Doctor insights on:
Complement Total Ch50
Basically no: It's more worrisome if it's low. Lab reference ranges are set so that maybe 5% of healthies fall outside on either end. Don't worry. ...Read more
The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more
My complement Total (CH50) was elevated in July. Four months later, it was low (33). What can cause this?
It fluctuates: These levels vary tremendously with minor illness, even little viral stuff that you don't know you have. And reference ranges are set so that a few percent of healthies fall outside on either end. These labs are only small pieces in diagnostic puzzles. ...Read more
What can cause the Sedimentation Rate-Westergren — 70; Complement C4, Serum — 53; Immunoglobulin M, Qn, Serum — 36; Complement, Total (Ch50) >63?
Ana titer 1:80 — positive
vitamin d — 17
complement, total >60
Any idea what I might have? I am scared that it is cancer.
Diagnosed with high levels of total complement (ch50) and c-reactive protein. What does that mean?
Inflammation: It means that you have some sort of inflammatory process going on inside of the body presently. ...Read more
Could rosacea and ocular rosacea cause an elevated Total Complement (CH50)?
I am healthy, very active, feel great.
Probably normal.: These numbers are non-specific. Unless you have a specific syndrome or symptoms these numbers really mean nothing. ...Read more
What means very high CH50 complement? Mine is 277 CAE,C3 and C4 normal. Ref ranges for lab are only greater than 60,but I read high could be pathologis
How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. ...Read more
I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal(57 u/ml)-(all are serum tests)-what are the possible causes?
Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more
Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?... Or would low C3 or C4 show up on ch50 test?
Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low C3 and C4 levels suggest activation of the classical pathway.
Low C3 and normal C4 levels suggest activation of the alternate pathway.
C4 could be low with a normal ch50. ...Read more
Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?
Not enough info: Anas must always be evaluated in the context of the entire clinical picture. You have given no information about the clinical problem and why you are taking methotrexate. The ANA patterns can change from test to test. The patterns only mean something if they fit the clinical symptoms. ...Read more
Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?
Could my severe vitamin d deficiency be the cause of my extremely high complement ch50 level? C3 and C4 are normal.
No: I'd ignore the high ch50 levels. This is a lab test that's hard to do and even harder to interpret. ...Read more
Rheumatologist said I have low bence-jones protein in urine. Complement c3, C4 are normal. Ch50 high. He said don't worry. Should I go to oncologist?
Crp 2.73, ESR 22, ANA + speckled 1:40, complement ch50 is >60. 15 years of fatigue/malaise, headaches, ibs, aches and pains. Any correlation?
Chronic Lyme?: Have you been tested properly for chronic Lyme? Consider iSpot Lyme test, not conventional western blot. ...Read more
If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.
Lab data: Without placing values in a clinical context with full history, exam and all data it is pointless to speculate. You need to be evaluated by a physician and if the one you are seeing cannot provide answers, get a second opinion. Try seeing an infectious diseases expert. ...Read more
Complement C3: Complement C3 is a blood test that measures the activity of a certain protein that is part of the complement system. The complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. This test is usually elevated in immune diseases or infections. ...Read more
CR1: There is some controversy here, but it seems to mainly act through binding of C1q upon forming complexes with antibody in the bloodstream. CR1 is highly expressed on red blood cells, so these cells carry immune complexes away from the site of attachment to the spleen where the immune complexes are destroyed. An "immune complex" is a cluster of antibodies and there antigen targets (like a virus). ...Read more
Complement: The complement system helps antibodies and phagocytic cells clear pathogens. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. Generally synthesized by the liver. Stimulated by one of several triggers.... Etc. ...Read more
Time 2 get support: You can find a local psychologist here http://locator. Apa. Org/. Often medication can help during a time like this. Your psychologist or physician can recommend a psychiatrist, if youre interested in exploring medication options. If you feel like you are in crisis, please go to the nearest er or call 911. Suicide hotline 800-273-talk. ...Read more
Should be a team: For many patients with multiple or complex medical problems several specialist may be indicated to work with the patient and their primary care physician for optimal diagnosis and treatment. Physicians of different specialties most certainly can and should complement each other as long as they stay within the scope of their expertise. ...Read more
Depends: Complement C4 being low could indicate an issue with activation of the complement system such as after infection. It could also be related to liver disease, genetic deficiency of complement, vasculitis, lupus, or even could just be a low-normal value for you. So I would repeat testing only if you have other medical concerns that are currently being evaluated. ...Read more
What food to eat before/after training or competing to help me complement my exercise and lose weight?
Chocolate milk after: For average person, what to eat, whether before/after exercise, and at what time of day (AM/PM) is really immaterial. Instead, we should be just focusing on exercising. Period. Unless we're an elite athlete, in which case, our coach will set up strict programs & times for both nutrition & exercise. But if you want to obsess over this, check out menshealth.com, mensfitness.com & mensjournal.com. ...Read more
I am feeling like a failure, complementing suicide each day due to feeling worthless, what should I do?
DON'T DO IT: One of the few statistics that is the same today as when I was in med school long ago is that among young adults in reasonably good physical health who attempted suicide and failed, ninety-nine percent were glad, one year later, that they failed. There are things you can learn (new skills, new ways of thinking) that will make all the difference. Key is to find a competent guide / therapist. ...Read more
Complement System: The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by natural "tick-over" of C3. ...Read more
Textbook: This is a subject which should be studied with a textbook. Briefly complement is a system whereby the body kills off offenders. However, there are check-and-balance system to make sure that it does not go too far leading to unwanted tissue damages. ...Read more