Doctor insights on:
Complement Component 3 C3
I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?
More than one issue: You did not state your age or gender and it is difficult to tie all the findings together without a physical examination. Vitamin d is the easiest to deal with, about 1/3 of the population has low vit d levels, and you can correct that with an over the counter supplement. Rest of the finding suggest and autoimmune process, but you need to consult a physician for a thorough evaluation. ...Read more
The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more
Complement C3 & C4 tests done 3 times. C3 normal but twice C4 was borderline normal or borderline low, 3rd time it was well within range. deficiency?
Why the tests?: If the values were either borderline low or borderline normal, then one would call the value low normal. Whether it means anything or not would depends on whether you have a disease condition associated with complement consumption. A low C4 is usually found in patients with hereditary angioedema. ...Read more
Complement C3 and C4 tests done 3 times due to lupus symptoms. C3 always normal but C4 borderline low twice, now normal. is this a deficiency?
Disease activity: I assume that the diagnosis of sLE has been confirmed. The concentration of C4 is much lower than C3. As C4 is ow normal, there is no deficiency. When sLE is active, C4 concentration may decrease because of it being used up by immune complexes in the blood. When disease activity lessens, less C4 is being used. ...Read more
Complement C3: Complement c3 is a blood test that measures the activity of a certain protein that is part of the complement system. The complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. This test is usually elevated in immune diseases or infections. ...Read more
My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?
What does it mean if my complement C3 serum was 4 points low on a scale of 90-180 and my C4 was normal? Could there be something wrong?
Probably nothing: Decreased complement levels are seen in patients with active lupus. However, very minor abnormalities occur frequently, even in perfectly healthy individuals. These lab values must be viewed in the context of other lab studies and the clinical picture. Ask the physician who ordered the complement studies for his/her opinion as to the clinical relevance of this isolated lab abnormality. ...Read moreSee 1 more doctor answer
Labcorp says that a serum complement C3 level of 89 mg/dl is low for an adult. Does this sound right?
Maybe, maybe not: Complement levels are only relevant in the clinical setting. Though 89 may be borderline low, it may be irrelevant as the "normal" range is an approximation. On the other hand, if the complement level is steadily falling from one test to the next in a patient with known systemic lupus, it may be relevant. Remember that lupus cannot be diagnosed by complement levels or a positive ANA alone. ...Read more
I have complement C3 n C4 deficient, ivr beem diagnosed with adult stills d. N fibro? Is deficiency in those to really rare?
Not simple.: No association between still's & these complement deficiencies. C2 and c4 partial and complete defifiencies are not rare, affecting 1/200 people each. People with c2 and c4 deficiencies are more prone to diseases in the lupus family.C3 deficiencies are exceedingly rare and pose grave immune problems. The problem with low c2, c4, and c3 may reflect consumption of complement by vasculitis. Fms not! ...Read moreSee 1 more doctor answer
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