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Doctor insights on: Coming Off Lupron

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What does lupron (leuprolide) do?

What does lupron (leuprolide) do?

Hormone inhibitor: Lupron (aka leuprolide) inhibits the production of testosterone and estrogen from the testes and ovaries, respectively. It is used in the treatment of a number of things including endometriosis, prostate and breast cancer and inappropriately early puberty in kiddos, each of which is made worse by excessive testosterone or estrogen secretion. ...Read more

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Dr. Scott Keith
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What are side affects of lupron (leuprolide)?

What are side affects of lupron (leuprolide)?

Menopausal effects: Lupron (leuprolide) injections are used for many reasons in gynecology, most commonly in the treatment of fibroids and endometriosis. Essentially, Lupron (leuprolide) shuts down ovarian function and leads to a menopausal state. Therefore, side effects include hot flashes, vaginal dryness, mood swings, decreased libido, and bone loss. ...Read more

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How long does one lupron (leuprolide) shot last?

How long does one lupron (leuprolide) shot last?

Depends: Leuprolide acetate is available in two long-acting formulations as Lupron (leuprolide) depot. It is available in a 1-month and a 3-month version. Microdose Lupron (leuprolide) as used for ivf is generally very short acting, but the pharmacology is too complex to explain here. ...Read more

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What was your experience with lupron (leuprolide)?

What was your experience with lupron (leuprolide)?

Depends/ indications: I agree with the prior answer in context, but want to weigh in on other uses. Studies show Lupron (leuprolide) in the depot form is effective at shrinking fibroid volume by about 1/3 in 3 months. This gives a proven statistically lower blood loss in women preparing for surgical myomectomy. Also Lupron (leuprolide) in the non-depot form is safe, effective and routinely used in stimulations for ivf. ...Read more

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Complcations with long use of lupron (leuprolide)?

Complcations with long use of lupron (leuprolide)?

Yes: Long term use of Lupron can weaken the bone. Anyone on long term Lupron should be on add back therapy to prevent bone loss as well as calcium and vitamin d. Long term Lupron can also predispose to heart disease and so estrogen add back should be considered to prevent this risk. ...Read more

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Are there symptoms associated with lupron (leuprolide) ?

Are there symptoms associated with lupron (leuprolide) ?

None serious.: There are no known serious side effects from the Lupron (leuprolide) trigger. Some mild side-effects might include: hot flashes, vaginal dryness, and headaches. ...Read more

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Why do we have to take lupron (leuprolide) and norethidrone together?

Why do we have to take lupron (leuprolide) and norethidrone together?

Add back therapy: Lupron (leuprolide) acts on the pituitary to shut down production of hormones such as estrogen. This can lead to side effects such as hot flashes and bone loss. Adding back some hormones, in this case progestin, can help ameliorate these symptoms. ...Read more

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What should happen when my last dose of lupron (leuprolide) wears off?

What should happen when my last dose of lupron (leuprolide) wears off?

After Lupron (leuprolide): A 3.75 lupron (leuprolide) depot dose well generally take a while to wear off. After 4 weeks, the dose should be gone and your would start growing a follicle for the next cycle, if you have regular cycles. Expect a subsequent period about 6-8 weeks after the last injection. The hot flashes usually subside about 4-6 weeks after the last injection. The more doses you have receive, the longer it may take. ...Read more

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How long does it take fo the effects of lupron (leuprolide) to wear off?

How long does it take fo the effects of lupron (leuprolide) to wear off?

Varies: There are three forms of lupron, (leuprolide) one is a subcutaneous injection daily which will wear off very quickly. The second type is a depot form which last for approximately 30 days in the body, and lastly there is a 90 day form. A woman will usually ovulate 2 to 4 weeks after the effects of the Lupron (leuprolide) has worn off. ...Read more

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My husband has been on lupron (leuprolide) x 3 years how long can he take this drug?

My husband has been on lupron (leuprolide) x 3 years how long can he take this drug?

No time limit: It really depends upon its benefit to your husband. Men with metastatic disease can have long term benefit. ...Read more

Dr. AARATHI Cholkeri-Singh
158 doctors shared insights

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