Doctor insights on:
The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more
Textbook: This is a subject which should be studied with a textbook. Briefly complement is a system whereby the body kills off offenders. However there are check-and-balance system to make sure that it does not go too far leading to unwanted tissue damages. ...Read more
My blood work came back with elevated ssa auto antibodies, high jo-1 autoantibodies and my complement total was high, what does this indicate?
Need more info: You need tell why the tests were ordered in the first place. What symptoms do you have? Test results cannot be accurately interpreted in a vacuum as ssa and jo-1 antibodies can be positive in normal on occasion. In general elevated complements mean nothing, jo-1 can be positive in anti-synthetase syndrome (look it up) and ssa positive in sle or sjogren's. ...Read moreSee 1 more doctor answer
Is it necessary to measure complement C2 / C3 / C4 in a rheumatoid arthritis patient for severity or to see if treatment is working?
No: Measuring complements are a waste of money. ...Read more
Massage: Has soothing effects, helps relax body & mind. ...Read more
Painful bumps on both shins. Now one swollen ankle. Had a strange rash a few weeks ago. Dr. Is at a loss. Had a blood panel done. Not abnormal. Help!
What do you think it means when your complement level comes back high (176) but you test a "low" postive for lupus? This is for my 18 month old son.
Need more: A diagnosis of lupus requires way more testing than this. ...Read more
Depends: The "normal ranges" for all lab tests include 95% of the "normal" population; thus, 2.5% of people are above the upper limit, and 2.5% are below the lower limit. There's nothing to worry about if your values are a little bit above the normal range, but a very elevated IgM could be a sign of a problem. You need to check with the physician who ordered the tests to interpret your results. ...Read more
Depends: Complement C4 being low could indicate an issue with activation of the complement system such as after infection. It could also be related to liver disease, genetic deficiency of complement, vasculitis, lupus, or even could possibly just be a low-normal value for you. So I would repeat testing only if you have other medical concerns that are currently being evaluated. ...Read moreSee 1 more doctor answer
Complement System: The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by natural "tick-over" of C3. ...Read moreSee 1 more doctor answer
Complement: The complement system helps antibodies and phagocytic cells clear pathogens. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. Generally synthesized by the liver. Stimulated by one of several triggers....Etc. ...Read more
Low complement: Low levels of complement are seen in persons with complement deficiency who are prone to recurrent infections as well as in certain autoimmune conditions, inherited angioedema conditions, and hives associated with vasculitis (inflammed blood vessels). These can all be serious. Collection of blood to measure complement is tricky and needs to be done right or low level could occur. ...Read more
Mechanism for diseas: If you have a disease compatible with a complemented activated disorder, this test may be performed. It is an attempt to detect a mechanism for your disease condition. ...Read more