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Doctor insights on: Colon Cancer Gene

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Grandfather had colon cancer at 87, uncle had noncancerous polyps at 48. Mother has no polyps. Likely a colon cancer gene?

Grandfather had colon cancer at 87, uncle had noncancerous polyps at 48. Mother has no polyps. Likely a colon cancer gene?

Likely Not: You have to have three or more family members with a confirmed diagnosis of colorectal cancer, one of whom should be a first degree (parent, child, sibling) relative. ...Read more

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Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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What gene do I need to get tested for the familial colon cancer?

What gene do I need to get tested for the familial colon cancer?

Need more info: Totally different genes predispose to colon cancer, including BRCA 1 and 2; Familial Adenomatous Polyposis develops so many polyps in the colon they may be too numerous to count--but this one is quite rare. The commonest is Hereditary Non-Polyposis Colon Cancer. You may be at increased risk if close family members have developed it. See http://www.hopkinscoloncancercenter.org/CMS/CMS_Page.aspx? ...Read more

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What is the benefit of knowing if I have the gene for colon cancer?

What is the benefit of knowing if I have the gene for colon cancer?

Planning : Not everyone wants to know about a risk for cancer. However knowing about colon cancer risk allows you to get a colonoscopy every year to check for cancer before it grows. Also it allows you to have a discussion with a surgeon about your options to remove the colon before it affects you. This can be life saving. There are different genes for colon cancer risk and they have different implications. ...Read more

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Are there any genes that will tell you what your course of colon cancer will be like?

Are there any genes that will tell you what your course of colon cancer will be like?

Not really: While there are certain genetic abnormalities that will help your doctor determine a course of treatment, as of yet there is no prognostic profile for colon cancer that is in general use. ...Read more

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Does the brca2 gene also cause colon cancer? Or just breast and ovarian?

Does the brca2 gene also cause colon cancer? Or just breast and ovarian?

BRCA for breast: Brca genetic mutations are for breast and ovarian cancers , for for colonic cancers apc gene, & familial non polyposis gene mutation are tested. 75% of colon cancers has no family history, best way to detect early is by regular doctor visits and colonoscopic examinations for early detection and cure. ...Read more

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Mom died of colon cancer, all 4 of dad's sis had breast cancer or precancer. 1 of the sis tested negative for cancer gene. Do I have elevated risk?

Yes, you do: First, i'm sorry to hear about your mom. That's so hard. And it's hard to worry about your own risk. You do have a higher risk of cancer, and it is probably not due to the breast/ovarian cancer gene (brca). Lynch syndrome is more likely. I can't tell you your exact risk because that depends on the age of your mom and your aunts when they were diagnosed. Tell every doctor this history from now on! ...Read more

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My mother was diagnosed with breast cancer at 54, grandmother had pancreatic cancer at 70 and great aunt had colon cancer at 65. No one else has cancer in my large family. Could I have the brca gene?

My mother was diagnosed with breast cancer at 54, grandmother had pancreatic cancer at 70 and great aunt had colon cancer at 65. No one else has cancer in my large family. Could I have the brca gene?

Very Low Risk: The risk of having a brca mutation can be estimated at: http://www.Myriadpro.Com/brca-risk-calculator/calc.Html. A woman with ashkenazi jewish heritage and this family history would have about an 8% chance of having a brca mutation. Without ashkenazi heritage the risk drops to 1.5%. The best way to know for sure would be to have your mother see a genetic counselor and consider having testing. ...Read more

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Is colon cancer genetic?

Is colon cancer genetic?

Sometimes: Some colon cancers are related to specific genetic mutations but the majority are not. ...Read more

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Is there a DNA test to check for colon cancer?

Is there a DNA test to check for colon cancer?

Yes, BUT.: There are commercial tests available. They are not more effective than other methods of screening ( fecal occult blood and colonoscopy) and are not as cost effective. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Dr. Eric Kaplan
923 doctors shared insights

Colon Cancer (Definition)

Final few yards of your intestine, between the terminal ileum (small bowell) and rectum. It squeezes water and solidifies waste to stool. It is subject to outpouching (divertics) polyps, and these can become cancers. The cells are abnormal, invade into the muscle and travel ...Read more