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Doctor insights on: Colonic Diseases Colorectal Cancer

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Colorectal cancer causes?

Colorectal cancer causes?

Heredity & diet: The cause is not known in most cases. In a small number the cause is clearly heredity, e.g., apc and hnpcc. In the garden variety colon cancer, a diet low in fiber and rich in fats may increase the risk of cancer. ...Read more

Dr. Herbert Hoover
238 doctors shared insights

Colorectal Cancer (Definition)

Colorectal cancer is cancer of the colon or rectum. The cells lining the colon or rectum become abnormal and grow uncontrollably. They start as polyps. Symptoms include blood in the stool, constipation, loss of appetite, and weight loss. This cancer can be prevented through early screening, if a polyp is detected during a colonoscopy and excised. Additionally, a high fiber diet with plenty of water and a ...Read more


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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more

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Colon cancer or colorectal cancer, what's the difference?

Colon cancer or colorectal cancer, what's the difference?

Location: Cancers that arise from the epithelium of the large intestine are similar in most ways whether they are in the colon or rectum. Discussions of "colon cancer" unspecified usually mean "colorectal" unless stated otherwise. Usage, including by me, is often sloppy. ...Read more

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Is colon cancer genetic?

Is colon cancer genetic?

Sometimes: Some colon cancers are related to specific genetic mutations but the majority are not. ...Read more

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Is rectal cancer hereditary?

Is rectal cancer hereditary?

Usually not : Most patients with rectal cancer have not inherited it. A small subset have genetic mutations that put them at risk. Probably around 5 % of rectal cancers are hereditary. ...Read more

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Can ulcerative pancolitis lead to colon cancer?

Can ulcerative pancolitis lead to colon cancer?

Yes: Ulcerative pancolitis, is a chronic disease that inflames the gastrointestinal (GI) system. Specifically, ulcerative colitis causes lesions in the colon. With the inflammation there is a higher risk for developing CRC. Two factors associated with cancer risk , is disease duration and extent of colon involvement . Early tumors develop denovo from carcinogens and utilize inflammation to progress ...Read more

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Are breast cancer and colon cancer linked?

Are breast cancer and colon cancer linked?

Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read more

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Is colon cancer curable?

Is colon cancer curable?

Yes: Yes. Many people are cured with colon cancer. If found early surgery alone may be curable. If more advanced (eg, lymph node involvement or metastatic = spread to areas outside of colon), then chemotherapy may be needed. While less likely, even a few % of people with metastatic colon ca may be cured. ...Read more

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Is bowel cancer hereditary?

Is bowel cancer hereditary?

Somehow yes: There is some genetic predisposition in families with hx. Of colorectal cancer. Diet also plays a rol ( low fiber diet increases cancer). Familiar poliposis increases chances of colon cancer. Colon polyps may degenerate in cancer. Small intestine cancers are rare and difficult to find. In general there are families affected by cancers and families affected by atherosclerosis but both together too. ...Read more

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How are anal cancer and colon cancer different?

See below: Anus is about 3-4 cm long from skin to the rectum which is the last part of colon. Colon is lined by columnar lining and cancer of this is very common and runs in families. Cancer arising in the anal skin which is squamous kind is more like skin cancer. Treatment is very different as is prognosis. ...Read more

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Is colon cancer preventable?

For the most part.: Early detection via colonosocpy, not ignoring symptoms such as bleeding, change in bowels, anemia, unintentional weight loss, and not assuming all rectal bleeding is from hemorrhoids are some ways to reduce your chances and maybe prevent colon cancer from developing. ...Read more

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Can colon cancer patients get a colon transplant?

Can colon cancer patients get  a colon transplant?

No, not needed: The good news is that you don't absolutely need your colon. For most colon cancers, the amount of colon that needs to be removed will not be missed. ...Read more

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What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

Both inherited: In fap presents as colonic polyps ( gardners syn will have other tumors ) , autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more

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How are colon cancer and intestinal cancer different?

How are colon cancer and intestinal cancer different?

Can be the same: The intestines are a group of structures including stomach, small intestine and large intestine (which is the colon). Cancers can form in any of these sites, but large intestine (colon) cancer is most common. So colon cancer is a type of intestinal cancer. ...Read more

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Large intestinal cancer. Is that colon cancer?

Large intestinal cancer. Is that colon cancer?

Yes: The large intestine and the colon are words to describe the same anatomic structure in the abdomen. ...Read more

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Is metastatic colon cancer curable?

Is metastatic colon cancer curable?

Possible: But less than 20% survive 5 years. Depends on where the metastases are and how numerous and size. Solitary liver mets without evidence elsewhere in the body can be cured with a liver resection. Diffuse mets to numerous body parts rarelyare curable. ...Read more

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What are colon or rectal cancers?

What are colon or rectal cancers?

Cancers of lower GI: These cancers start from the lining of the lower GI tract, and usually are found when patients have blood in their stools or when the patient has a colonoscopy. ...Read more

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Is bowel cancer genetic?

Is bowel cancer genetic?

Sometimes: Some colon cancers are related to inheritable genetic mutations but the majority are not. ...Read more

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Does colonoscopy prevent colon cancer?

Does colonoscopy prevent colon cancer?

Likely: Cancers start as polyps. Removing polyps decreases cancer risk, but no test guarantees finding every polyp. ...Read more

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Dr. Barry Rosen
4,404 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Dr. Daniel Saurborn
13 doctors shared insights

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more