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Doctor insights on: Complement Component 3 C3

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I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

More than one issue: You did not state your age or gender and it is difficult to tie all the findings together without a physical examination. Vitamin d is the easiest to deal with, about 1/3 of the population has low vit d levels, and you can correct that with an over the counter supplement. Rest of the finding suggest and autoimmune process, but you need to consult a physician for a thorough evaluation. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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What does a high complement 3 (c3) blood test result mean?

What does a high complement 3 (c3) blood test result mean?

What are other: Findings. C3 is an acute phase reactant and will increase in many situations associated with inflammation. It would be usual to see isolated increase in c3. ...Read more

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Complement C3 & C4 tests done 3 times. C3 normal but twice C4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?

Complement C3 & C4 tests done 3 times. C3 normal but twice C4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?

Why the tests?: If the values were either borderline low or borderline normal, then one would call the value low normal. Whether it means anything or not would depends on whether you have a disease condition associated with complement consumption. A low C4 is usually found in patients with hereditary angioedema. ...Read more

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What is complement c3?

What is complement c3?

Complement C3: Complement c3 is a blood test that measures the activity of a certain protein that is part of the complement system. The complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. This test is usually elevated in immune diseases or infections. ...Read more

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My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

May be significant : Low Complement levels may be nonspecific markers for autoimmune disorders. Other symptoms and clinical findings are needed to be able to adequately answer your question. ...Read more

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What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?

Probably nothing: Decreased complement levels are seen in patients with active lupus. However, very minor abnormalities occur frequently, even in perfectly healthy individuals. These lab values must be viewed in the context of other lab studies and the clinical picture. Ask the physician who ordered the complement studies for his/her opinion as to the clinical relevance of this isolated lab abnormality. ...Read more

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Labcorp says that a serum complement C3 level of 89 mg/dl is low for an adult. Does this sound right?

Labcorp says that a serum complement C3 level of 89 mg/dl is low for an adult.  Does this sound right?

Maybe, maybe not: Complement levels are only relevant in the clinical setting. Though 89 may be borderline low, it may be irrelevant as the "normal" range is an approximation. On the other hand, if the complement level is steadily falling from one test to the next in a patient with known systemic lupus, it may be relevant. Remember that lupus cannot be diagnosed by complement levels or a positive ANA alone. ...Read more

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Ana 1:1280 nucleolar and complement C3 high. What does this mean?

Ana 1:1280 nucleolar and complement C3 high. What does this mean?

Maybe nothing: High complement is not a problem. The problem is more why do you have a + ana. The nucleolar pattern needs to be interpreted with the clinical picture. Your evaluation will help clarify this. It may be germane to a helpth problem but i often see this wihtout an issue. This depends on the qulaity of the lab and what your clincial issues are. ...Read more

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What does ANA 1:1280 nucleolar and complement C3 high at 166 mean?

What does ANA 1:1280 nucleolar and complement C3 high at 166 mean?

High C3 - nothing: High c3 means nothing. ANA with nucleolar pattern could be related to scleroderma, but rheumatologic evaluation should clarify. ...Read more

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I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?

I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?

Not simple.: No association between still's & these complement deficiencies. C2 and c4 partial and complete defifiencies are not rare, affecting 1/200 people each. People with c2 and c4 deficiencies are more prone to diseases in the lupus family.C3 deficiencies are exceedingly rare and pose grave immune problems. The problem with low c2, c4, and c3 may reflect consumption of complement by vasculitis. Fms not! ...Read more

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