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Doctor insights on: Compazine And Zofran

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Which causes more drowsiness - compazine (prochlorperazine) or zofran?

Which causes more drowsiness - compazine (prochlorperazine) or zofran?

Compazine (prochlorperazine) does...: Ondansetron (zofran), a powerful anti-nausea drug, is a serotonin 5-ht3 receptor antagonist. It blocks these "receptors" linked to the crtz. The "vomiting center" located in our brains. Compared to compazine, (prochlorperazine) a piperazine phenothiazine linked to other brain receptors (d2), it causes very little sedation. Both are used to decrease nausea and vomiting after surgery. ...Read more

Dr. Ana Adelstein
52 Doctors shared insights

Prochlorperazine (Definition)

Prochlorperazine is an inotrope which is a kind of heart ...Read more


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Compazine, (prochlorperazine) promethozine and Zofran are all meds IV taken for my cronic severe nausea. What else is there to help? Please

Compazine, (prochlorperazine) promethozine and Zofran are all meds IV taken for my cronic severe nausea. What else is there to help? Please

Why nausea?: At age 19, you need to get to the bottom of why you are chronically nauseated. This is not normal. Nausea is a symptom of disease/disorder. Those meds are fine if you have a stomach flu and need to get over the hump for a week, but chronic use of them screams for getting further evaluation to figure out why you have this symptom. You need to see a GI doctor and work with them to find cause! ...Read more

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I have lupus and am now taking tacrolimus but it makes me nauseated; I am allergic to zofran. Ideas? Compazine and reglan (metoclopramide) not strong enough.

I have lupus and am now taking tacrolimus but it makes me nauseated; I am allergic to zofran. Ideas? Compazine and reglan (metoclopramide) not strong enough.

Promethazine: Promethazine is used to prevent and treat nausea and vomiting. It is a great antiemetic and may be a good replacement for zofran (ondansetron).
Rec.: talk to your treating physician before making any changes.
Hope it helps. ...Read more

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What exactly is Zofran (ondansetron) used for?

What exactly is Zofran (ondansetron) used for?

Nausea/Vomiting: Zofran (ondansetron) is typically used for nausea/vomiting prevention and also chemotherapy-related nausea. I've seen it used for other nausea prevention related purposes too. ...Read more

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Is Zofran (ondansetron) safe while pregnant?

Zofran (ondansetron) in pregnancy: Zofran (ondansetron) may be used to treat nausea and vomiting associated with pregnancy. It is listed in category b for pregnancy which means that animal studies have shown no risk to fetus but human studies didn't confirm or are not available. Fetal harm is possible but unlikely. ...Read more

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Does compazine (prochlorperazine) help anxiety?

Does compazine (prochlorperazine) help anxiety?

Compazine (prochlorperazine): Nope. This drug is used to help alleviate nausea. ...Read more

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Is Zofran (ondansetron) used for memory problems?

Anti-emetic: This is a potent anti-nausea drug used for patients when they undergo chemotherapy, or for patients to pre-empt nausea and vomiting following general anesthesia. ...Read more

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Can compazine be given with reglan (metoclopramide)?

Yes: The patient may get a bit sleepy but you can. We did that very often in anesthesia when person was refractory to Compazine then we added Reglan (metoclopramide) iv. ...Read more

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Are prochlorperazine and procyclidine the same thing?

Procyclidine/Prochlo: Prochlorperazine (Compazine) is for treating nausea/vomiting. Procyclidine (Kemadrin) is for treating side-effects of Antipsychotics. ...Read more

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Can I take Zofran (ondansetron) and pepto bismol together?

Can I take Zofran (ondansetron) and pepto bismol together?

Should be fine: The zofran (ondansetron) is for nausea and vomiting and you should wait at least 1/2 hour after using it in the disolvable form before using the pepto ...Read more

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Does the drug Zofran (ondansetron) have withdrawal symptoms?

NO: Zofran (ondansetron) is an antiemetic. Whatever sedation you may experience that you may think is an "addiction problem" is not. Withdrawl occurs after long periods of drugs with such addictive properties which are abruptly stopped. ...Read more

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Can I give my son motrin while he is on zofran (ondansetron)?

Can I give my son motrin while he is on zofran (ondansetron)?

Motrin for child: I recommend asking your son's pediatrician first, especially as I am not sure what his age is, what other medications he takes, and what his symptoms are to need motrin. His pediatrician is familiar with his medical records & history and can be your best advisor. Good luck. ...Read more

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Can you take atorvastatin 40mg and prochlorperazine 5mg together?

Can you take atorvastatin 40mg and prochlorperazine 5mg together?

Yes: According to Epocrates my subscription drug app. There is no interaction between these 2 drugs. However
I added your other listed drugs. There are interactions btw Norco and Tylenol; Compazine (prochlorperazine) and Norco. Contact your pharmacist and Doctor to discuss the risks benefits of taking all of these drugs together at once. ...Read more

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Is there a stronger medicine than Zofran (ondansetron) for nausea?

No: The four common medications (zofran, compazine, phenergan, (promethazine) and reglan) used for nausea are all effective. Neither is stronger or better than another but some people respond more favorably to specific ones. ...Read more

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I was wondering are compazine and reglan (metoclopramide) related?

No: Compazine is a phenothiazine-antihistamine. Reglan (metoclopramide) is a dopamine inhibitor with a host of potential serious side effects. ...Read more

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What happens if you take percocet with compazine (prochlorperazine)?

Sedation and more: These medications should only be taken together if specifically directed by your physician. The combination will be more sedating and constipating. There are reports of low blood pressure.
Only take these if your physician directed you to do so and follow up with her/him if you have any issues. ...Read more

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Will you have withdrawl from Zofran after taking it everyday for a month?

No: You will not have a physical dependence syndrome (withdrawal) from Zofran, but if the underlying problem is still there, symptoms may get worse for lack of treatment. Talk with your doctor for the best course of action. ...Read more

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How long after taking 10mg of metoprolol can I take 10mg of prochlorperazine?

How long after taking 10mg of metoprolol can I take 10mg of prochlorperazine?

Drug interaction: The two drugs that you mention are noted to have a drug interaction in that they might cause your blood pressure to drop even further. All drug interactions are not necessarily bad and they will not necessarily happen in you. It has been noted. ...Read more

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What can I do to relieve nausea? Zofran (ondansetron) hasn't helped this time.

What can I do to relieve nausea? Zofran (ondansetron) hasn't helped this time.

HopefullyFindACause: First, double the dose of Zofran (ondansetron). And if you can, chew it up and let it dissolve and get absorbed through your mouth. If that doesn't work you might consider seeing a doctor to make sure nothing serious is going on, especially if you have fever or a headache. Other than Dramamine, other effective medications for nausea require a prescription unless you want to try herbs or homeopathic medications. ...Read more

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In the state of NC, can Zofran (ondansetron) come in the form of a suppository?

Not available: Zofran or ondansetron is available as oral disintegrating tablets (ODT) or oral soluble films, but not as a suppository. ...Read more

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Does emend always have to be taken with zofran (ondansetron)? Or can it be taken alone?

Yes: It has to be taken with zofran (ondansetron) or a drug that is
in the same class as Zofran (ondansetron). They have actually now approved a pill that has both in it ...Read more

Compazine (Definition)

Prochlorperazine is an inotrope which is a kind of heart ...Read more


Dr. James Henning
425 Doctors shared insights

Ondansetron (Definition)

Ondansetron is a nausea and vomiting agent which is a ...Read more