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Doctor insights on: Complement Panel

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What foods complement each other well nutritionally?

What foods complement each other well nutritionally?

Whole foods: If you want the best nutritionally rich diet, stick with whole foods, fruits, vegetables, nuts, seeds, and grain. Avoid animal protein and dairy. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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Can you tell me about immunobiology - complement cascade?

Can you tell me about immunobiology - complement cascade?

Textbook: This is a subject which should be studied with a textbook. Briefly complement is a system whereby the body kills off offenders. However there are check-and-balance system to make sure that it does not go too far leading to unwanted tissue damages. ...Read more

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Anyone have lupus or know any information on C4 complement?

Anyone have lupus or know any information on C4 complement?

Low levels = bad: Rheumatologists measure C4 and C3 levels in lupus because low levels are seen in active disease. ...Read more

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My blood work came back with elevated ssa auto antibodies, high jo-1 autoantibodies and my complement total was high, what does this indicate?

My blood work came back with elevated ssa auto antibodies, high jo-1 autoantibodies and my complement total was high, what does this indicate?

Need more info: You need tell why the tests were ordered in the first place. What symptoms do you have? Test results cannot be accurately interpreted in a vacuum as ssa and jo-1 antibodies can be positive in normal on occasion. In general elevated complements mean nothing, jo-1 can be positive in anti-synthetase syndrome (look it up) and ssa positive in sle or sjogren's. ...Read more

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Painful bumps on both shins. Now one swollen ankle. Had a strange rash a few weeks ago. Dr. Is at a loss. Had a blood panel done. Not abnormal. Help!

Painful bumps on both shins. Now one swollen ankle. Had a strange rash a few weeks ago. Dr. Is at a loss. Had a blood panel done. Not abnormal. Help!

Erythema nodosum????: You need to see a rheumatologist. Looka like- erythema nodosum (painful bumps), rash, arthritis involving ankle --- several infectious and non infectious diseases can do this. ...Read more

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What does a high complement 3 (c3) blood test result mean?

What does a high complement 3 (c3) blood test result mean?

What are other: Findings. C3 is an acute phase reactant and will increase in many situations associated with inflammation. It would be usual to see isolated increase in c3. ...Read more

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What does it mean by complement activation?

What does it mean by complement activation?

Complement: Is a series of immune proteins that are usually cause a "chain reaction" of events that lead to inflammation and when activated by infection, hormonal changes, etc., it will cause this chain reaction to start aka complement activation. ...Read more

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What does high immunoglobulin IG m and complement mean?

What does high immunoglobulin IG m and complement mean?

Depends: The "normal ranges" for all lab tests include 95% of the "normal" population; thus, 2.5% of people are above the upper limit, and 2.5% are below the lower limit. There's nothing to worry about if your values are a little bit above the normal range, but a very elevated IgM could be a sign of a problem. You need to check with the physician who ordered the tests to interpret your results. ...Read more

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What do low complement levels indicate is going on?

What do low complement levels indicate is going on?

Some things: To consider:
1) autoimmunity (particularly sle)
2) immunodeficiency
3) blood dyscrasia or cancer. ...Read more

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Complement C4 is. 12 (normal is. 14 -.54) is it worth getting repeated.

Complement C4 is. 12 (normal is. 14 -.54) is it worth getting repeated.

Depends: Complement C4 being low could indicate an issue with activation of the complement system such as after infection. It could also be related to liver disease, genetic deficiency of complement, vasculitis, lupus, or even could possibly just be a low-normal value for you. So I would repeat testing only if you have other medical concerns that are currently being evaluated. ...Read more

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What foods complement each other well nutritionally?

Whole foods: If you want the best nutritionally rich diet, stick with whole foods, fruits, vegetables, nuts, seeds, and grain. Avoid animal protein and dairy. ...Read more

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What is the definition or description of: complement?

Complement System: The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by natural "tick-over" of C3. ...Read more

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How is complement involved in immune responses?

Complement: The complement system helps antibodies and phagocytic cells clear pathogens. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. Generally synthesized by the liver. Stimulated by one of several triggers....Etc. ...Read more

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What does high hemolytic complement mean?

Likely response to: Inflammation. Complement is one of the acute phase reactants that increase in response to inflammation in the body. All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. ...Read more

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What would having low complement levels indicate?

What would having low complement levels indicate?

Low complement: Low levels of complement are seen in persons with complement deficiency who are prone to recurrent infections as well as in certain autoimmune conditions, inherited angioedema conditions, and hives associated with vasculitis (inflammed blood vessels). These can all be serious. Collection of blood to measure complement is tricky and needs to be done right or low level could occur. ...Read more

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What do low complement levels indicate is going on?

Some things: To consider:
1) autoimmunity (particularly sle)
2) immunodeficiency
3) blood dyscrasia or cancer. ...Read more

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What does complement alternative pathway test show?

Mechanism for diseas: If you have a disease compatible with a complemented activated disorder, this test may be performed. It is an attempt to detect a mechanism for your disease condition. ...Read more

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What does high immunoglobulin IG m and complement mean?

Depends: The "normal ranges" for all lab tests include 95% of the "normal" population; thus, 2.5% of people are above the upper limit, and 2.5% are below the lower limit. There's nothing to worry about if your values are a little bit above the normal range, but a very elevated IgM could be a sign of a problem. You need to check with the physician who ordered the tests to interpret your results. ...Read more

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I have type 1 obesity. What is the best pill to complement my diet?

I have type 1 obesity. What is the best pill to complement my diet?

Weight loss diet: If you are on a weight loss diet, you may be at risk for vitamin deficiencies, especially if you are avoiding fruits, which you should, if you want to lose efficiently. A good multivitamin may be your best friend in this situation. I have my weight loss patients take multivitamins, calcium, potassium, and fish oil. They are on a very low carb, medically supervised diet and they lose quickly. ...Read more

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Can someone please explain what "complement" is in your immune system?

Can someone please explain what "complement" is in your immune system?

Immune swat team: Antibodies are like folks in line at the post office studying the wanted posters. Later they spot a felon (bacteria), grab 'em by the arm & summon the complement swat team. Complement is a group of proteins circulating in extracellular fluid. The team arrives on the scene, assembles in a specific sequence & then punches holes in the bacteria killing it. Antibodies identify; complement rubs 'em out. ...Read more

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Does the human body even use the complement system at all to fight-off viruses?

Does the human body even use the complement system at all to fight-off viruses?

Yes: If viral antigens or epitopes are expressed on the surface of the infected cell, then yes. They may "fix complement" leading to lysis. ...Read more

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I am complement deficient without an autoimmune disorder. What is making me sick?

I am complement deficient without an autoimmune disorder. What is making me sick?

See rheumatologist: Something is eating up your complement and you may need a very good rheumatologist to find why whether there is an autoimmune process going on since negative ANA and RF do not rule out all autoimmune processes. If no cause can be found by your local MD, consider going to an university center. ...Read more

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Why are some complement fragments called opsonins, anaphylatoxins or chemotactic factors?

Why are some complement fragments called opsonins, anaphylatoxins or chemotactic factors?

Related to function: Opsonins bind microbes, particles and cell fragments flagging them for uptake/engulfment by macrophages or neutrophils. Anaphylatoxins, when released, bind to their receptors on macrophages and mast cells to activate the cells. Subsequently, the activated cells release mediators (eg histamine) involved in anaphylaxis and/or inflammation. Chemotactic factors guide WBCs to site of inflammation ...Read more

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What might a slightly elevated total hemolytic complement mean? (ref. Range 52-128, mine-131). Any need for concern?

No: Reference ranges are established so that 95% of healthy couch potatoes fall into them. If your physician is not concerned, I would not be either. ...Read more

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Can you tell me about immunobiology - complement cascade?

Textbook: This is a subject which should be studied with a textbook. Briefly complement is a system whereby the body kills off offenders. However there are check-and-balance system to make sure that it does not go too far leading to unwanted tissue damages. ...Read more

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What is complement c3?

What is complement c3?

Complement C3: Complement C3 is a blood test that measures the activity of a certain protein that is part of the complement system. The complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. This test is usually elevated in immune diseases or infections. ...Read more