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Doctor insights on: Compazine Vs Zofran For Nausea

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Compazine, (prochlorperazine) promethozine and Zofran are all meds IV taken for my cronic severe nausea. What else is there to help? Please

Compazine, (prochlorperazine) promethozine and Zofran are all meds IV taken for my cronic severe nausea. What else is there to help? Please

Why nausea?: At age 19, you need to get to the bottom of why you are chronically nauseated. This is not normal. Nausea is a symptom of disease/disorder. Those meds are fine if you have a stomach flu and need to get over the hump for a week, but chronic use of them screams for getting further evaluation to figure out why you have this symptom. You need to see a GI doctor and work with them to find cause! ...Read more

Dr. James Lin
52 Doctors shared insights

Prochlorperazine (Definition)

Prochlorperazine is an inotrope which is a kind of heart ...Read more


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Which causes more drowsiness - compazine (prochlorperazine) or zofran?

Which causes more drowsiness - compazine (prochlorperazine) or zofran?

Compazine (prochlorperazine) does...: Ondansetron (zofran), a powerful anti-nausea drug, is a serotonin 5-ht3 receptor antagonist. It blocks these "receptors" linked to the crtz. The "vomiting center" located in our brains. Compared to compazine, (prochlorperazine) a piperazine phenothiazine linked to other brain receptors (d2), it causes very little sedation. Both are used to decrease nausea and vomiting after surgery. ...Read more

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I have lupus and am now taking tacrolimus but it makes me nauseated; I am allergic to zofran. Ideas? Compazine and reglan (metoclopramide) not strong enough.

I have lupus and am now taking tacrolimus but it makes me nauseated; I am allergic to zofran. Ideas? Compazine and reglan (metoclopramide) not strong enough.

Promethazine: Promethazine is used to prevent and treat nausea and vomiting. It is a great antiemetic and may be a good replacement for zofran (ondansetron).
Rec.: talk to your treating physician before making any changes.
Hope it helps. ...Read more

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Does Zofran (ondansetron) help relieve icky nausea caused by acid reflux?

Does Zofran (ondansetron) help relieve icky nausea caused by acid reflux?

No Biggy: Why not just take care of the acid reflux? There are many medications for it, and dietary modification, even Tums. Yes, Zofran (ondansetron) (ondansetron) helps nausea but it will make you drowsy (maybe that's what you need?), and yes, you could take a Zofran (ondansetron) if the acid reflux makes you nauseated. No biggy. But it's always better to attack the cause-that will then take care of the symptoms. And if not you'll need to see your doc ...Read more

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Can I take zofran with my tramadol to help with the nausea that the tramadol gives me?

Can I take zofran with my tramadol to help with the nausea that the tramadol gives me?

Well you can: But why are you taking a medication that gives you these effects? Return to doctor and get a different medication for pain ...Read more

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Is there anything to relieve nausea from flagyl? Zofran (ondansetron) doesn't seem to be helping.

Is there anything to relieve nausea from flagyl? Zofran (ondansetron) doesn't seem to be helping.

Nausea from meds: Controlling nausea can sometimes be a challenge. This side effect is very well known from flagyl. Upping the dose of the zofran may help, or your doc can try a different antiemetic such as reglan (metoclopramide) or compazine (prochlorperazine). My personal favorite is ginger-- usually I will eat 2 slices of the crystallized stuff or make a ginger tea by boiling a chunk of root for 10 min then adding honey to taste ...Read more

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What can I take to ease the symptoms of flagyl? I already suffer from really bad nausea and am taking Zofran (ondansetron) 8 mg

Flagyl: Not sure what you are taking Flagyl for. Try taking it on a full stomach. If you still do not tolerate it, speak to your doctor who may be able to switch it to another medication depending on your diagnosis. ...Read more

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Can I take Zofran for occasional nausea while taking the generic form of Lexapro (escitalopram) (on 5mg now will end up at 10mg)?

Can I take Zofran for occasional nausea while taking the generic form of Lexapro (escitalopram) (on 5mg now will end up at 10mg)?

Yes: No interaction of significance at this dose but tell your doctor you are having nausea. (Look for cause of this symptom) Lexapro (escitalopram) can occasionally cause nausea. ...Read more

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Had persistent nausea. Had gallbladder out. 1 week post-op, still loss off appetite and nausea. Zofran (ondansetron) doesn't always help.

Watchful waiting: Maybe the nausea was never related to the gallbladder or it is related to the operation itself. For now, just need to wait. If it persists for another 3-6 months, see a GI doctor for a consult. Could be sphincter of oddi dysfunction, gastroparesis, or even gerd. Hope it gets better! ...Read more

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Taking Zofran (ondansetron) odt for nausea. Doc said I could double 4mg tablets. I took 2 tablets 4 hours ago is it okay take another dose?

Maybe: In general, zofran (ondansetron) is made for short-term usage, and if it has not gotten your symptoms under control yet, adding more is unlikely to help. If, however, it was helping and has worn off, taking one additional tablet would be okay. Again, in the short-term.
Keep in mind zofran (ondansetron) is an opiate relative, which means if you have a drug or alcohol history or a family history, it is not your best choice. ...Read more

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Started feeling nausea like I was gonna a vomit out of nowhere. Took 8mg Zofran 20min ago how long till it works? Haven't vomited yet but nauseous. HELP

Started feeling nausea like I was gonna a vomit out of nowhere. Took 8mg Zofran 20min ago how long till it works? Haven't vomited yet but nauseous. HELP

Depends on why: Nausea and vomiting in a 20yo female can result from something as simple as an emotional reaction to very serious but rare emergency conditions. If it comes with diarrhea its usually food poisoning or a virus. Without diarrhea could be pregnancy, a UTI*, or other pelvic problem. If there is abdominal or pelvic pain or fever, go to the ER. If your body has good reason to vomit, Zofran won't stop it. ...Read more

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On 1.2mg victoza, (liraglutide) some days I have nausea and some days I don't, took Zofran 8mg didn't work, took two and worked great, what should I do for nausea?

Bedtime: Take it at night before bed to see if that would help. It's a long acting glp-1so doesn't need to do it with foods. If you still have nausea in the am, consider a different drug instead. There are many options available. ...Read more

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What're the effects of long term Zofran (ondansetron) use for treating chronic nausea caused by anxiety? Been taking abt 3, 4mg pills per week for 1.5 years already

What're the effects of long term Zofran (ondansetron) use for treating chronic nausea caused by anxiety? Been taking abt 3, 4mg pills per week for 1.5 years already

Hi. I'm not aware of: Significant problems reducing and then eliminating Zofran (ondansetron) from your regemen. I would suggest to have an alternative plan to treat the nausea, when it comes. Start tapering by reducing your daily dose in half. Let us know how it goes. Shabbat Shalom. ...Read more

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Zofran (ondansetron) hasn't been working. Can 1000mg ginger capsule help with nausea due to anxiety? Recently tried it & possibly helped. Psychological or physical?

Zofran (ondansetron) hasn't been working. Can 1000mg ginger capsule help with nausea due to anxiety? Recently tried it & possibly helped. Psychological or physical?

Effect of ginger: Ginger root helps seasickness and motion sickness, and does help nausea caused by many etiologies. So, your 1000 mg ginger root capsule does in fact work fairly well. In my experience, seems equivalent to many prescriptions, and OTC meclizine and dramamine (dimenhydrinate). ...Read more

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I take lithium once a day in the morning. Is it safe to take zofran (ondansetron) for nausea?

Bipolar Disorder: I feel empathy for you.
Per your information, you are taking Clonazepam, Lisinopril, Bronchodilater and had electric shock therapy.
Taking Lithium in divided dose-2-3 times/day with meal can avoid nausea.
Zofran can have many side effects. Benadryl, Dramamine and Phenergan (promethazine) can be helpful. Follow with Psychiatrist for diagnosis, benefits and side effects of medications, dose; and Therapy. ...Read more

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If I usually take 8mg Zofran for anxiety induced nausea, then when I actually get sick do I need to take more since my body is already used to 8mg?

If I usually take 8mg Zofran for anxiety induced nausea, then when I actually get sick do I need to take more since my body is already used to 8mg?

TREAT THE ANXIETY: There should not be a tolerance to Zofran and it really depends on the frequency that you are feeling anxious. That is what should really be addressed. Your anxiety disorder ...Read more

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Does zofran (ondansetron) stop nausea from panic attacks?

It can: Yes, the medication can short-circuit nausea and vomiting due to panic attacks. Better solution might be to reduce the panic attacks themselves either entirely or by intensity and frequency. Then, Zofran (ondansetron) becomes a non-issue. ...Read more

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Will Zofran (ondansetron) or other nausea medication help with panic attacks?

Will Zofran (ondansetron) or other nausea medication help with panic attacks?

No: Panic can cause nausea and zofran (ondansetron) would help with that symptom, but will not help with the panic attacks themselves. ...Read more

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Can I take zofran (ondansetron) for nausea if I take 10mg prozac once a day? Are there any interactions?

Can I take zofran (ondansetron) for nausea if I take 10mg prozac once a day? Are there any interactions?

Probably ok: Sometimes there is an interaction, but generally, these can be safely used together.

Zofran can cause sleepiness, this is the primary side effect to be aware of. ...Read more

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I.V. vs I.M. injection of Zofran (ondansetron) for nausea caused by norovirus: which one is better and why?

I.V. vs I.M. injection of Zofran (ondansetron) for nausea caused by norovirus: which one is better and why?

IV is faster onset: IV (intravenous) vs. IM (intramuscular) are different ways this drug can be administered. Based on pharmacologic references the effects of Zofran (ondansetron) typically peak at end of IV infusion and typically peak around 30 mins for IM injection. Therefore onset of action of IV is faster however you need a IV line in place to administer therefore typically done in hospital or infusion center. ...Read more

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Will compazine (prochlorperazine) help my nausea but. Also help me go to sleep. My adderal is still working even after 6hrs and I just want a good night sleep?

Will compazine (prochlorperazine) help my nausea but. Also help me go to sleep. My adderal is still working even after 6hrs and I just want a good night sleep?

Adderall (dextroamphetamine and racemic amphetamine) insomnia: Yes, it can cause drowsiness as a serendipitous side effect and help nausea. Need to take adderall earlier, it seems. Be careful with compazine (prochlorperazine). It is supposed to be able to cause movement disorders, although I personally have never seen it happen. I prefer ondansetron (Zofran) for nausea or Tigan for that reason. ...Read more

Compazine (Definition)

Prochlorperazine is an inotrope which is a kind of heart ...Read more


Dr. James Henning
430 Doctors shared insights

Ondansetron (Definition)

Ondansetron is a nausea and vomiting agent which is a ...Read more