionally?

Whole foods: If you want the best nutritionally rich diet, stick with whole foods, fruits, vegetables, nuts, seeds, and grain. Avoid animal protein and dairy. ...Read more

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What is the definition or description of: complement?

Complement System: The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by natural "tick-over" of C3. ...Read more

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Can you tell me about immunobiology — complement cascade?

Textbook: This is a subject which should be studied with a textbook. Briefly complement is a system whereby the body kills off offenders. However, there are check-and-balance system to make sure that it does not go too far leading to unwanted tissue damages. ...Read more