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Doctor insights on: Complement Activation Panel

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Does complement affect IgG and IgM reactions with antigens?

Does complement affect IgG and IgM reactions with antigens?

Complement: Complement is a serum protein that works with IgM and some igg subtypes to destroy foreign invaders. Persons with complement deficiency can have an increased frequency of infections. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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What does it mean by complement activation?

What does it mean by complement activation?

Complement : Is a series of immune proteins that are usually cause a "chain reaction" of events that lead to inflammation and when activated by infection, hormonal changes, etc., it will cause this chain reaction to start aka complement activation. ...Read more

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Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Increased aldolase,  complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Complicated: When i was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Normal C-RP, Sed Rate, CBC, CMP, Rheumatoid fac., C3/C4 Complement and Cyclic Citrul peptide. ANA was negative. Does this rule out any auto-immune?

Normal C-RP, Sed Rate, CBC, CMP, Rheumatoid fac., C3/C4 Complement and Cyclic Citrul peptide. ANA was negative. Does this rule out any auto-immune?

Not necessarily: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Lab test do not equate to disease or the lack of it. It is good that all the test results are negative. It reduces your risk of an auto-immune disease to very very low, but does not exclude it 100%. ...Read more

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1/80 + ana, dual pattern, speckled, centro mere. High aca centromere. High histone ab, igg. See sxs list. Recommendations? Other blood tests -.

1/80 + ana,  dual pattern,  speckled,  centro mere.  High aca centromere.  High histone ab,  igg. See sxs list.  Recommendations? Other blood tests -.

Results meaningless: That's right, lab results are meaningless without a history of symptoms, past medical history, family history of related illnesses, previous laboratory tests & your response to medication so far. Without this other information one can only guess at a way to help you. You should be under the care of an experienced rheumatologist. Your primary care provider of local medical society can recommend one. ...Read more

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Muscle Biopsy Results Meaning? rare chronic inflammatory cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

Muscle Biopsy Results Meaning? rare chronic inflammatory
cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

All lab test need ..: With data we need clinical context. That is why you are having trouble. There is not enough information to provide an interpretation. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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Describe polyclonal and monoclonal antibody production?

Describe polyclonal and monoclonal antibody production?

Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more

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Lupus panel negative. Sed rate 30 should b under 20. Ana positive w/ spec pattern. Serum protein electrophoresis test normal. Cbc ok. Metabolic ok.?

Lupus panel negative. Sed rate 30 should b under 20. Ana positive w/ spec pattern. Serum protein electrophoresis test normal. Cbc  ok. Metabolic ok.?

Any joint pain?: Positive ANA and elevated sed rate. If you have joint pains it would be advisable to follow up with a rheumatologist. You have some kind of inflammatory process going on. Both test are very nonspecific and further work-up is needed. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What does high anti EBV VCA IgA means?

What does high anti EBV VCA IgA means?

Not much: It just means that you have been exposed (or infected) to EBV at an indeterminate time. ...Read more

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Antinuclear body titer value: anti nuclear anti body pattern: speckled / titer: 80 (0 to 200) what means 80 (0 to 200) is a positive test?

Antinuclear body titer value: anti nuclear anti body pattern: speckled / titer: 80 (0 to 200) what means 80 (0 to 200) is a positive test?

Depends...: ANA titers of 1:80 are indeterminant. 1:40 is considered negative, 1:160 is positive. It depends on what symptoms you are having and why the test was ordered in the first place. http://www.medicinenet.com/antinuclear_antibody/page3.htm https://en.Wikipedia.Org/wiki/anti-nuclear_antibody. ...Read more

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Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?

Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?

Asking what?: If your are requesting a diagnosis online, this is not the appropriate venue. Though the flow cytometry results are not totally normal, your results should be reviewed with the physician who ordered it. This format does not give us the ability to determine if your clinical presentation and lab results are consistent with a specific diagnosis. ...Read more