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Doctor insights on: Coming Off Lupron

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What does lupron (leuprolide) do?

What does lupron (leuprolide) do?

Hormone inhibitor: Lupron (aka leuprolide) inhibits the production of testosterone and estrogen from the testes and ovaries, respectively. It is used in the treatment of a number of things including endometriosis, prostate and breast cancer and inappropriately early puberty in kiddos, each of which is made worse by excessive testosterone or estrogen secretion. ...Read more

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Dr. Linda Callaghan
150 doctors shared insights

Leuprolide Acetate (Definition)

Leuprolide acetate is a GnRH stimulator which is a kind of women's ...Read more


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What are side affects of lupron (leuprolide)?

What are side affects of lupron (leuprolide)?

Menopausal effects: Lupron (leuprolide) injections are used for many reasons in gynecology, most commonly in the treatment of fibroids and endometriosis. Essentially, Lupron (leuprolide) shuts down ovarian function and leads to a menopausal state. Therefore, side effects include hot flashes, vaginal dryness, mood swings, decreased libido, and bone loss. ...Read more

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How long does one lupron (leuprolide) shot last?

How long does one lupron (leuprolide) shot last?

Depends: Leuprolide acetate is available in two long-acting formulations as Lupron (leuprolide) depot. It is available in a 1-month and a 3-month version. Microdose Lupron (leuprolide) as used for ivf is generally very short acting, but the pharmacology is too complex to explain here. ...Read more

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What was your experience with lupron (leuprolide)?

What was your experience with lupron (leuprolide)?

Depends/ indications: I agree with the prior answer in context, but want to weigh in on other uses. Studies show Lupron (leuprolide) in the depot form is effective at shrinking fibroid volume by about 1/3 in 3 months. This gives a proven statistically lower blood loss in women preparing for surgical myomectomy. Also Lupron (leuprolide) in the non-depot form is safe, effective and routinely used in stimulations for ivf. ...Read more

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Complcations with long use of lupron (leuprolide)?

Complcations with long use of lupron (leuprolide)?

Yes: Long term use of Lupron can weaken the bone. Anyone on long term Lupron should be on add back therapy to prevent bone loss as well as calcium and vitamin d. Long term Lupron can also predispose to heart disease and so estrogen add back should be considered to prevent this risk. ...Read more

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Are there symptoms associated with lupron (leuprolide) ?

Are there symptoms associated with lupron (leuprolide) ?

None serious.: There are no known serious side effects from the Lupron (leuprolide) trigger. Some mild side-effects might include: hot flashes, vaginal dryness, and headaches. ...Read more

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Can you tell me about taking lupron (leuprolide) shot in my 30's?

Can you tell me about taking lupron (leuprolide) shot in my 30's?

Endometriosis: Lupron is a powerful suppressor of estrogen activity (mediated through the hypothalamus and pituitary), and it is used to suppress symptoms of endometriosis. It has many side effects including hot flashes and bone loss.

Many doctors use this but I do not. It is my professional opinion (and profession) that women with endometriosis would benefit more from expert excision of their disease. ...Read more

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Why do we have to take lupron (leuprolide) and norethidrone together?

Why do we have to take lupron (leuprolide) and norethidrone together?

Add back therapy: Lupron (leuprolide) acts on the pituitary to shut down production of hormones such as estrogen. This can lead to side effects such as hot flashes and bone loss. Adding back some hormones, in this case progestin, can help ameliorate these symptoms. ...Read more

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What should happen when my last dose of lupron (leuprolide) wears off?

What should happen when my last dose of lupron (leuprolide) wears off?

After Lupron (leuprolide): A 3.75 lupron (leuprolide) depot dose well generally take a while to wear off. After 4 weeks, the dose should be gone and your would start growing a follicle for the next cycle, if you have regular cycles. Expect a subsequent period about 6-8 weeks after the last injection. The hot flashes usually subside about 4-6 weeks after the last injection. The more doses you have receive, the longer it may take. ...Read more

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How long does it take fo the effects of lupron (leuprolide) to wear off?

How long does it take fo the effects of lupron (leuprolide) to wear off?

Varies: There are three forms of lupron, (leuprolide) one is a subcutaneous injection daily which will wear off very quickly. The second type is a depot form which last for approximately 30 days in the body, and lastly there is a 90 day form. A woman will usually ovulate 2 to 4 weeks after the effects of the Lupron (leuprolide) has worn off. ...Read more

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My husband has been on lupron (leuprolide) x 3 years how long can he take this drug?

My husband has been on lupron (leuprolide) x 3 years how long can he take this drug?

No time limit: It really depends upon its benefit to your husband. Men with metastatic disease can have long term benefit. ...Read more

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Lupron (leuprolide) shot and side effects?

Lupron (leuprolide) shot and side effects?

Hot Flashes: By far, the most common side effect is hot flashes, because Lupron (leuprolide) causes a temporary menopause. Poor sleep resulting in emotional side effects or head ache are also common. A serious effect from long-term Lupron (leuprolide) is osteoporosis. Many of these side effects are reduced or eliminated with extra "add-back" hormones. Some women have no side effects at all. ...Read more

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What are the side effects of lupron (leuprolide)?

What are the side effects of lupron (leuprolide)?

Terrible: Lupron (leuprolide) causes reversible menopause. So as soon as the medicine takes effect the estrogen drops to zero same as complete menopause. Hot flashes, night sweats, moods, memory issues and joint pain etc. Many dr.S use this for endometriosis but endo is a surgically treated disease. Lupron (leuprolide) only temporarily diminishes symptoms but makes people miserable. Excisional surgery is needed via laparoscopy! ...Read more

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What are the effects of depot lupron (leuprolide)?

What are the effects  of depot lupron (leuprolide)?

Few: Low estrogen causes hot flashes, dry vagina, and osteoporosis (week bones). Local reaction at the injection site. Some of the effects of low estrogen can be minimized by estrogen add back therapy (taking very small amount of estrogen). ...Read more

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Can the side effects of lupron (leuprolide) be reversed?

Can the side effects of lupron (leuprolide) be reversed?

Yes: If you are currently on lupron, (leuprolide) there are commonly side effects such as hot flashes. These can easily be treated with supplemental hormones. The most commonly used hormone is progesterone. Many physicians will start with norethindrone, 5mg per day. Good luck! ...Read more

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Has anyone ever taken lupron (leuprolide) shots for adenomyosis?

Has anyone ever taken lupron (leuprolide) shots for adenomyosis?

Maybe: Lupron (leuprolide) is typically used to treat endometriosis and to shrink fibroids before surgery. It would likely temporarily relieve the symptoms of adenomyosis, but would not cure it. Hysterectomy is the most common treatment option if no more pregnancies are desired. ...Read more

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What are the medical uses of lupron (leuprolide) depot injections?

What are the medical uses of lupron (leuprolide) depot injections?

Endometriosis ...: Depo-lupron monthly or 3-month injections are used for women with endometriosis or chronic pelvic pain, men with prostate cancer, and children with puberty too young. It may be used to shrink uterine fibroids before surgery. Depo-lupron is used in fertility treatment to prevent ovulation in frozen embryo transfer cycles & egg donor recipients, and can be used before ivf in women with endometriosis. ...Read more

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Lupron (leuprolide) depot not helping. What are some alternatives?

Lupron (leuprolide) depot not helping. What are some alternatives?

Assume Pelvic Pain: ? Diagnosis endometriosis and pain. If Lupron (leuprolide) is not helping, the pain is either coming from very severe endo, or from another source. A common associated pain is from the inguinal region and is often associated with endo. Surgery to correct this relieves pain in more than 80%. There are other potential causes of pain that should be evaluated. Seek pelvic pain/endo specialist for more help. ...Read more

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How long do the side effects of lupron (leuprolide) typically last?

How long do the side effects of lupron (leuprolide) typically last?

1 or 3 months: Lupron (leuprolide) comes in 1 or 3 month doses (3.75 or 11.25 mg) and these injections usually cause menopause symptoms which i've seen as both mild or severe. It rarely continues beyond the treatment period & is a good way to pre-treat or reverse endometriosis or to shrink fibroid tumors prior to surgery. Discuss with your doc if your symptoms are severe or if you need estrogen to counter the severe effects. ...Read more

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Dr. AARATHI Cholkeri-Singh
160 doctors shared insights

Lupron (Definition)

Lupron is a GnRH stimulator which is a kind of women's ...Read more